en Antidiabetic Activity of Aqueous Fruit Extract of <i>Ribes biebersteinii</i> in Streptozotocin Induced Diabetic Rats فارماكولوژی و سم شناسی Pharmacology & Toxicology پژوهشی Research <div dir="ltr" style="text-align: justify;"><strong>Background:</strong> <em>Ribes biebersteinii (Rb) </em>is one of pharmaceutical plants which was used in traditional medicine for decreasing blood sugar.<br> <strong>Objective:</strong> In this study, effect of aqueous fruit extract of <em>Rb </em>on blood sugar of rats was investigated.<br> <strong>Methods:</strong> In this research 60 male Wistar rats were categorized randomly in 10 equal groups with two timeframes (7 & 14 days). Extraction of Rb was performed with 50 g in 500 ml of distilled water for 18 hours by using a soxhlet extractor. For inducing diabetes, streptozotocin<br> 7 mg/0.5 ml in normal saline was injected intramuscularly per 100 gram of rat body weight. Aqueous fruit extract of <em>Rb </em>was given orally to rats daily (80 mg/0.5 ml in distilled water per 100 gram of rat body weight). Then the blood samples sent to the laboratory to measure the following factors: glucose, lipids; and activity of the enzymes in plasma serum.<br> <strong>Results:</strong> <em>Ribes biebersteinii </em>compared to diabetic group had significant effect on blood sugar (P&le;0.0001). After 14 days, there is significant difference between weight of treated rats with fruit extract of <em>Rb</em> (162.2 <span dir="RTL">&plusmn;</span> 1.70) and diabetic group (149.7<span dir="RTL">&plusmn;</span>2.16) (P&le;0.001). Also fruit extract of <em>Rb </em>had no effect on blood fat (Cholesterol, Triglyceride, LDL, HDL) of treated rats.<br> <strong>Conclusion:</strong> According to the results concluded that extract of <em>Ribes biebersteinii</em> had effect on the blood sugar of rats and led to decrease blood sugar of rats. Because the fruit is rich in anthocyanins, this effect may be due to the its antioxidant effect.<br> &nbsp;</div> <div dir="ltr" style="text-align: justify;"><strong>Background:</strong> <em>Ribes biebersteinii (Rb) </em>is one of pharmaceutical plants which was used in traditional medicine for decreasing blood sugar.<br> <strong>Objective:</strong> In this study, effect of aqueous fruit extract of <em>Rb </em>on blood sugar of rats was investigated.<br> <strong>Methods:</strong> In this research 60 male Wistar rats were categorized randomly in 10 equal groups with two timeframes (7 & 14 days). Extraction of Rb was performed with 50 g in 500 ml of distilled water for 18 hours by using a soxhlet extractor. For inducing diabetes, streptozotocin<br> 7 mg/0.5 ml in normal saline was injected intramuscularly per 100 gram of rat body weight. Aqueous fruit extract of <em>Rb </em>was given orally to rats daily (80 mg/0.5 ml in distilled water per 100 gram of rat body weight). Then the blood samples sent to the laboratory to measure the following factors: glucose, lipids; and activity of the enzymes in plasma serum.<br> <strong>Results:</strong> <em>Ribes biebersteinii </em>compared to diabetic group had significant effect on blood sugar (P&le;0.0001). After 14 days, there is significant difference between weight of treated rats with fruit extract of <em>Rb</em> (162.2 <span dir="RTL">&plusmn;</span> 1.70) and diabetic group (149.7<span dir="RTL">&plusmn;</span>2.16) (P&le;0.001). Also fruit extract of <em>Rb </em>had no effect on blood fat (Cholesterol, Triglyceride, LDL, HDL) of treated rats.<br> <strong>Conclusion:</strong> According to the results concluded that extract of <em>Ribes biebersteinii</em> had effect on the blood sugar of rats and led to decrease blood sugar of rats. Because the fruit is rich in anthocyanins, this effect may be due to the its antioxidant effect.<br> &nbsp;</div> Ribes biebersteinii, Diabetes, Rat, Streptozotocin Ribes biebersteinii, Diabetes, Rat, Streptozotocin 77 90 http://jmp.ir/browse.php?a_code=A-10-1552-4&slc_lang=en&sid=1 SM Ahmadi SM Ahmadi ahmadi.marzie63@gmail.com 100319475328460041169 100319475328460041169 No Pharmacy Student of Ramsar, Mazandaran University of Medical Science, Ramsar, Iran Pharmacy Student of Ramsar, Mazandaran University of Medical Science, Ramsar, Iran M Azadbakht M Azadbakht atiehahmadi2@gmail.com 100319475328460041170 100319475328460041170 Yes Department of Pharmacology, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran Department of Pharmacognosy, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran N Ahangar N Ahangar dr.n.ahangar@gmail.com 100319475328460041171 100319475328460041171 No Department of Toxicology & Pharmacology, Faculty of Pharmacy, Mazandaran University of Medical Science, Sari, Iran Department of Toxicology & Pharmacology, Faculty of Pharmacy, Mazandaran University of Medical Science, Sari, Iran