en Treatment Effects of Ginger Rhizome & Extract of Carrot seed on Diabetic Nephropathy in Rat فارماكولوژی و سم شناسی Pharmacology & Toxicology پژوهشی Research <div dir="ltr"> <p style="text-align: justify;"><strong>Background: </strong>Antioxidants have essential effect on tissue regeneration after cells injury. Enhanced oxidative stress and changes in antioxidant capacity are considered to play an important role in the pathogenesis of chronic diabetes mellitus. Ginger rhizome and carrot seed are strong antioxidants and long-term treatment of Streptozotocin induced&ndash;diabetic animals with these herbs, has been shown to reduce oxidative stress.</p> <p style="text-align: justify;"><strong>Objective:</strong> Evaluation to treatment effect of Ginger rhizome and extract of carrot seed on nephropathy after diabetes inducement.</p> <p style="text-align: justify;"><strong>Methods:</strong> Wistar male rat (n=70) were allocated into seven groups, control group, carrot seed extract group, ginger group, control- Diabetic group received 55mg/kg (IP) streptozotocin (STZ), treatment diabetic group that received carrot seed extract, treatment diabetic group that received ginger and treatment diabetic group that received carrot seed extract plus ginger. Animals were kept in standard condition. In 30 day after inducing diabetes, 5ml blood were collected for analyzing of TAC and MDA levels, and kidney tissues of Rats were removed in all groups then prepared for analysis.</p> <p style="text-align: justify;"><strong>Results:</strong> Pathological changes in diabetic group which received carrot seed and ginger together was decreased compared to control group. The rate of serum TAC significantly increased in diabetic groups which received carrot seed and ginger together significantly in comparison to control-diabetic group (p<0.05).</p> <div style="text-align: justify;"><strong>Conclusion:</strong> Since in our study 25 mg/kg carrot seed extract and 100 mg/kg ginger have prevented kidney tissue injury by reducing level of Reactive Oxygen Species (ROS) in serum, so it seems that using it can be effective for treatment nephropathy in Diabetic rats.</div> </div> <p style="text-align: justify;"><strong>Background: </strong>Antioxidants have essential effect on tissue regeneration after cells injury. Enhanced oxidative stress and changes in antioxidant capacity are considered to play an important role in the pathogenesis of chronic diabetes mellitus. Ginger rhizome and carrot seed are strong antioxidants and long-term treatment of Streptozotocin induced&ndash;diabetic animals with these herbs, has been shown to reduce oxidative stress.</p> <p style="text-align: justify;"><strong>Objective:</strong> Evaluation to treatment effect of Ginger rhizome and extract of carrot seed on nephropathy after diabetes inducement.</p> <p style="text-align: justify;"><strong>Methods:</strong> Wistar male rat (n=70) were allocated into seven groups, control group, carrot seed extract group, ginger group, control- Diabetic group received 55mg/kg (IP) streptozotocin (STZ), treatment diabetic group that received carrot seed extract, treatment diabetic group that received ginger and treatment diabetic group that received carrot seed extract plus ginger. Animals were kept in standard condition. In 30 day after inducing diabetes, 5ml blood were collected for analyzing of TAC and MDA levels, and kidney tissues of Rats were removed in all groups then prepared for analysis.</p> <p style="text-align: justify;"><strong>Results:</strong> Pathological changes in diabetic group which received carrot seed and ginger together was decreased compared to control group. The rate of serum TAC significantly increased in diabetic groups which received carrot seed and ginger together significantly in comparison to control-diabetic group (p<0.05).</p> <div style="text-align: justify;"><strong>Conclusion:</strong> Since in our study 25 mg/kg carrot seed extract and 100 mg/kg ginger have prevented kidney tissue injury by reducing level of Reactive Oxygen Species (ROS) in serum, so it seems that using it can be effective for treatment nephropathy in Diabetic rats.</div> Carrot seed, Ginger, Nephropathy, Diabetic Rats Carrot seed, Ginger, Nephropathy, Diabetic Rats 75 80 http://jmp.ir/browse.php?a_code=A-10-176-8&slc_lang=en&sid=1 AA Khaki خاکی 100319475328460038119 100319475328460038119 No Department of Anatomical sciences, Islamic Azad University, Bonab Branch, Bonab Department of Anatomical sciences, Islamic Azad University, Bonab Branch, Bonab A Khaki خاکی arashkhaki@yahoo.com 100319475328460038120 100319475328460038120 Yes Department of Veterinary Pathology, Islamic Azad University, Tabriz Branch, Tabriz Department of Veterinary Pathology, Islamic Azad University, Tabriz Branch, Tabriz HR Ahmadi-Ashtiani حمیدرضا احمدی آشتیانی 100319475328460038121 100319475328460038121 No Clinical Biochemistry, Tarbiat-e-Modarres University, School of Medical Science, Department of Clinical Biochemistry, Tehran, Iran & Biochemistry and Nutrition Department of Zanjan Medical University, Zanjan Clinical Biochemistry, Tarbiat-e-Modarres University, School of Medical Science, Department of Clinical Biochemistry, Tehran, Iran & Biochemistry and Nutrition Department of Zanjan Medical University, Zanjan H Rastegar حسین رستگار 100319475328460038122 100319475328460038122 No Ministry of Health and Medical Education, Food & Drug Laboratory Research Center, Tehran Ministry of Health and Medical Education, Food & Drug Laboratory Research Center, Tehran Sh Rezazadeh شمسعلی رضازاده 100319475328460038123 100319475328460038123 No Institute of Medicinal Plants, ACECR, Tehran Institute of Medicinal Plants, ACECR, Tehran D Babazadeh بابازاده 100319475328460038124 100319475328460038124 No Department of Anatomical sciences, Islamic Azad University, Bonab Branch, Bonab Department of Anatomical sciences, Islamic Azad University, Bonab Branch, Bonab A Zahedi زاهدی 100319475328460038125 100319475328460038125 No Department of Veterinary Pathology, Islamic Azad University, Rasht Branch, Rasht Department of Veterinary Pathology, Islamic Azad University, Rasht Branch, Rasht Z Ghanbari قنبری 100319475328460038126 100319475328460038126 No Medical school of Islamic Azad University, Tabriz Branch, Tabriz Medical school of Islamic Azad University, Tabriz Branch, Tabriz