fa Antioxidant Effect of <i>Lycopersicum esculentum</i> on Plasma Superoxide Dismutase, Catalase and Malondialdehyde in Rat Espoused with Lead Acetate فارماكولوژی و سم شناسی Pharmacology & Toxicology مروری Review <div dir="ltr" style="text-align: justify;"><strong>Background:</strong> Lead, an example of heavy metals, has, for decades, being known for its adverse effects on various body organs and systems such that their functions are compromised. <strong>Objective:</strong> In the present study, the ability of <em>Lycopersicum esculentum</em> on decrease toxic effects of lead acetate on plasma superoxide dismutase, catalase and malondialdehyde in Rat. Lead to adversely affect the Liver tissue apoptosis was investigated and <em>Lycopersicum esculentum</em>: Source of antioxidants was administered orally to prevent the adverse effects of Pb. <strong>Methods:</strong> Eighteen wistar rats, randomized into three groups (n = 6), were used for this study. Animals in Group A served as the control and was drinking distilled water. Animals in Groups B and C were drinking 1% Lead acetate (LA). Group C animals were, in addition to drinking LA, treated with 1.5 ml of <em>Lycopersicum esculentum</em> /day. All treatments were for 10 weeks. <strong>Results:</strong> The obtained results showed that Pb caused a significant reduction in the liver weight, plasma and tissue superoxide dismutase and catalase activity, but a significant increase in plasma malondialdehyde concentration. <strong>Conclusion:</strong> These findings lead to the conclusion that <em>Lycopersicum esculentum</em> significantly lowered the adverse effects of Pb oxidative stress.</div> <div dir="ltr" style="text-align: justify;"><strong>Background:</strong> Lead, an example of heavy metals, has, for decades, being known for its adverse effects on various body organs and systems such that their functions are compromised. <strong>Objective:</strong> In the present study, the ability of <em>Lycopersicum esculentum</em> on decrease toxic effects of lead acetate on plasma superoxide dismutase, catalase and malondialdehyde in Rat. Lead to adversely affect the Liver tissue apoptosis was investigated and <em>Lycopersicum esculentum</em>: Source of antioxidants was administered orally to prevent the adverse effects of Pb. <strong>Methods:</strong> Eighteen wistar rats, randomized into three groups (n = 6), were used for this study. Animals in Group A served as the control and was drinking distilled water. Animals in Groups B and C were drinking 1% Lead acetate (LA). Group C animals were, in addition to drinking LA, treated with 1.5 ml of <em>Lycopersicum esculentum</em> /day. All treatments were for 10 weeks. <strong>Results:</strong> The obtained results showed that Pb caused a significant reduction in the liver weight, plasma and tissue superoxide dismutase and catalase activity, but a significant increase in plasma malondialdehyde concentration. <strong>Conclusion:</strong> These findings lead to the conclusion that <em>Lycopersicum esculentum</em> significantly lowered the adverse effects of Pb oxidative stress.</div> Antioxidant, Lead acetate, <,i>,Lycopersicum esculentum<,/i>,, Reactive oxygen species Antioxidant, Lead acetate, <,i>,Lycopersicum esculentum<,/i>,, Reactive oxygen species 48 53 http://jmp.ir/browse.php?a_code=A-10-175-2&slc_lang=fa&sid=1 A Khaki A Khaki arashkhaki@yahoo.com 100319475328460037624 100319475328460037624 Yes Department of Veterinary Pathology, Islamic Azad University Tabriz Branch Department of Veterinary Pathology, Islamic Azad University Tabriz Branch