en Chemical Composition and Antimicrobial Activities of the Essential Oils from Flower and Leaves of <i>Lagochilus kotschyanus</i> Boiss. A New Species from Iran فارماكوگنوزی و فارماسيوتيكس Pharmacognosy & Pharmaceutics پژوهشی Research <div dir="ltr" style="text-align: justify;"><strong>Background: </strong>The genus <em>lagochilus</em>, family Lamiaceae consists of 44 species, 33 of which grow in central Asia. Only one report on the analysis of essential oil of Lagochilus species has been published. <strong>Objective:</strong> Aim of this study is to determine the chemical composition and antimicrobial activities of the hydrodistilled oil of flower and leaves of <em>Lagochilus kotschyanus</em> Boiss. of Iranian origin for the first time. <strong>Methods:</strong> The essential oils obtained by hydrodistillation from the flower and leaves of <em>L. kotschyanus</em> were analyzed by GC and GC/MS. The antimicrobial activities were determined by measuring the growth inhibitory zones (well diffusion assay).<strong> Results:</strong> The major constituents of the flower and leaf oils appeared to be myrcene (28.2% and 36.6%), &alpha;-pinene (25.9% and 29.8%) and &beta;-caryophyllene (10.3% and 9.4%), respectively. <strong>Conclusion:</strong> In <em>L. kotschyanus</em> we identified 34 components representing 95.2% and 18 constituents representing 96.3% of the flower and leaf oils, respectively. Both oils were rich in regard to monoterpene hydrocarbons (72.7% and 79.7%) respectively. The sesquiterpene fraction was relatively small, representing 19.4% and 14.1%, respectively. Antibacterial activity was measured using the growth inhibitory zones. It was found that oil from leaves and flowers of <em>L. kotschyanus</em>, and especially that of flowers, exhibited interesting antibacterial activity.</div> <div dir="ltr" style="text-align: justify;"><strong>Background: </strong>The genus <em>lagochilus</em>, family Lamiaceae consists of 44 species, 33 of which grow in central Asia. Only one report on the analysis of essential oil of Lagochilus species has been published. <strong>Objective:</strong> Aim of this study is to determine the chemical composition and antimicrobial activities of the hydrodistilled oil of flower and leaves of <em>Lagochilus kotschyanus</em> Boiss. of Iranian origin for the first time. <strong>Methods:</strong> The essential oils obtained by hydrodistillation from the flower and leaves of <em>L. kotschyanus</em> were analyzed by GC and GC/MS. The antimicrobial activities were determined by measuring the growth inhibitory zones (well diffusion assay).<strong> Results:</strong> The major constituents of the flower and leaf oils appeared to be myrcene (28.2% and 36.6%), &alpha;-pinene (25.9% and 29.8%) and &beta;-caryophyllene (10.3% and 9.4%), respectively. <strong>Conclusion:</strong> In <em>L. kotschyanus</em> we identified 34 components representing 95.2% and 18 constituents representing 96.3% of the flower and leaf oils, respectively. Both oils were rich in regard to monoterpene hydrocarbons (72.7% and 79.7%) respectively. The sesquiterpene fraction was relatively small, representing 19.4% and 14.1%, respectively. Antibacterial activity was measured using the growth inhibitory zones. It was found that oil from leaves and flowers of <em>L. kotschyanus</em>, and especially that of flowers, exhibited interesting antibacterial activity.</div> <,i>,Lagochilus kotschyanus<,/i>,, Lamiaceae, Essential oil composition, Myrcene, α-pinene, β-caryophyllene, Antimicrobial activity <,i>,Lagochilus kotschyanus<,/i>,, Lamiaceae, Essential oil composition, Myrcene, α-pinene, β-caryophyllene, Antimicrobial activity 58 63 http://jmp.ir/browse.php?a_code=A-10-194-2&slc_lang=en&sid=1 S Taban S Taban 100319475328460038273 100319475328460038273 No Department of Chemistry, Saveh Branch, Islamic Azad University Saveh Department of Chemistry, Saveh Branch, Islamic Azad University Saveh Sh Masoudi Sh Masoudi 100319475328460038274 100319475328460038274 No Department of Chemistry, Central Tehran Branch, Islamic Azad University Department of Chemistry, Central Tehran Branch, Islamic Azad University F Chalabian F Chalabian 100319475328460038275 100319475328460038275 No Department of Biology, Tehran North Campus, Islamic Azad University Department of Biology, Tehran North Campus, Islamic Azad University B Delnavaz B Delnavaz 100319475328460038276 100319475328460038276 No Department of Chemistry, Saveh Branch, Islamic Azad University Saveh Department of Chemistry, Saveh Branch, Islamic Azad University Saveh A Rustaiyan A Rustaiyan arustaiyan@yahoo.it 100319475328460038277 100319475328460038277 Yes Department of Chemistry, Science and Research Campus, Islamic Azad University Department of Chemistry, Science and Research Campus, Islamic Azad University