en فارماكوگنوزی و فارماسيوتيكس Pharmacognosy & Pharmaceutics پژوهشی Research <div style="text-align: justify;"><b><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">Background:</span></span></b> <span style="font-size:10.0pt"><span style="background:white"><span new="" roman="" style="font-family:" times=""><span style="color:black">Polycystic ovary syndrome (PCOS) is the most common cause of anovulation and one of the main causes of infertility. Management varies with emphasis on the role of herbal medicines in the treatment of polycystic ovary syndrome (PCOS) compared to medical therapy. </span></span></span></span><b><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">Objective:</span></span></b> <span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">The aim of this study is to compare </span></span><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">the herbal regimen</span></span><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""> <i>Vitex agnus-castus </i>var. + <i><span style="background:white"><span style="color:black">Foeniculum vulgare </span></span></i><span style="background:white"><span style="color:black">Mill.</span></span> +<i>Portula caoleracea </i>L)</span></span> <span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">with a medical regimen (spironolactone + cyproterone acetate with ethinyl estradiol)<b> </b></span></span><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">in </span></span><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">polycystic ovarian syndrome patients. <b>Method: </b><span style="background:white"><span style="color:black">The clinical trial, which compared two groups of women with polycystic ovary syndrome (PCOS), included 64 participants aged 18 to 42 years, all referred to a gynecological clinic. </span></span>In a clinical study, the division of patients into case and control groups using random assignment so that both groups are as similar as possible. The<span style="background:white"><span style="color:black"> control group receives a </span></span>medical<span style="background:white"><span style="color:black"> regimen that is compared to the herbal </span></span>regimen<span style="background:white"><span style="color:black"> of the case group. </span></span><b>Results: </b><span style="background:white"><span style="color:black">The study did not show any statistically significant difference in Follicle-Stimulating Hormone (FSH), Thyroid-Stimulating Hormone (TSH), or Dehydroepiandrosterone Sulfate (DHEA-S) levels between the control and case groups after the intervention </span></span>(P > 0.05).<span style="background:white"><span style="color:black">&quot; the LH level has declined significantly after the intervention in the case group&quot; is a common finding in this research </span></span>(P = 0.001). The severity or existence of hirsutism (excessive hair growth in androgen-dependent areas of the female body) did not vary significantly between the two groups being compared (P> 0.05). The case group showed a significant reduction in the rate of hair loss (P = 0.001).Ovarian ultrasound Showed Formation of dominant follicles in case and control groups. <b>Conclusion: </b>The Herbal regimen was as effective as the phamacological regimen<i>. Vitex agnus-castus</i> and Fennel, known for their phytoestrogenic properties, induce negative feedback of luteinizing hormone with long-term use, leading to decrease in testosterone production. The synergistic effect of <i>Vitax agnus-castus</i>, Fennel and Purslane combination reduce testosterone levels and accelerates the treatment of PCOS.</span></span></div> PCOS, Hirsutism, Vitex agnus-castus, Foeniculum vulgare, Portula caoleracea, Pharmacological regimen 59 69 http://jmp.ir/browse.php?a_code=A-10-214-6&slc_lang=en&sid=1 Athar Rasekh jahromi drrasekh@yahoo.com 100319475328460049036 100319475328460049036 No Obstetrician and Gynecologist, Women's Health and Diseases Research Center of Jahrom University of Medical Sciences, Jahrom, Iran Gholamreza Bakhshi Khaniki bakhshi@pnu.ac.ir 100319475328460049037 100319475328460049037 No Department of Biology, Payame Noor University, Tehran, Iran Tahereh Nasr arashbaghai1393@gmail.com 100319475328460049038 100319475328460049038 No Department of Biology, Payame Noor University, Tehran, Iran Fatemeh Shahi Sadrabadi Biology_pnu@yahoo.com 100319475328460049039 100319475328460049039 No Department of Biology, Payame Noor University, Tehran, Iran Sima Nasri s_nasri2000@yahoo.com 100319475328460049040 100319475328460049040 Yes Department of Biology, Payame Noor University, Tehran, Iran