en گياهان دارویی Medicinal Plants پژوهشی Research <div style="text-align: justify;"><b><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">Background: </span></span></b><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">Antimicrobial activity has been reported against a range of bacteria, including multidrug-resistant strains for silver nanoparticles (AgNPs) due to penetration of NPs into the cell. AgNPs can be used in combination with other antibacterial agents to create a synergistic effect.&nbsp;</span></span><b><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">Objective:</span></span></b> <span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">The present work aims at the preparation of AgNPs in methanol extracts of</span></span><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""> the dried bark powder</span></span><span lang="EN-IN" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""> of </span></span><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">two </span></span><span lang="EN-IN" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">medicinally important</span></span><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""> plants, viz., </span></span><i><span lang="EN-IN" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">Pongamiapinnata (PP) </span></span></i><span lang="EN-IN" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">and <i>Azadirachtaindica (AI)</i></span></span><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""> and their </span></span><span lang="EN-IN" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">therapeutic uses. </span></span><b><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">Method:</span></span></b><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""> UV-visible, FTIR spectral techniques and SEM images were used to characterize the NPs.</span></span> <span style="font-size:10.0pt"><span style="background:white"><span new="" roman="" style="font-family:" times=""><span style="color:black">These bio-NPs were tested for this response against mycobacteria such as </span></span></span></span><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">Streptomycin and Fluconazole<span style="background:white"><span style="color:black">, viruses, bacteria, and fungi. </span></span><b>Results:</b> </span></span><span lang="EN-IN" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">A</span></span><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">ntibacterial activity, antifungal activity and detailed molecular interaction between the therapeutic constituents of <i>PP </i>and </span></span><i><span lang="EN-IN" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">A</span></span><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">I</span></span></i><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""> against Human Mixtard Insulin (HMI) and Histamine were studied by <i>in silico</i> docking analysis. The antimicrobial studies of both <i>PP</i> and <i>AI</i> yielded positive results in our attempt to investigate the mycobacterial study against two human pathogenic organisms. <b>Conclusion:</b> Extensive i<i>n-silico</i> docking study showed that the decreasing order of non-covalent interactions of four therapeutic components is Isopongachromene > Karanjin > Quercetin > Azadirachtin against Insulin and Isopongachromene > Azadirachtin > Karanjin > Quercetin against Histamine.&nbsp;&nbsp; </span></span></div> Nanomaterials, Phytochemical, Antimicrobial, Antidiabetic, In-Silico docking analysis 81 101 http://jmp.ir/browse.php?a_code=A-10-6938-1&slc_lang=en&sid=1 Mulaguri Susairaj Veena Anasthasia ajayveena10@gmail.com 100319475328460049044 100319475328460049044 No Department of Chemistry, Loyola College, Chennai-600 034, India Chokkalingam Mansiya cmansiya@gmail.com 100319475328460049045 100319475328460049045 No Department of Chemistry, SDNB Vaishnav College for Women, Chennai-600 044, India Venu Kannappan vkannappan48@gmail.com 100319475328460049046 100319475328460049046 No Department of Chemistry, Presidency College, Chennai-600 005, Tamil Nadu, India. A. Justin Adaikala Baskar justin@loyolacollege.edu 100319475328460049047 100319475328460049047 Yes 1Department of Chemistry, Loyola College, Chennai-600 034, India