en ارزیابی اثر ضد پوسیدگی وارنیش حاوی گیاه دارویی مسواک (<i>Salvadora persica</i> L.) و بره موم بر روی دندان‌های پرمولار و مولار استخراج شده انسان گياهان دارویی Medicinal Plants پژوهشی Research <div style="text-align: justify;"><b><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">Background: </span></span></b><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">Tooth decay is the result of the activity of cariogenic microorganisms that live in dental plaque. Among these, <i>Streptococcus mutans</i> is the main factor in the development and progression of dental tissue destruction. <b>Objective: </b>The study aims to investigate the anti-caries potential of a natural compound-based varnish against <i>S. mutans </i>on a set of dental specimens.<b> Methods: </b>Fifty-four extracted human molar and premolar specimens were procured from an outpatient clinic of pediatric dentistry, Bojnurd, Iran. These teeth were cast in a silicon putty and treated with a varnish made of propolis and miswak (from twigs of <i>Salvadora persica</i> L<i>. </i>tree) ethanolic extracts, followed by incubation in a harsh acidic medium (pH 2). Then, the density of samples, antibacterial activity, buffering capacity, and fluoride release were respectively investigated using radiography, disc diffusion and microdilution tests, and pH drop challenge in acetic acid solution (PH 4).</span></span> <b><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">Results: </span></span></b><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">Overall, the varnishes protected the dental samples from dissolution in the acidic medium, as evidenced by the radiographic examination. The varnishes also exhibited remarkable antibacterial activity (inhibition zones of 3.2 &plusmn; 0.8 mm and 2.0 &plusmn; 0.2 mm for miswak and propolis varnish films), a considerable buffering capacity (pH increase from 4 to 7 within 5 minutes), and released fluoride (</span></span><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">mean 85 &micro;moles).</span></span> <b><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">Conclusion</span></span><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">:</span></span></b><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""> The application of natural compound-based varnish is strongly recommended for dental protection.</span></span></div> Dental Demineralization, Antibacterial activity, Miswak (S. persica), Propolis, Varnish 94 104 http://jmp.ir/browse.php?a_code=A-10-6827-1&slc_lang=en&sid=1 Ali Derakhshani علی درخشانی alidrakhshani375@gmail.com 100319475328460047771 0009-0004-0174-4199 No School of Dentistry, North Khorasan University of Medical Sciences, Bojnurd, Iran دانشکده دندان پزشکی، دانشگاه علوم پزشکی خراسان شمالی، بجنورد، ایران Sahereh Soltani ساهره سلطانی sahere.soltani@gmail.com 100319475328460047772 100319475328460047772 No School of Dentistry, North Khorasan University of Medical Sciences, Bojnurd, Iran دانشکده دندان پزشکی، دانشگاه علوم پزشکی خراسان شمالی، بجنورد، ایران Parastoo Zarghami Moghaddam پرستو ضرغامی مقدم parastoozarghami@yahoo.com 100319475328460047773 100319475328460047773 No Natural Products and Medicinal Plants Research Center, North Khorasan University of Medical Sciences, Bojnurd, Iran مرکز تحقیقات فرآورده‎های طبیعی و گیاهان دارویی، دانشگاه علوم پزشکی خراسان شمالی، بجنورد، ایران Samaneh Mollazadeh سمانه ملازاده samanehmollazadeh@yahoo.com 100319475328460047774 100319475328460047774 No Natural Products and Medicinal Plants Research Center, North Khorasan University of Medical Sciences, Bojnurd, Iran; Department of Medical Biotechnology, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran مرکز تحقیقات فرآورده‎های طبیعی و گیاهان دارویی، دانشگاه علوم پزشکی خراسان شمالی، بجنورد، ایران؛ گروه بیوتکنولوژی پزشکی، دانشکده پزشکی، دانشگاه علوم پزشکی خراسان شمالی، بجنورد، ایران Manouchehr Teymouri منوچهر تیموری m.teymouri@nkums.ac.ir 100319475328460047775 100319475328460047775 Yes Natural Products and Medicinal Plants Research Center, North Khorasan University of Medical Sciences, Bojnurd, North Khorasan, Iran; Department of Medical Nanotechnology, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran مرکز تحقیقات فرآورده‎های طبیعی و گیاهان دارویی، دانشگاه علوم پزشکی خراسان شمالی، بجنورد، ایران؛ گروه نانوتکنولوژی پزشکی، دانشکده پزشکی، دانشگاه علوم پزشکی خراسان شمالی، بجنورد، ایران