en گياهان دارویی Medicinal Plants مروری Review <div style="text-align: justify;"><b><span style="font-size:10.0pt"><span style="background:white"><span new="" roman="" style="font-family:" times=""><span style="color:#202122">Background: </span></span></span></span></b><span style="font-size:10.0pt"><span style="background:white"><span new="" roman="" style="font-family:" times=""><span style="color:#202122">Barberry (<i>Berberis </i>L<i>.</i>) is a well-known fruit traditionally used in various ethnomedical systems, including Ayurveda and Traditional Persian Medicine (TPM), for its nutritionaland therapeutic properties. <b>Objective: </b>This study aims to provide a comprehensive overview of the traditional medicinal uses, phytochemical composition, and pharmacological effects of barberry. <b>Method: </b>A systematic review was conducted by examining traditional Persian medicine texts and electronic literature on traditional medicine. Additionally, electronic databases were searched for scholarly articles focusing on the pharmacological activities and phytochemical components of barberry. <b>Results: </b>Phytochemical analysis revealed the presence of essential oils, micronutrients, macronutrients, phytosterols, and various phenolic compounds. Pharmacological studies demonstrate that barberry possesses diverse biological activities, including anti-cancer, antioxidant, cardiometabolic protective, antimicrobial, hepatoprotective, anti-inflammatory, anxiolytic, nootropic, and neuroprotective effects. <b>Conclusion: </b>Although barberry shows promising therapeutic potential, further clinical trials and meta-analyses are required to confirm its efficacy in medical applications.</span></span></span></span></div> Berberis sp., Barberry, Functional food, Traditional Persian Medicine 1 11 http://jmp.ir/browse.php?a_code=A-10-6982-1&slc_lang=en&sid=1 Marziye Bayat parisa.bayat9372@gmail.com 100319475328460048984 100319475328460048984 No School of Persian Medicine, Iran University of Medical Sciences, Tehran, Iran Amirhossein Jamshidi jamshidiam@yahoo.com 100319475328460048985 100319475328460048985 No Institute for Studies in Medical History, Persian and Complementary Medicine &School of Persian Medicine, Iran University of Medical Sciences, Tehran, Iran Hoorieh Mohammadi-Kenari mohammadikenari.h@iums.ac.ir 100319475328460048986 100319475328460048986 No Institute for Studies in Medical History, Persian and Complementary Medicine &School of Persian Medicine, Iran University of Medical Sciences, Tehran, Iran Ali Ghobadi ghobadi.a@iums.ac.ir 100319475328460048987 100319475328460048987 Yes School of Persian Medicine, Iran University of Medical Sciences, Tehran, Iran