fa Anti-inflammatory Effect of <i>Thymus kotschyanus</i> Boiss. & Hohen. Extract on Rat’s Hind Paw Edema Induced by Carrageenan فارماكولوژی و سم شناسی Pharmacology & Toxicology پژوهشی Research <div dir="ltr" style="text-align: justify;"><strong>Background:</strong> Advantages of herbal drugs have been known to human being for many years and they have been used for treatment of many diseases. Nowadays, inflammation is known to be one of the basic pathologic causes of the diseases. <strong>Objective:</strong> In this study the anti-inflammatory effect of <em>Thymus kotschyanus</em> Boiss & Hohen was investigated. <strong>Methods: </strong>Forty two Wistar rats were used in three divided groups. In the first group, extract of <em>Thymus kotschyanus</em> Boiss & Hohen in doses of 50, 100, 150, 200 mg/kg was injected intra peritoneal and after one hour they were treated with hind paw edema test with carrageenan. In the second group, Indomethacin with the dose of 5 mg/kg was injected one hour before carrageenan and in the third one, saline was injected before carrageenan, every hours after carrageenan injection to rat&rsquo;s right hind paw the inflammation was separately measured by the change in the volume of mercury (plethysmometer). <strong>Results: </strong>Indomethacin and <em>Thymus kotschyanus </em>Boiss & Hohen extract had significantly reduced edema in all five measurements (p<0.001). There was no significant difference between Indometacin and the extract in reducing edema in the first to fourth hour, but in the fifth hour, the herbal drug showed a significant difference of anti-inflammatory effect with Indometacin in all doses (p<0.05). <strong>Conclusion:</strong> The methanolic extract of <em>Thymus kotschyanus</em> Boiss & Hohen has anti- inflammatory effect in all doses which is dose dependant and can be used instead of or as a synergist for Indometacin. Higher doses of herbal extract may have more anti-inflammatory effects.</div> <div dir="ltr" style="text-align: justify;"><strong>Background:</strong> Advantages of herbal drugs have been known to human being for many years and they have been used for treatment of many diseases. Nowadays, inflammation is known to be one of the basic pathologic causes of the diseases. <strong>Objective:</strong> In this study the anti-inflammatory effect of <em>Thymus kotschyanus</em> Boiss & Hohen was investigated. <strong>Methods: </strong>Forty two Wistar rats were used in three divided groups. In the first group, extract of <em>Thymus kotschyanus</em> Boiss & Hohen in doses of 50, 100, 150, 200 mg/kg was injected intra peritoneal and after one hour they were treated with hind paw edema test with carrageenan. In the second group, Indomethacin with the dose of 5 mg/kg was injected one hour before carrageenan and in the third one, saline was injected before carrageenan, every hours after carrageenan injection to rat&rsquo;s right hind paw the inflammation was separately measured by the change in the volume of mercury (plethysmometer). <strong>Results: </strong>Indomethacin and <em>Thymus kotschyanus </em>Boiss & Hohen extract had significantly reduced edema in all five measurements (p<0.001). There was no significant difference between Indometacin and the extract in reducing edema in the first to fourth hour, but in the fifth hour, the herbal drug showed a significant difference of anti-inflammatory effect with Indometacin in all doses (p<0.05). <strong>Conclusion:</strong> The methanolic extract of <em>Thymus kotschyanus</em> Boiss & Hohen has anti- inflammatory effect in all doses which is dose dependant and can be used instead of or as a synergist for Indometacin. Higher doses of herbal extract may have more anti-inflammatory effects.</div> Anti-inflammatory agent, <,i>,Thymus kotschyanus<,/i>, Boiss &,, Hohen, Hind paw edema test, Carrageenan Anti-inflammatory agent, <,i>,Thymus kotschyanus<,/i>, Boiss &,, Hohen, Hind paw edema test, Carrageenan 25 32 http://jmp.ir/browse.php?a_code=A-10-149-2&slc_lang=fa&sid=1 A Bakhtiarian A Bakhtiarian 100319475328460037606 100319475328460037606 No Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences F Aarabi Moghaddam F Aarabi Moghaddam 100319475328460037607 100319475328460037607 No Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences MM Zamani MM Zamani 100319475328460037608 100319475328460037608 No Scientific Students’ Research Center, Tehran University of Medical Sciences Scientific Students’ Research Center, Tehran University of Medical Sciences SG Ghamami SG Ghamami 100319475328460037609 100319475328460037609 No Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences B Farahanikia B Farahanikia 100319475328460037610 100319475328460037610 No Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences M Khanavi M Khanavi khanavim@tums.ac.ir 100319475328460037611 100319475328460037611 Yes Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences