en بررسی دیدگاه‎ های سقط جنین در استفاده از <i>Achyranthes aspera</i> L. و <i>Dendrocalamus hamiltonii</i> Nees & Arn. ex Munro. در میان قبیله کربی از آسام، شمال شرقی هند گياهان دارویی Medicinal Plants پژوهشی Research <div style="text-align: justify;"><b><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:-.2pt">Background:</span></span></span></b><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:-.2pt"> The Karbi, an indigenous tribe of Assam, uses ethnomedicinal plants for unintended pregnancies. <b>Objective: </b>The present study describes two important ethnomedicinal plants (</span></span></span><i><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:-.2pt">Achyranthes aspera </span></span></span></i><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:-.2pt">L. and <i><span style="color:black">Dendrocalamus hamiltonii </span></i><span style="color:black">Nees & Arn. ex Munro</span></span></span></span><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:-.2pt">) for inducing abortion and its physicochemical and phytochemical characterization. <b>Methods:</b> Physicochemical analysis performed by simple determination techniques. <b>Results:</b> The parameters in physicochemical analysis revealed that plants are potential source of phytomedicine. The pH are slightly acidic to alkaline, signifying good value for oral administration; moisture content are in the acceptable range; highest in <i>A. aspera </i>(8.9%). The total ash content is highest in <i>A. aspera </i>(6.89 %), and higher water soluble ash (20%) signifies presence of water soluble active compounds. The value of Carr&rsquo;s index and Hausner ratio indicates the powder drugs signify good powder compressibility. Active phytocompounds identified in the plants like Methyl glyoxal, Arsenous acid tris (trimethylsilyl) Ester and </span></span></span><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:-.2pt">phenol, 3-Phenoxypropionic Acid, </span></span></span><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:-.2pt">showed potential reproductive and developmental toxicity. These compounds can be predicted as a candidate drugs as per SwissADME drugs parameters (GI absorption, BBB access, Bioavailability, P-gb substrate and drugs likeness). <b>Conclusion: </b></span></span></span><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:-.2pt">The knowledge of dosing and handling of the medicinal plants are cautiously practiced by the tribe and physicochemical properties helped to understand the nature and quality control of the herbal formulations. The ADME parameters of the compounds shows drugs likeness properties as per bioavailability radar and thus the compound identified in this two plants can be predicted as an orally active plant based drugs likely to be used as abortifacient agents.</span></span></span></div> Medicinal plants, Unintended pregnancy, Bioactive compound, Orally active drugs, Karbi tribe, Bioavailability Druglikeness 28 41 http://jmp.ir/browse.php?a_code=A-10-6859-1&slc_lang=en&sid=1 Reena Terangpi رینا ترانگپی reenaterangpi@barnagarcollege.ac.in 100319475328460048062 100319475328460048062 Yes Department of Botany, Gauhati University, Guwahati-781014, India; Department of Botany, Barnagar College, Sorbhog-781317, India گروه گیاه‎شناسی، دانشگاه گاوهاتی، گواهاتی-781014، هندوستان؛ گروه گیاه‎شناسی، کالج بارناگار، سربهوگ-781317، هندوستان Farishta Yasmin فریشتا یاسمین farishtayasmin4rs@gmail.com 100319475328460048063 100319475328460048063 No Department of Botany, Nowgong College (A), Nagaon-782001, India گروه گیاه‎شناسی، کالج نوگونگ(A)، ناگاون-782001، هندوستان