en گياهان دارویی Medicinal Plants پژوهشی Research <div style="text-align: justify;"><b><span lang="EN-GB" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:#231f20">Background:</span></span></span></b><span lang="EN-GB" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:#231f20"> Throughout many decades, researchers all around the world still extensively search for treatment strategies for Alzheimer&#39;s disease. Dispute the small number of medicines that can be used for the treatment, the side effects, and the only symptomatic treatments of the drug, which makes the necessity of finding new sources of drugs from plant sources a critical movement. <b>Objective: </b>In this research, we investigate the potential of 33 traditional medicines plants from Indonesia for their acetylcholinesterase inhibitor and antioxidant properties. <b>Methods:</b>&nbsp;The inhibitory potential of acetylcholinesterase was carried out using spectrophotometry using acetylcholine as a substrate and antioxidant activity was measured using the FRAP method. <b>Results:</b> The results indicate that among the 33 plants, only seven plants with an acetylcholinesterase inhibitor (AChEI). Those plants are </span></span></span><i><span lang="EN-GB" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">Chromolaena odorata</span></span></i><span lang="EN-GB" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">, <i>Mikania scandes</i>,<i> Piper cubeba</i>, <i>Peperomia pellucida, Persea americana, Lycium barbarum</i> and <i>Phyllanthus niruri</i>.<span style="color:#231f20">&nbsp; All the plant samples showed remarkable antioxidant potency with </span>the range of value 4.11 &ndash; 52.65 mg/mL<span style="color:#231f20">. <b>Conclusions:</b> <i>Persea americana</i> (Lauraceae) had the greatest AChEI with a value of 4.11 mg/mL, meanwhile <i>Piper cubeba</i> (Piperaceae) has the highest potency in scavenging free radicals with an FRAP Value of 10.89 mg/mL. There was no correlation between AChEI and Antioxidant potency.</span></span></span></div> Plant medicines, Acetylcholinesterase inhibitor, Antioxidant, Persea Americana, Piper cubeba 12 26 http://jmp.ir/browse.php?a_code=A-10-6929-1&slc_lang=en&sid=1 Sumi Wijaya sumi@ukwms.ac.id 100319475328460048988 100319475328460048988 Yes Faculty of Pharmacy Widya Mandala Surabaya Catholic University Indonesia, Jalan Kalisari Selatan 1 Surabaya 60112 East Java Indonesia Henry Kurnia Setiawan henry@ukwms.ac.id 100319475328460048989 100319475328460048989 No Faculty of Pharmacy Widya Mandala Surabaya Catholic University Indonesia, Jalan Kalisari Selatan 1 Surabaya 60112 East Java Indonesia