en اثر یک فرمول استاندارد شده چند گیاهی برای درد مرتبط با اندومتریوز: یک کارآزمایی بالینی تصادفی دوسوکور کنترل شده با دارونما داروسازی سنتی و طب سنتی Traditional Pharmacy & Traditional Medicine پژوهشی Research <div style="text-align: justify;"><b><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">Background:</span></span></b><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""> Dysmenorrhea, dyspareunia and endometriosis-associated pain are considered the main complications in young women with endometriosis. Proscur capsule contains several traditional herbal medicines that have shown anti-inflammatory, antioxidant, anti-androgenic, anti-estrogenic, pelvic pain reducing and analgesic effects in previous pre-clinical and clinical studies. <b>Objective:</b> This study aimed to investigate the clinical efficacy and safety of a standardized polyherbal formulation (proscur) for endometriosis-associated pain in young women with endometriosis. <b>Methods:</b></span></span> <span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">This study was a single-center, randomized, double-blinded, placebo-controlled, clinical trial. A total of 90 patients aged 20&ndash;45 years with endometriosis-associated pain were enrolled. Participants were randomly assigned to the proscur or placebo groups in a ratio of 1:1 and efficacy evaluation was conducted at day 30, 60 and 90. The participants orally administered proscur or placebo two times a day for 12 weeks. The study outcomes were measured based on a change of </span></span><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">visual analogue scale (VAS)</span></span><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""> score and the short form endometriosis health profile questionnaire (EHP-5). <b>Results:</b> We observed an increase in pain relief in women who receive proscur. The serum measures of CA-125 declined in those who received proscur. Intervention was well tolerated, and no serious adverse events occurred. <b>Conclusions:</b></span></span> <span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">Our study showed that proscur relieved endometriosis-associated pain and CA-125 level with minimal side-effects after treatment. Therefore, proscur combined with standard medical therapy could provide more clinical benefits for patients with endometriosis-associated pain.</span></span></div> Endometriosis, Pelvic pain, Herbal medicine, Quality of life 75 87 http://jmp.ir/browse.php?a_code=A-10-7038-1&slc_lang=en&sid=1 Elham Akhtari الهام اختری eli.akhtari@gmail.com 100319475328460048070 100319475328460048070 No Institute for Studies in Medical History, Persian and Complementary Medicine, Iran University of Medical Sciences, Tehran, Iran; Department of Traditional Medicine, School of Persian Medicine, Iran University of Medical Sciences, Tehran, Iran موسسه مطالعات تاریخ پزشکی، طب ایرانی و مکمل، دانشگاه علوم پزشکی ایران، تهران، ایران؛ گروه طب سنتی، دانشکده طب ایرانی، دانشگاه علوم پزشکی ایران، تهران، ایران Fataneh Hashem-Dabaghian فتانه هاشم دباغیان dabaghian.f@iums.ac.ir 100319475328460048071 100319475328460048071 No Institute for Studies in Medical History, Persian and Complementary Medicine, Iran University of Medical Sciences, Tehran, Iran; Department of Traditional Medicine, School of Persian Medicine, Iran University of Medical Sciences, Tehran, Iran موسسه مطالعات تاریخ پزشکی، طب ایرانی و مکمل، دانشگاه علوم پزشکی ایران، تهران، ایران؛ گروه طب سنتی، دانشکده طب ایرانی، دانشگاه علوم پزشکی ایران، تهران، ایران Amirhossein Jamshidi امیرحسین جمشیدی jamshidiam@yahoo.com 100319475328460048072 100319475328460048072 No Institute for Studies in Medical History, Persian and Complementary Medicine, Iran University of Medical Sciences, Tehran, Iran; Department of Traditional Pharmacy, School of Persian Medicine, Iran University of Medical Sciences, Tehran, Iran موسسه مطالعات تاریخ پزشکی، طب ایرانی و مکمل، دانشگاه علوم پزشکی ایران، تهران، ایران؛ گروه داروسازی سنتی، دانشکده پزشکی ایرانی، دانشگاه علوم پزشکی ایران، تهران، ایران Akram Fallah اکرم فلاح akram.fallah@gmail.com 100319475328460048073 100319475328460048073 No Institute for Studies in Medical History, Persian and Complementary Medicine, Iran University of Medical Sciences, Tehran, Iran; Department of Traditional Medicine, School of Persian Medicine, Iran University of Medical Sciences, Tehran, Iran; Student Research Committee, Iran University of Medical Sciences, Tehran, Iran موسسه مطالعات تاریخ پزشکی، طب ایرانی و مکمل، دانشگاه علوم پزشکی ایران، تهران، ایران؛ گروه طب سنتی، دانشکده طب ایرانی، دانشگاه علوم پزشکی ایران، تهران، ایران؛ کمیته تحقیقات دانشجویی، دانشگاه علوم پزشکی ایران، تهران، ایران Majid Dadmehr مجید دادمهر majiddadmehr@yahoo.com 100319475328460048074 100319475328460048074 Yes Institute for Studies in Medical History, Persian and Complementary Medicine, Iran University of Medical Sciences, Tehran, Iran; Department of Traditional Medicine, School of Persian Medicine, Iran University of Medical Sciences, Tehran, Iran موسسه مطالعات تاریخ پزشکی، طب ایرانی و مکمل، دانشگاه علوم پزشکی ایران، تهران، ایران؛ گروه طب سنتی، دانشکده طب ایرانی، دانشگاه علوم پزشکی ایران، تهران، ایران