en Chemical Composition and Antimicrobial Activity of <i>Oliveria decumbens</i> Volatile Oil from West of Iran فارماكوگنوزی و فارماسيوتيكس Pharmacognosy & Pharmaceutics پژوهشی Research <p dir="ltr" style="text-align: justify;"><strong>Background:</strong> <i>Oliveria decumbens</i> Vent. is an endemic plant of Flora Iranica that grows in high temperature areas of south and west of Iran. It is used for indigestion, diarrhea, abdominal pain and fever in traditional medicine.</p> <p dir="ltr" style="text-align: justify;"><strong>Objective:</strong> In this investigation, chemical composition and antimicrobial effects of <i>Oliveria decumbens</i> has been studied.</p> <p dir="ltr" style="text-align: justify;"><strong>Methods:</strong> The essential oil of aerial parts of <i>Oliveria decumbens</i> was obtained by hydrodistillation and analyzed by GC-MS. The antimicrobial activity of the essential oil was also investigated against three Gram positive bacteria, two Gram negative bacteria and two fungi using disc diffusion method.</p> <p dir="ltr" style="text-align: justify;"><strong>Results:</strong> 10 components were identified in the essential oil of <i>Oliveria decumbens</i>. The main components were &gamma;-terpinene, myristicin, thymol, &rho;-cymene and carvacrol. The essential oil showed high antimicrobial activity against Gram-positive bacteria, <i>Escherichia coli</i>, <i>Aspergilus niger</i> and <i>Candida albicans</i> but low antibacterial effect against <i>Pseudomonas aeroginosa</i>.</p> <div dir="ltr" style="text-align: justify;"><strong>Conclusion:</strong> High amount of thymol, carvacrol and &rho;-cymene in <i>Oliveria decumbens</i> essential oil may be a reason of antimicrobial effects of the plant and the plant essential oil can be considered as a natural source of preservatives in food and cosmetic industries.</div> <p style="text-align: justify;"><strong>Background:</strong> <i>Oliveria decumbens</i> Vent. is an endemic plant of Flora Iranica that grows in high temperature areas of south and west of Iran. It is used for indigestion, diarrhea, abdominal pain and fever in traditional medicine.</p> <p style="text-align: justify;"><strong>Objective:</strong> In this investigation, chemical composition and antimicrobial effects of <i>Oliveria decumbens</i> has been studied.</p> <p style="text-align: justify;"><strong>Methods:</strong> The essential oil of aerial parts of <i>Oliveria decumbens</i> was obtained by hydrodistillation and analyzed by GC-MS. The antimicrobial activity of the essential oil was also investigated against three Gram positive bacteria, two Gram negative bacteria and two fungi using disc diffusion method.</p> <p style="text-align: justify;"><strong>Results:</strong> 10 components were identified in the essential oil of <i>Oliveria decumbens</i>. The main components were &gamma;-terpinene, myristicin, thymol, &rho;-cymene and carvacrol. The essential oil showed high antimicrobial activity against Gram-positive bacteria, <i>Escherichia coli</i>, <i>Aspergilus niger</i> and <i>Candida albicans</i> but low antibacterial effect against <i>Pseudomonas aeroginosa</i>.</p> <div style="text-align: justify;"><strong>Conclusion:</strong> High amount of thymol, carvacrol and &rho;-cymene in <i>Oliveria decumbens</i> essential oil may be a reason of antimicrobial effects of the plant and the plant essential oil can be considered as a natural source of preservatives in food and cosmetic industries.</div> <,i>,Oliveria decumbens<,/i>,, Essential oil, Antimicrobial activity, GC-MS <,i>,Oliveria decumbens<,/i>,, Essential oil, Antimicrobial activity, GC-MS 39 44 http://jmp.ir/browse.php?a_code=A-10-200-3&slc_lang=en&sid=1 H Hajimehdipoor هما حاجی مهدی پور 100319475328460038096 100319475328460038096 No Traditional Medicine and Materia Medica Research Center, Shahid Beheshti University of Medical Sciences, Tehran Traditional Medicine and Materia Medica Research Center, Shahid Beheshti University of Medical Sciences, Tehran N Samadi نسرین صمدی 100319475328460038097 100319475328460038097 No Department of Food and Drug Control, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran Department of Food and Drug Control, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran V Mozaffarian ولی ا... مظفریان 100319475328460038098 100319475328460038098 No Research Institute of Forests and Rangelands, Tehran, Iran Research Institute of Forests and Rangelands, Tehran, Iran N Rahimifard ناهید رحیمی فرد 100319475328460038099 100319475328460038099 Yes Food and Drug Laboratory Research Center and Food and Drug Control Laboratories, MOH & ME, Tehran Food and Drug Laboratory Research Center and Food and Drug Control Laboratories, MOH & ME, Tehran Sh Shoeibi شهرام شعیبی 100319475328460038100 100319475328460038100 No Food and Drug Laboratory Research Center and Food and Drug Control Laboratories, MOH & ME, Tehran Food and Drug Laboratory Research Center and Food and Drug Control Laboratories, MOH & ME, Tehran M Pirali Hamedani مرتضی پیرعلی همدانی 100319475328460038101 100319475328460038101 No Department of Medicinal Chemistry and Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran Department of Medicinal Chemistry and Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran