en مکمل ‎یاری سیلی‎ مارین، اثر تمرین ورزشی بر اختلالات متابولیکی ناشی از رژیم غذایی پرچرب را بهبود می ‎دهد گياهان دارویی Medicinal Plants پژوهشی Research <div style="text-align: justify;"><b><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">Background: </span></span></b><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">The use of dietary herbal products as potential anti-obesity agents has gained considerable traction in recent years.<b> Objective:</b> The purpose of the current study was to assess the effects of <i>silymarin</i> supplementation with and without exercise training on a high-fat diet-induced metabolic disorder in <span style="color:#131413">male Wistar rats</span>.<span style="color:#131413"> <b>Methods:</b> </span>36 male Wistar rats were divided into six groups; 1) control group with a regular diet; 2) high-fat diet (HFD); 3) HFD + <i>Silymarin</i> 25 (S25); 4) HFD + <i>Silymarin</i> 50 (S50); 5) HFD +S25 + ART (aerobic resistance training); 6) HFD + S50+ART (n = 6 for each group). HFD + S25 + ART and HFD + S50 + ART groups performed aerobic exercise three days/week and resistance exercise two days/week. Blood specimens were obtained for biochemical assessments and gene expression at the end of the 12-week intervention.</span></span> <span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">The data were analyzed using one-way ANOVAs and Tukey&rsquo;s post hoc test with SPSS21 at a significance level of P < 0.05. <b>Results:</b> <span style="color:#131413">Final body weight, the levels of glucose, insulin, and</span> <span style="color:#131413">Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) </span>in all of the treatment groups were significantly less compared with the HFD group (P < 0.05). Lipid profile was significantly improved in treatment groups in comparison with the HFD group (P < 0.05).</span></span> <span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">Leptin and Neuropeptide Y (NPY) levels were significantly lower in HFD + S50, HFD + S25 + ART, and HFD + S50 + ART groups compared to HFD group (P < 0.05).</span></span> <span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">Exercise plus <i>silymarin</i> consumption</span></span><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""> (HFD + S25 + ART and HFD + S50 + ART) increased <a name="_Hlk122715582">Peptide YY levels (PYY) </a>(P= 0.013 and P < 0.001, respectively). </span></span><b><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">Conclusion:</span></span></b><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""> Our findings suggest that combined <i>silymarin</i> consumption and exercise training is a promising non-pharmacological treatment for multiple simultaneous HFD-induced risk factors.</span></span></div> High-Fat Diet, Aerobic Resistance Exercise, Metabolic indices, Silymarin, Appetite 17 30 http://jmp.ir/browse.php?a_code=A-10-6760-1&slc_lang=en&sid=1 Behnam Roozbeh بهنام روزبه behnam.roozbeh@hakimtoos.ac.ir 100319475328460047751 100319475328460047751 Yes Department of Sport Sciences, Hakim Toos Higher Education Institute, Mashhad, Iran گروه علوم ورزشی، موسسه آموزش عالی حکیم طوس، مشهد، ایران Mohammad Mehdipoor محمد مهدی‎پور m.mehdipoor1984@yahoo.com 100319475328460047752 100319475328460047752 No Department of Sport Physiology, Faculty of Sport Sciences, University of Guilan, Rasht, Iran گروه فیزیولوژی ورزشی، دانشکده علوم ورزشی، دانشگاه گیلان، رشت، ایران Gholam Rasul Mohammad Rahimi غلام رسول محمدرحیمی rmohammadrahimi@outlook.com 100319475328460047753 100319475328460047753 No Department of Exercise Physiology, Faculty of Sports Sciences, Ferdowsi University of Mashhad, Mashhad, Iran گروه فیزیولوژی ورزشی، دانشکده علوم ورزشی، دانشگاه فردوسی مشهد، مشهد، ایران Mehrdad Fathei مهرداد فتحی mfathei@um.ac.ir 100319475328460047754 100319475328460047754 No Department of Exercise Physiology, Faculty of Sports Sciences, Ferdowsi University of Mashhad, Mashhad, Iran. گروه فیزیولوژی ورزشی، دانشکده علوم ورزشی، دانشگاه فردوسی مشهد، مشهد، ایران Tom Clifford تام کلیفورد t.clifford@lboro.ac.uk 100319475328460047755 100319475328460047755 No School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UK مدرسه علوم ورزش، فعالیت ورزشی و سلامت، دانشگاه لافبرو، لافبرو، انگلستان Bibi Pourmirza بی‎بی پورمیرزا BibiPormirza84@gmail.com 100319475328460047756 100319475328460047756 No Department of Sport Sciences, University of Ghadir Langroud, Langroud, Iran گروه علوم ورزشی، دانشگاه غدیر لنگرود، لنگرود، ایران