en داروسازی سنتی و طب سنتی Traditional Pharmacy & Traditional Medicine پژوهشی Research <div style="text-align: justify;"><b><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">Background</span></span></b><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">: Historical medical and pharmacological manuscripts describe various pharmaceutical applications of medieval Persian medicine. One of the known forms of application for therapeutic purposes via topical or systemic administration is herbal oils. &ldquo;</span></span><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">Rose fixed oil&rdquo; (<i>Rosa&times;damascena</i> Herrm.) has traditional applications in the management of inflammation and pain due to ailment conditions such as inflammatory bowel disease, hemorrhoid, earache, and gastro-esophageal reflux diseases topically or orally. <b>Objective</b>: This study evaluated mechanism of analgesic and anti-inflammatory effects of &ldquo;Rose fixed oil&rdquo; by animal models.</span></span> <b><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">Methods</span></span></b><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">: 50 grams of dried powdered petals of <i>R.</i>&times;<i>damascena</i> were weighed and soaked with 800ml distilled water for 24 hours. The mixture was heated for 70 minutes. Writhing, Tail flick, Hot plate, and carrageenan tests were used for the evaluation of the anti-inflammatory and analgesic effects of rose oil. The level of TNF-&alpha; and MPO activity in serum was measured. <b>Results</b>: &ldquo;Rose fixed oil&rdquo; 400mg/kg in all tests have been shown a significant effect. &ldquo;Rose fixed oil&rdquo; could decrease TNF-&alpha; and MPO. Previous studies demonstrated Rose extract can inhibit inflammation in animal models and clinical trials. &ldquo;Rose fixed oil&rdquo; in some studies has been shown an anti-inflammatory effect. The results of this study confirmed anti-inflammatory and analgesic effects of &ldquo;Rose fixed oil&rdquo; as a Persian medicine preparation. <b>Conclusion</b>: </span></span><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">The main finding of this study was that &ldquo;Rose fixed oil&rdquo; <i>as</i> a Persian medicine preparation, possesses analgesic and anti-inflammatory effects through peripheral and central analgesic activity, and modulation of acute and chronic inflammation mediators in a dose-dependent manner.</span></span></div> Rose oil, Rosa×damascena, Inflammation, Anti-nociceptive, Tail flick, Hot plate 72 82 http://jmp.ir/browse.php?a_code=A-10-681-1&slc_lang=en&sid=1 Samane Jahanabadi sjahanabadi@yahoo.com 100319475328460048569 100319475328460048569 No Department of Pharmacology and Toxicology, Faculty of Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, Iran; Pharmaceutical Science Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Erfaneh Akhavanfarid erfanehfarid0@gmail.com 100319475328460048570 100319475328460048570 No School of Pharmacy, Shahid Sadoughi University of Medical Science Health Services, Yazd, Iran Hamed Mahmoodian H.mahmoodian@meybod.ac.ir 100319475328460048571 100319475328460048571 No Management Department, Meybod University, Meybod, Iran Mobina Ghiasirad mobina.ghiasi79@gmail.com 100319475328460048572 100319475328460048572 No School of Pharmacy, Shahid Sadoughi University of Medical Science Health Services, Yazd, Iran Rahele Zareshahi rahele.zareshahi@gmail.com 100319475328460048573 0000.0002.3577.8037 Yes Department of Pharmacognosy, School of Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, Iran; Herbal Medicines Research Center, School of Pharmacy, Shahid Sadoughi University of Medical Science Health Services, Yazd, Iran