en گياهان دارویی Medicinal Plants پژوهشی Research <div style="text-align: justify;"><b><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">Background</span></span></b><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">: </span></span><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">Diabetic neuropathy is a prevalent microvascular complication that significantly impairs patients&#39; quality of life. <b>Objective</b></span></span><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">:</span></span><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""> This study </span></span><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">examined</span></span><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""> the therapeutic effect of <i>Achillea millefolium</i> oral supplementation</span></span> <span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">on glycated hemoglobin (HbA</span></span><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">1</span></span><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">C) levels and neuropathic symptoms in individuals suffering from type 2 diabetes. </span></span><b><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">Method</span></span></b><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">: </span></span><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">In a triple-blind randomized clinical trial, 70 patients with type 2 diabetes attending a diabetes clinic in Rafsanjan were enrolled through convenience sampling and placed into intervention and placebo groups using the minimization technique. The patients in the intervention group received one capsule having 500 mg of aqueous extract of <i>A. millefolium</i>. They used the capsules daily for three months.</span></span> <span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">The patients in the placebo group received identically appearing capsules filled with 500 mg of cellulose. Outcomes were assessed with the </span></span><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">Michigan Neuropathy Screening Instrument (MNSI)</span></span><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""> and HbA</span></span><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">1</span></span><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">C testing, both administered at baseline and after the 3-month intervention period. The data were processed using SPSS-22 software. <b>Results</b>: Post-intervention analysis revealed a decrease in HbA1C levels in the <i>A. millefolium</i> group in comparison with the placebo group, but no significant intergroup difference was observed (P = 0.17). However, the participants in the intervention group showed a significant improvement in neuropathy symptoms relative to the placebo group (P = 0.001). <b>Conclusions</b>: The findings suggest that oral administration of <i>Achillea millefolium</i> can effectively alleviate neuropathic symptoms in patients with type 2 diabetes. Nevertheless, further clinical studies need to explore its potential effects on glycemic control.</span></span></div> Achillea millefolium, HbA1C, Diabetic Neuropathy, Type 2 Diabetes, Persian Medicine 46 58 http://jmp.ir/browse.php?a_code=A-10-1539-5&slc_lang=en&sid=1 Elham Basirat elham.basirat7262@gmail.com 100319475328460049031 0009-0003-9677-7745 No Medical Surgical Nursing Student, Student Research Committee, School of Nursing and Midwifery, Rafsanjan University of Medical Sciences, Rafsanjan, Iran Maryam Karimifard karimifardmaryam6@gmail.com 100319475328460049032 100319475328460049032 No Department of Internal Medicine, School of Medicine; Non-Communicable Diseases Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran Fatemeh Ayoobi ayoobi.fatemeh@gmail.com 100319475328460049033 100319475328460049033 No Occupational Safety and Health Research Center, NICICO, World Safety Organization and Rafsanjan University of Medical Sciences, Rafsanjan, Iran Zahra Jamali zahrajamali2959@gmail.com 100319475328460049034 100319475328460049034 No Non-Communicable Diseases Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran Tabandeh Sadeghi t.sadeghi@rums.ac.ir 100319475328460049035 100319475328460049035 Yes Department of Pediatric Nursing, School of Nursing and Midwifery; Non-Communicable Diseases Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran