en Evaluation of Protective Effects of Nano-formulated Silymarin Against UV Radiation on Guinea Pig Skin گياهان دارویی Medicinal Plants پژوهشی Research <div dir="ltr" style="text-align: justify;"> <p style="text-align: justify;"><strong>Background:</strong> As increased outdoor activities of people, they are more exposed to UV radiation, which causes harmful effects on skin. Silymarin has protective potentials against DNA damage and non-melanoma skin cancers, and also it has anti-oxidant, anti-inflammatory, and immune regulation characteristics. Nano formulation of plant material showed to be more effective than common ones.</p> <p style="text-align: justify;"><strong>Objective:</strong> In present study, nano-formulated silymarin was used in a cream, and its effects were investigated against destructive effects of UV rays.</p> <p style="text-align: justify;"><strong>Methods:</strong> Silymarin standardized extract was prepared, nano formulated in cream base, and applied to skin of the animals. Four groups of animals (n=15) were examined Group 1 without any treatment (control), Group 2 Vaseline, Group 3 nano-formulated silymarin extract cream, and Group 4 silymarin-carnosine. UV was radiated on the shaved area of the four groups for 45 minutes with dose of 180 mJ/cm². Dermal scaling, skin irregularity, erythema, skin hyperpigmentation, and edema were evaluated in animals. Histopathological observation was done on the skin samples of the animals.</p> <p style="text-align: justify;"><strong>Results:</strong> silymarin nano-formulation was effective in decreasing both physical damages and histopathological injuries significantly.</p> <div style="text-align: justify;"><strong>Conclusion:</strong> from the observed results, it can be concluded that the cream containing nano-formulated silymarin can prevent UV radiation lesions better than pure silymarin.</div> </div> <p style="text-align: justify;"><strong>Background:</strong> As increased outdoor activities of people, they are more exposed to UV radiation, which causes harmful effects on skin. Silymarin has protective potentials against DNA damage and non-melanoma skin cancers, and also it has anti-oxidant, anti-inflammatory, and immune regulation characteristics. Nano formulation of plant material showed to be more effective than common ones.</p> <p style="text-align: justify;"><strong>Objective:</strong> In present study, nano-formulated silymarin was used in a cream, and its effects were investigated against destructive effects of UV rays.</p> <p style="text-align: justify;"><strong>Methods:</strong> Silymarin standardized extract was prepared, nano formulated in cream base, and applied to skin of the animals. Four groups of animals (n=15) were examined Group 1 without any treatment (control), Group 2 Vaseline, Group 3 nano-formulated silymarin extract cream, and Group 4 silymarin-carnosine. UV was radiated on the shaved area of the four groups for 45 minutes with dose of 180 mJ/cm². Dermal scaling, skin irregularity, erythema, skin hyperpigmentation, and edema were evaluated in animals. Histopathological observation was done on the skin samples of the animals.</p> <p style="text-align: justify;"><strong>Results:</strong> silymarin nano-formulation was effective in decreasing both physical damages and histopathological injuries significantly.</p> <div style="text-align: justify;"><strong>Conclusion:</strong> from the observed results, it can be concluded that the cream containing nano-formulated silymarin can prevent UV radiation lesions better than pure silymarin.</div> Nano-formulation, Silymarin, UV protection, Guinea Pig Nano-formulation, Silymarin, UV protection, Guinea Pig 86 96 http://jmp.ir/browse.php?a_code=A-10-201-3&slc_lang=en&sid=1 HR Ahmadi-Ashtiani حمیدرضا احمدی آشتیانی 100319475328460038131 100319475328460038131 No Department of Clinical Biochemistry, School of Medical Science, Tarbiat-e-Modarres University, Tehran, Iran & Biochemistry and Nutrition Department, Zanjan University of Medical Sciences, Zanjan Department of Clinical Biochemistry, School of Medical Science, Tarbiat-e-Modarres University, Tehran, Iran & Biochemistry and Nutrition Department, Zanjan University of Medical Sciences, Zanjan Sh Rezazadeh شمسعلی رضازاده 100319475328460038132 100319475328460038132 No Institute of Medicinal Plants, ACECR, Tehran Institute of Medicinal Plants, ACECR, Tehran E Barkhordari برخورداری 100319475328460038133 100319475328460038133 No Tehran University of Medical Science, Tehran Tehran University of Medical Science, Tehran N Hekmat-Nazemi حکمت نظامی 100319475328460038134 100319475328460038134 No Institute of Medicinal Plants, ACECR, Tehran Institute of Medicinal Plants, ACECR, Tehran M Baghaei بقایی 100319475328460038135 100319475328460038135 No Cosmetics Industry Researcher, Tehran Cosmetics Industry Researcher, Tehran S Bokaie بکایی 100319475328460038136 100319475328460038136 No Faculty of Veterinary, University of Tehran, Tehran Faculty of Veterinary, University of Tehran, Tehran H Rastegar حسین رستگار mh_rastegar@yahoo.com 100319475328460038137 100319475328460038137 Yes Ministry of Health and Medical Education, Food & Drug Laboratory Research Center, Tehran Ministry of Health and Medical Education, Food & Drug Laboratory Research Center, Tehran