Journal of Medicinal Plants
فصلنامه گياهان دارویی
J. Med. Plants
Medical Sciences
http://jmp.ir
1
admin
2717-204X
2717-2058
10.61882/jmp
14
8888
13
en
jalali
1399
3
1
gregorian
2020
6
1
19
74
online
1
fulltext
fa
اثر ضدالتهابی و آنتیاکسیدانی اسانس گل محمدی <i>Rosa damascena</i> Mill. بر روی آسیب ریوی ناشی از مدل CLP
The anti-inflammatory and antioxidant effects of <i>Rosa damascena</i> Mill. essential oil on the lung injury in the CLP model
گياهان دارویی
Medicinal Plants
پژوهشی
Research
<div style="text-align: justify;"><strong><span dir="RTL"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">مقدمه: </span></span></span></strong><span dir="RTL"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">سپسیس یا عفونت جزء</span></span></span> <span dir="RTL"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">دومین</span></span></span> <span dir="RTL"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">علت</span></span></span> <span dir="RTL"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">شایع</span></span></span> <span dir="RTL"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">مرگ</span></span></span> <span dir="RTL"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">و</span></span></span> <span dir="RTL"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">میر میان بیماران </span></span></span><span dir="RTL"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">بستری</span></span></span> <span dir="RTL"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">در</span></span></span> <span dir="RTL"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">بخش</span></span></span><span dir="RTL"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;"></span></span></span><span dir="RTL"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">های</span></span></span> <span dir="RTL"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">مراقبت</span></span></span><span dir="RTL"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;"></span></span></span><span dir="RTL"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">های</span></span></span> <span dir="RTL"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">ویژه به</span></span></span> <span dir="RTL"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">شمار میرود</span></span></span><span style="font-family:Times New Roman,serif;"><span style="font-size:10.0pt;">.</span></span><span dir="RTL"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;"> با توجه به عوارض ناشی از مصرف داروهای ضدالتهابی غیراستروئیدی، استفاده از گیاهان دارویی دارای خاصیت ضدالتهابی، مانند گل محمدی برای درمان و کاهش عوارض ناشی از التهاب، توصیه میشود.</span></span></span><strong> <span dir="RTL"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">هدف: </span></span></span></strong><span dir="RTL"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">در این تحقیق </span></span></span><span dir="RTL"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">اثرات ضدالتهابی و آنتیاکسیدانی اسانس گل محمدی</span></span></span><em><span style="font-family:Times New Roman,serif;"><span style="font-size:10.0pt;">Rosa damascena </span></span></em><span style="font-family:Times New Roman,serif;"><span style="font-size:10.0pt;">Mill.</span></span><span dir="RTL"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;"> در بافت ریه رتهای سپتیکی شده در مدل تجربی التهابی </span></span></span><span style="font-family:Times New Roman,serif;"><span style="font-size:10.0pt;">CLP</span></span><span dir="RTL"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;"> مورد ارزیابی قرار گرفت. <strong>روش بررسی: </strong>موشها</span></span></span> <span dir="RTL"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">به</span></span></span> <span dir="RTL"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">پنج</span></span></span> <span dir="RTL"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">گروه</span></span></span> <span dir="RTL"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">کنترل</span></span></span> <span dir="RTL"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">منفی، کنترل مثبت و گروههای</span></span></span> <span dir="RTL"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">تیمار با</span></span></span> <span dir="RTL"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">اسانس</span></span></span> <span dir="RTL"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">گل</span></span></span> <span dir="RTL"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">محمدی</span></span></span> <span dir="RTL"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">و </span></span></span><span dir="RTL"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">ایندومتاسین تقسیم شده و 24</span></span></span> <span dir="RTL"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">ساعت</span></span></span> <span dir="RTL"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">پس</span></span></span> <span dir="RTL"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">از</span></span></span> <span dir="RTL"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">جراحی، </span></span></span><span dir="RTL"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">پارامترهای دخیل در استرس اکسیداتیو </span></span></span><span dir="RTL"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">اندازهگیری</span></span></span> <span dir="RTL"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">شدند. <strong>نتایج: </strong>سپسیس</span></span></span> <span dir="RTL"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">موجب</span></span></span> <span dir="RTL"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">کاهش</span></span></span> <span style="font-family:Times New Roman,serif;"><span style="font-size:10.0pt;">FRAP</span></span> <span dir="RTL"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">و </span></span></span><span style="font-family:Times New Roman,serif;"><span style="font-size:10.0pt;">GSH</span></span> <span dir="RTL"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">و</span></span></span> <span dir="RTL"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">افزایش</span></span></span> <span