en Effects of <i>Danae racemosa</i> on Spermatogenesis in Rat فارماكولوژی و سم شناسی Pharmacology & Toxicology پژوهشی Research <div dir="ltr" style="text-align: justify;"><strong>Background:</strong> <em>Danae racemosa</em> is used medicinally and as a culinary spice. Its constituents are stated to have antithrombotic, antihepatotoxic, antinociceptive and antioxidant. <strong>Objective:</strong> Enhanced oxidative stress and changes in antioxidant capacity are considered to play an important role in the pathogenesis of chronic diabetes mellitus. <strong>Methods: </strong>Wistar male rat (n=30) were allocated into three groups, control (n=10) and two test groups (each of ten). Animals in test groups were subdivided into groups of 2 that received fresh extract equivalent to 200 & 400 mg/Kg/Rat/day <em>Danae racemosa </em>extract. Fresh <em>Danae racemosa </em>extract was administered with gavages for 28 consecutive days. Animals were kept in standard condition. On twenty eighth day, the testes of rats in the all groups were removed and sperm was collected from epididymis and was prepared for analysis. <strong>Results:</strong> The percentage of sperm viability and motility in both test groups significantly increased (p<0.05), but the sperm concentration significantly increased only in the group that received the high dose of <em>Danae racemosa</em> extracted, (p<0.05). It was evident that there was no difference on sperm morphology and testis weight in test groups comparing to control group. <strong>Conclusion:</strong> In our study <em>Danae racemosa</em> extract has significantly affected the sperm number and percentage of viability and motility it seems that using 400 mg/Kg/Rat/day of <em>Danae racemosa</em> extract is effective in sperm health parameters.</div> <div dir="ltr" style="text-align: justify;"><strong>Background:</strong> <em>Danae racemosa</em> is used medicinally and as a culinary spice. Its constituents are stated to have antithrombotic, antihepatotoxic, antinociceptive and antioxidant. <strong>Objective:</strong> Enhanced oxidative stress and changes in antioxidant capacity are considered to play an important role in the pathogenesis of chronic diabetes mellitus. <strong>Methods: </strong>Wistar male rat (n=30) were allocated into three groups, control (n=10) and two test groups (each of ten). Animals in test groups were subdivided into groups of 2 that received fresh extract equivalent to 200 & 400 mg/Kg/Rat/day <em>Danae racemosa </em>extract. Fresh <em>Danae racemosa </em>extract was administered with gavages for 28 consecutive days. Animals were kept in standard condition. On twenty eighth day, the testes of rats in the all groups were removed and sperm was collected from epididymis and was prepared for analysis. <strong>Results:</strong> The percentage of sperm viability and motility in both test groups significantly increased (p<0.05), but the sperm concentration significantly increased only in the group that received the high dose of <em>Danae racemosa</em> extracted, (p<0.05). It was evident that there was no difference on sperm morphology and testis weight in test groups comparing to control group. <strong>Conclusion:</strong> In our study <em>Danae racemosa</em> extract has significantly affected the sperm number and percentage of viability and motility it seems that using 400 mg/Kg/Rat/day of <em>Danae racemosa</em> extract is effective in sperm health parameters.</div> <,i>,Danae racemosa<,/i>,, Extract, Sperm, Rat <,i>,Danae racemosa<,/i>,, Extract, Sperm, Rat 87 92 http://jmp.ir/browse.php?a_code=A-10-176-7&slc_lang=en&sid=1 A Khaki A Khaki arashkhaki@yahoo.com 100319475328460038291 100319475328460038291 Yes Department of Veterinary Pathology (YRC), Islamic Azad University Tabriz Branch Department of Veterinary Pathology (YRC), Islamic Azad University Tabriz Branch F Fathiazad F Fathiazad 100319475328460038292 100319475328460038292 No Department of Pharmacognosy Tabriz University of Medical Sciences Department of Pharmacognosy Tabriz University of Medical Sciences HR Ahmadi - Ashtiani HR Ahmadi - Ashtiani 100319475328460038293 100319475328460038293 No Department of Clinical Biochemistry, School of Medical Science, Tarbiat Modarres University, Tehran, Iran; Biochemistry & Nutrition Department of Zanjan Medical University Department of Clinical Biochemistry, School of Medical Science, Tarbiat Modarres University, Tehran, Iran; Biochemistry & Nutrition Department of Zanjan Medical University H Rastgar H Rastgar 100319475328460038294 100319475328460038294 No Ministry of Health and Medical Education, Food & Drug Laboratory Research center Ministry of Health and Medical Education, Food & Drug Laboratory Research center Sh Rezazadeh Sh Rezazadeh 100319475328460038295 100319475328460038295 No Institute of Medicinal Plants, ACECR Institute of Medicinal Plants, ACECR