fa Lipid Peroxidation Inhibition, Superoxide Anion and Nitric Oxide Radical Scavenging Properties of <i>Thymus daenensis</i> and <i>Anethum graveolens</i> Essential Oils فارماكوگنوزی و فارماسيوتيكس Pharmacognosy & Pharmaceutics مروری Review <div dir="ltr" style="text-align: justify;"><strong>Background:</strong> Safety and efficacy of the synthetic antioxidants used in the food industry are frequently questioned because such antioxidants are unstable and highly volatile, therefore, interest in finding naturally occurring antioxidants that have the potential to protect human beings from damage induced by oxidative stress has intensified. <strong>Objective:</strong> Bioactivities of <em>Thymus daenensis</em> and <em>Anethum graveolens</em> essential oils with special reference to their antioxidative properties are studied. <strong>Methods:</strong> Total phenolic content (TPC), lipid peroxidation inhibition (LPI), ferrous-ion chelating (FIC), superoxide anion and nitric oxide radical scavenging, and tyrosinase inhibition activities of the essential oils were determined. <strong>Results: </strong>TPC of <em>T. daenensis</em> and <em>A. graveolens</em> oils were 644.07&plusmn;6.79 and 174.91&plusmn;2.05 mg GAE/100 g. <em>T. daenensis</em> and <em>A. graveolens</em> oils showed the highest LPI activity with FICs of 63.28&plusmn;0.21 and 70.22&plusmn;1.9 percent respectively. Superoxide anion and nitric oxide radical scavenging activities of the above oils had IC50 of 0.013, 0.001 and 0.005, 0.0014 mg, respectively. <em>A. graveolens</em> oil showed 6 fold higher anti - tyrosinase activity than <em>T. daenensis</em> oil. <strong>Conclusion:</strong> There was not correlation between lipid peroxidation or ferrous ion chelating activities with total phenolics implying that the oils contain chelating ligands. The effects of antioxidant phytochemicals in the biological systems are ascribed on their ability to scavenge radicals, chelating metals, activate the antioxidant enzymes, and to inhibit the oxidases. <em>T. daenensis</em> and <em>A. graveolens</em> oils have good commercial potential in both food processing and cosmetic industries.</div> <div dir="ltr" style="text-align: justify;"><strong>Background:</strong> Safety and efficacy of the synthetic antioxidants used in the food industry are frequently questioned because such antioxidants are unstable and highly volatile, therefore, interest in finding naturally occurring antioxidants that have the potential to protect human beings from damage induced by oxidative stress has intensified. <strong>Objective:</strong> Bioactivities of <em>Thymus daenensis</em> and <em>Anethum graveolens</em> essential oils with special reference to their antioxidative properties are studied. <strong>Methods:</strong> Total phenolic content (TPC), lipid peroxidation inhibition (LPI), ferrous-ion chelating (FIC), superoxide anion and nitric oxide radical scavenging, and tyrosinase inhibition activities of the essential oils were determined. <strong>Results: </strong>TPC of <em>T. daenensis</em> and <em>A. graveolens</em> oils were 644.07&plusmn;6.79 and 174.91&plusmn;2.05 mg GAE/100 g. <em>T. daenensis</em> and <em>A. graveolens</em> oils showed the highest LPI activity with FICs of 63.28&plusmn;0.21 and 70.22&plusmn;1.9 percent respectively. Superoxide anion and nitric oxide radical scavenging activities of the above oils had IC50 of 0.013, 0.001 and 0.005, 0.0014 mg, respectively. <em>A. graveolens</em> oil showed 6 fold higher anti - tyrosinase activity than <em>T. daenensis</em> oil. <strong>Conclusion:</strong> There was not correlation between lipid peroxidation or ferrous ion chelating activities with total phenolics implying that the oils contain chelating ligands. The effects of antioxidant phytochemicals in the biological systems are ascribed on their ability to scavenge radicals, chelating metals, activate the antioxidant enzymes, and to inhibit the oxidases. <em>T. daenensis</em> and <em>A. graveolens</em> oils have good commercial potential in both food processing and cosmetic industries.</div> Lipid peroxidation, Superoxide, Nitric oxide, Radical scavenging, <,i>,Thymus daenensis<,/i>,, <,i>,Anethum graveolens<,/i>,, Essential oils Lipid peroxidation, Superoxide, Nitric oxide, Radical scavenging, <,i>,Thymus daenensis<,/i>,, <,i>,Anethum graveolens<,/i>,, Essential oils 109 120 http://jmp.ir/browse.php?a_code=A-10-179-1&slc_lang=fa&sid=1 M Dadashpour M Dadashpour 100319475328460037644 100319475328460037644 No Department of Biotechnology, College of Basic Sciences, Shahed University Department of Biotechnology, College of Basic Sciences, Shahed University I Rasooli I Rasooli rasooli@shahed.ac.ir 100319475328460037645 100319475328460037645 Yes Medicinal Plants Research Center and Department of Biology, Shahed University Medicinal Plants Research Center and Department of Biology, Shahed University F Sefidkon F Sefidkon 100319475328460037646 100319475328460037646 No Department of Medicinal Plants, Research Institute of Forests and Rangelands Department of Medicinal Plants, Research Institute of Forests and Rangelands MB Rezaei MB Rezaei 100319475328460037647 100319475328460037647 No Department of Microbiology, College of Basic Sciences, Shahed University Department of Microbiology, College of Basic Sciences, Shahed University S Darvish Alipour Astaneh S Darvish Alipour Astaneh 100319475328460037648 100319475328460037648 No Department of Microbiology, College of Basic Sciences, Shahed University, Tehran-Iran Department of Microbiology, College of Basic Sciences, Shahed University, Tehran-Iran