dir="RTL"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">میزان </span></span></span><span style="font-family:Times New Roman,serif;"><span style="font-size:10.0pt;">LP</span></span><span dir="RTL"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">، </span></span></span><span style="font-family:Times New Roman,serif;"><span style="font-size:10.0pt;">MPO</span></span><span dir="RTL"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">،</span></span></span> <span style="font-family:Times New Roman,serif;"><span style="font-size:10.0pt;">PGE2</span></span><span dir="RTL"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;"> و </span></span></span><span style="font-family:Times New Roman,serif;"><span style="font-size:10.0pt;">COX-2</span></span> <span dir="RTL"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">شده،</span></span></span> <span dir="RTL"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">ولی</span></span></span> <span dir="RTL"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">بر</span></span></span> <span dir="RTL"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">روی</span></span></span> <span style="font-family:Times New Roman,serif;"><span style="font-size:10.0pt;">GST</span></span><span dir="RTL"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">تأثیر معنیداری نداشت.</span></span></span> <span dir="RTL"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">اما،</span></span></span> <span dir="RTL"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">تیمار</span></span></span> <span dir="RTL"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">حیوانات</span></span></span> <span dir="RTL"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">با</span></span></span> <span dir="RTL"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">اسانس</span></span></span> <span dir="RTL"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">گل</span></span></span> <span dir="RTL"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">محمدی به صورت معنیداری در سطح</span></span></span> <span dir="RTL"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">این</span></span></span> <span dir="RTL"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">پارامترها</span></span></span><span dir="RTL"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">ی بیوشیمیایی</span></span></span> <span dir="RTL"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">مؤثر</span></span></span> <span dir="RTL"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">بوده</span></span></span> <span dir="RTL"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">است.</span></span></span> <span dir="RTL"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">همچنین،</span></span></span> <span dir="RTL"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">مطالعات</span></span></span> <span dir="RTL"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">پاتولوژی</span></span></span> <span dir="RTL"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">نشان</span></span></span> <span dir="RTL"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">میدهد</span></span></span> <span dir="RTL"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">که</span></span></span> <span dir="RTL"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">سپسیس</span></span></span> <span dir="RTL"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">منجر</span></span></span> <span dir="RTL"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">به</span></span></span> <span dir="RTL"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">ایجاد</span></span></span> <span dir="RTL"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">آسیبهایی</span></span></span> <span dir="RTL"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">در</span></span></span> <span dir="RTL"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">بافت</span></span></span> <span dir="RTL"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">ریه</span></span></span> <span dir="RTL"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">شده</span></span></span> <span dir="RTL"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">که</span></span></span> <span dir="RTL"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">این</span></span></span> <span dir="RTL"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">آسیبها</span></span></span> <span dir="RTL"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">در</span></span></span> <span dir="RTL"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">اثر</span></span></span> <span dir="RTL"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">تیمار</span></span></span> <span dir="RTL"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">با</span></span></span> <span dir="RTL"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">اسانس</span></span></span> <span dir="RTL"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">گل</span></span></span> <span dir="RTL"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">محمدی</span></span></span> <span dir="RTL"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">کاهش</span></span></span> <span dir="RTL"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">یافتهاند.