fa Hypoglycemic Effect of Ethanolic Extract of <i>Carum carvi</i> L. Seeds in Normal and Streptozotocin-induced Diabetic Rats فارماكولوژی و سم شناسی Pharmacology & Toxicology پژوهشی Research <div dir="ltr" style="text-align: justify;"><strong>Background:</strong> Herbal medicine has been used for many years by different cultures around the world for the treatment of diabetes. <strong>Objective:</strong> The hypoglycemic effect of caraway ethanolic extract (<em>Carum carvi</em> L.) was investigated in normal and streptozotocin-induced diabetic rats. <strong>Methods: </strong>Intraperitoneal administration of caraway ethanolic extract seeds (0.1, 0.2, 0.4 and 0.6 g/kg body wt.) on the level of serum glucose and insulin in normal and streptozotocin-induced diabetic rats were evaluated. Before administration and 1, 3 and 5 h after administrations of the ethanolic extract, blood samples were drawn from the retro-orbital sinus. Serum glucose and insulin levels were determined. <strong>Results: </strong>The results showed that the caraway ethanolic extract seeds at doses 0.2, 0.4 and 0.6 g/kg body wt. significantly decreased serum glucose and insulin in diabetic rats in 3 and 5 h but not in healthy rats. <strong>Conclusions:</strong> It could be proofed that the traditional use of caraway as a hypoglycemic agent is justified and that extract from this plant show a dose-dependent hypoglycemic activity.</div> <div dir="ltr" style="text-align: justify;"><strong>Background:</strong> Herbal medicine has been used for many years by different cultures around the world for the treatment of diabetes. <strong>Objective:</strong> The hypoglycemic effect of caraway ethanolic extract (<em>Carum carvi</em> L.) was investigated in normal and streptozotocin-induced diabetic rats. <strong>Methods: </strong>Intraperitoneal administration of caraway ethanolic extract seeds (0.1, 0.2, 0.4 and 0.6 g/kg body wt.) on the level of serum glucose and insulin in normal and streptozotocin-induced diabetic rats were evaluated. Before administration and 1, 3 and 5 h after administrations of the ethanolic extract, blood samples were drawn from the retro-orbital sinus. Serum glucose and insulin levels were determined. <strong>Results: </strong>The results showed that the caraway ethanolic extract seeds at doses 0.2, 0.4 and 0.6 g/kg body wt. significantly decreased serum glucose and insulin in diabetic rats in 3 and 5 h but not in healthy rats. <strong>Conclusions:</strong> It could be proofed that the traditional use of caraway as a hypoglycemic agent is justified and that extract from this plant show a dose-dependent hypoglycemic activity.</div> Caraway, <,i>,Carum carvi<,/i>, L., Streptozotocin, Diabetes, Rat Caraway, <,i>,Carum carvi<,/i>, L., Streptozotocin, Diabetes, Rat 106 113 http://jmp.ir/browse.php?a_code=A-10-198-1&slc_lang=fa&sid=1 A Eidi A Eidi eidi@srbiau.ac.ir 100319475328460037853 100319475328460037853 Yes Department of Biology, Science and Research Branch, Islamic Azad University Department of Biology, Science and Research Branch, Islamic Azad University M Eidi M Eidi 100319475328460037854 100319475328460037854 No Department of Biology, Varamin Branch, Islamic Azad University Department of Biology, Varamin Branch, Islamic Azad University A Haeri Rohani A Haeri Rohani 100319475328460037855 100319475328460037855 No Department of Biology, Science and Research Branch, Islamic Azad University Department of Biology, Science and Research Branch, Islamic Azad University F Basati F Basati 100319475328460037856 100319475328460037856 No Department of Biology, Science and Research Branch, Islamic Azad University Department of Biology, Science and Research Branch, Islamic Azad University