en فارماكوگنوزی و فارماسيوتيكس Pharmacognosy & Pharmaceutics پژوهشی Research <div style="text-align: justify;"><b><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">Background:</span></span></b><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""> The rising prevalence of diabetes mellitus underscores the need for safer therapeutic options, including natural products. <i>Morus alba</i> Linn leaf extract (MAE), a traditional remedy and the key component of the herbal product DIDALA, has been investigated for its potential antidiabetic properties. <b>Objective:</b> This study aimed to investigate the hypoglycemic and lipid-modulating effects of MAE in a type 2 diabetes (T2DM) experimental model induced by a high-fat diet (HFD) and streptozotocin (STZ) in mice. <b>Methods:</b> T2DM was induced in male Swiss mice by 8 weeks of an HFD followed by an intraperitoneal injection of STZ at 100 mg/kg. Diabetic mice were orally administered for 14 days with either a low dose MAE (0.8208 g/kg/day), a high dose MAE (2.4624 g/kg/day), or Gliclazide (80 mg/kg/day) as a positive control. Outcomes assessed included fasting blood glucose, lipid profiles (total cholesterol, LDL-cholesterol), liver and pancreatic malondialdehyde (MDA) as a marker of oxidative stress, and histological examination. <b>Results:</b> The low dose of MAE significantly reduced fasting blood glucose and improved lipid profile by lowering total cholesterol and LDL-cholesterol, with outcomes comparable to the Gliclazide group. It also reduced liver and pancreatic MDA levels, indicating decreased oxidative stress, and ameliorated histopathological alterations in the liver and pancreas. The high-dose MAE exerted less pronounced effects on glucose levels but still demonstrated some lipid and oxidative stress benefits. <b>Conclusion:</b> MAE, particularly at the lower dose, exhibits promising hypoglycemic and lipid-lowering effects in a HFD/STZ-induced T2DM mouse model, supporting its potential as a natural therapeutic candidate for diabetes management. Further studies should explore dose optimization, long-term efficacy, safety, and mechanisms of action.</span></span></div> Antioxidant activity, Diabetic mice, High-fat diet, Morus alba Linn, Streptozotocin 45 59 http://jmp.ir/browse.php?a_code=A-10-7058-1&slc_lang=en&sid=1 Ha Thi Thu Nguyen hachiyhct005@gmail.com 100319475328460049186 100319475328460049186 No Department of Traditional Medicine, Hanoi Medical University, Hanoi, Vietnam Ngoc Kim Nguyen kimngoc@hmu.edu.vn 100319475328460049187 100319475328460049187 No Department of Traditional Medicine, Hanoi Medical University, Hanoi, Vietnam Hang Thi Thu Dinh dinhthuhang@hmu.edu.vn 100319475328460049188 100319475328460049188 No Department of Pharmacology, Hanoi Medical University, Hanoi, Vietnam Quang Vinh Trinh quangtv1511@gmail.com 100319475328460049189 100319475328460049189 No Department of Pharmacology, Hanoi Medical University, Hanoi, Vietnam Quynh Thi Nhu Nguyen nhuquynh1395@gmail.com 100319475328460049190 0009-0000-9115-0693 No Department of Pharmacology, Hanoi Medical University, Hanoi, Vietnam Ha Thi Thanh Nguyen ntthanhha@hmu.edu.vn 100319475328460049191 100319475328460049191 No Department of Pharmacology, Hanoi Medical University, Hanoi, Vietnam Nam Vu vunamyhct@gmail.com.vn 100319475328460049192 0009-0003-5425-7469 No Department of Traditional Medicine, National Hospital of Traditional Medicine, Hanoi, Vietnam Nghia Trong Duong dtnghia72@gmail.com 100319475328460049193 0009-0000-8321-4925 No Department of Traditional Medicine, National Hospital of Traditional Medicine, Hanoi, Vietnam Phong Xuan Pham pxphongyhct@gmail.com 100319475328460049194 0009-0000-8817-6040 No Department of Traditional Medicine, Military Institute of Traditional Medicine, Hanoi, Vietnam Van Anh Thi Pham phamvananh@hmu.edu.vn 100319475328460049195 100319475328460049195 Yes Department of Pharmacology, Hanoi Medical University, Hanoi, Vietnam