</span></span></span><strong> <span dir="RTL" style="letter-spacing:-.5pt;"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">نتیجهگیری: </span></span></span></strong><span dir="RTL" style="letter-spacing:-.5pt;"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">سپسیس</span></span></span> <span dir="RTL" style="letter-spacing:-.5pt;"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">موجب</span></span></span> <span dir="RTL" style="letter-spacing:-.5pt;"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">آسیب</span></span></span> <span dir="RTL" style="letter-spacing:-.5pt;"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">اکسیداتیو</span></span></span> <span dir="RTL" style="letter-spacing:-.5pt;"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">بافت</span></span></span> <span dir="RTL" style="letter-spacing:-.5pt;"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">ریه</span></span></span> <span dir="RTL" style="letter-spacing:-.5pt;"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">شده</span></span></span> <span dir="RTL" style="letter-spacing:-.5pt;"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">و</span></span></span> <span dir="RTL" style="letter-spacing:-.5pt;"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">استفاده</span></span></span> <span dir="RTL" style="letter-spacing:-.5pt;"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">از</span></span></span> <span dir="RTL" style="letter-spacing:-.5pt;"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">اسانس</span></span></span> <span dir="RTL" style="letter-spacing:-.5pt;"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">گل</span></span></span> <span dir="RTL" style="letter-spacing:-.5pt;"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">محمدی</span></span></span> <span dir="RTL" style="letter-spacing:-.5pt;"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">میتواند</span></span></span> <span dir="RTL" style="letter-spacing:-.5pt;"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">در</span></span></span> <span dir="RTL" style="letter-spacing:-.5pt;"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">جلوگیری</span></span></span> <span dir="RTL" style="letter-spacing:-.5pt;"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">و</span></span></span> <span dir="RTL" style="letter-spacing:-.5pt;"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">بهبود</span></span></span> <span dir="RTL" style="letter-spacing:-.5pt;"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">این</span></span></span> <span dir="RTL" style="letter-spacing:-.5pt;"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">آسیبها</span></span></span> <span dir="RTL" style="letter-spacing:-.5pt;"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">مؤثر</span></span></span> <span dir="RTL" style="letter-spacing:-.5pt;"><span style="font-family:B Lotus;"><span style="font-size:11.0pt;">باشد</span></span></span><span style="letter-spacing:-.5pt;"><span style="font-family:Times New Roman,serif;"><span style="font-size:10.0pt;">.</span></span></span></div>
<strong>Background:</strong> Sepsis or infection is the second leading cause of death in people who are intensive care units. Due to the side effects of NSAIDs drugs, the use of medicinal plants with anti-inflammatory such as <em>Rosa </em>(<em>R.</em>)<em> damascene</em> Mill. for treating and reducing the symptoms of the inflammation has been suggested. <strong>Objective:</strong> The current study aimed to evaluate the anti-inflammatory and antioxodant activities of <em>Rosa (R.) damascena </em>Mill<span dir="RTL">.</span> essential oils in the lung tissue of the septic rats induced by the experimental cecal ligation and puncture (CLP) rat model. <strong>Methods:</strong> The rats were divided into 5 groups: negative control group, positive control group and treatment groups with <em>R. damascena </em>Mill. essential oils and indomethacin. After 24h of CLP surgery, the oxidative parameters were measured. <strong>Results:</strong> The induction of sepsis reduced the levels of glutathione (GSH), ferric reducing antioxidant power (FRAP) as well as increased the levels lipid peroxidation (LP), <em>myeloperoxidase</em> (MPO), <em>prostaglandin</em> E2 (PGE2) and cyclooxygenase-2 (COX-2), but it had no effects on glutathione S-transferase (GST). However, the treatments of rats with <em>R. damascena </em>Mill. essential oils have diminished the levels of biochemical parameters. Histopathological studies also demonstrated that the induction of sepsis resulted in the lung tissue damages, while these were improved by the treatment of rats with <em>R. damascena </em>Mill. essential oils. <strong>Conclusion:</strong> The oxidative damages of the lung tissue were induced by the sepsis and the administartionof <em>R. damascena </em>Mill. essential oils can be effecient in the prevention and improvement of the injuries<span dir="RTL">.</span>
اسانس گل محمدی, بافت ریه, استرس اکسیداتیو, سپسیس, CLP
Rosa damascene Mill. Essential oils, CLP, Oxidative stress, Sepsis, Lung tissue
277
294
http://jmp.ir/browse.php?a_code=A-10-929-5&slc_lang=fa&sid=1
Abolfazl
Dadkhah
ابوالفضل
دادخواه
dadkhah_bio@yahoo.com
100319475328460040879
100319475328460040879
Yes
Department of Medicine, Faculty of Medicine, Qom Branch, Islamic Azad University, Qom, Iran
گروه پزشکی، دانشکده پزشکی، واحد قم، دانشگاه آزاد اسلامی، قم، ایران
Faezeh
Fatemi
فائزه
فاطمی
fatemi81@yahoo.com
100319475328460040880
100319475328460040880
No
Materials and Nuclear Fuel Research School, Nuclear Science and Technology Research Institute, Tehran, Iran
پژوهشکده مواد و سوخت هسته ای، پژوهشگاه علوم و فنون هسته ای، تهران، ایران
Mohammad Reza
Mohammadi Malayeri
محمدرضا
محمدی ملایری
Dr.malayeri@yahoo.com
100319475328460040881
100319475328460040881
No
Department of Pathobiology, Faculty of Veterinary Medicine, Garmsar Branch, Islamic Azad University, Garmsar, Iran
گروه پاتوبیولوژی، دانشکده دامپزشکی،دانشگاه آزاد اسلامی، واحدگرمسار،گرمسار، ایران
Mohammad Hassan
Karvin Ashtiani
محمدحسن
کاروین آشتیانی
salomedini@yahoo.com
100319475328460040882
100319475328460040882
No
Department of biology, Faculty of Sciences, Hakim Sabzevari University, Sabzevar, Iran
دانشکده علوم پایه، دانشگاه حکیم سبزواری، سبزوار، ایران
Zahra
Mosavi
زهرا
موسوی
salomedini@yahoo.com
100319475328460040883
100319475328460040883
No
Department of Biochemistry, Faculty of Sciences, Payame-e-Noor University, Tehran, Iran
دانشکده علوم پایه، دانشگاه آزاد اسلامی، واحد قم، قم، ایران
Sabere
Naij
صابره
ناییج
sabere.naij.66@gmail.com
100319475328460040884
100319475328460040884
No
Faculty of Botany, Payam Noor University, Tehran, Iran
گروه گیاه شناسی، دانشگاه پیام نور، تهران، ایران
Salome
Dini
سالومه
دینی
salomehdini6@gmail.com
100319475328460040885
100319475328460040885
No
Young Researchers and Elite Club, Karaj Branch, Islamic Azad University, Karaj, Iran
باشگاه پژوهشگران و نخبگان جوان، دانشگاه آزاد اسلامی واحد کرج، کرج، ایران