fa Blood Glucose Lowering Effects of <i>Nigella sativa</i> L. Seeds Oil in Healthy Volunteers: a Randomized, Double-Blind, Placebo-Controlled Clinical Trial فارماكولوژی و سم شناسی Pharmacology & Toxicology پژوهشی Research <div dir="ltr" style="text-align: justify;"><strong>Background:</strong> Several formulations of the <em>Nigella sativa</em> L. seeds (Black seed) have been used in traditional medicine for treatment and prevention of a wide range of diseases including diabetes. But blood glucose lowering effects of its oil in a clinical study is of an interest. <strong>Objective:</strong> The present study was undertaken to explore the possible blood glucose lowering effects of the Black seed oil on healthy subjects. <strong>Methods:</strong> A randomized clinical trial was conducted in 70 healthy subjects referring to Bagiatallah hospital. The subjects were randomly selected and enrolled in to two groups of 35 each. One group received 2.5 ml Black seed oil and the other group received similarly 2.5 ml mineral oil two times a day. The fasting blood glucose, HbA1c, liver and renal function test was determined at the baseline and after two months. <strong>Results:</strong> Results showed that significant decrease in fasting blood glucose and HbA1c levels in Black seed oil treated patients as compared to control group at the end of the study. No notable liver, kidney and gastrointestinal side effects were observed in these two groups. <strong>Conclusion:</strong> Administration of 5 ml Black seed oil daily to healthy subjects for two months had beneficial effects on improving glycemic profile without any adverse effects.</div> <div dir="ltr" style="text-align: justify;"><strong>Background:</strong> Several formulations of the <em>Nigella sativa</em> L. seeds (Black seed) have been used in traditional medicine for treatment and prevention of a wide range of diseases including diabetes. But blood glucose lowering effects of its oil in a clinical study is of an interest. <strong>Objective:</strong> The present study was undertaken to explore the possible blood glucose lowering effects of the Black seed oil on healthy subjects. <strong>Methods:</strong> A randomized clinical trial was conducted in 70 healthy subjects referring to Bagiatallah hospital. The subjects were randomly selected and enrolled in to two groups of 35 each. One group received 2.5 ml Black seed oil and the other group received similarly 2.5 ml mineral oil two times a day. The fasting blood glucose, HbA1c, liver and renal function test was determined at the baseline and after two months. <strong>Results:</strong> Results showed that significant decrease in fasting blood glucose and HbA1c levels in Black seed oil treated patients as compared to control group at the end of the study. No notable liver, kidney and gastrointestinal side effects were observed in these two groups. <strong>Conclusion:</strong> Administration of 5 ml Black seed oil daily to healthy subjects for two months had beneficial effects on improving glycemic profile without any adverse effects.</div> Nigella sativa, Black seed oil, Blood glucose, Traditional medicine Nigella sativa, Black seed oil, Blood glucose, Traditional medicine 90 94 http://jmp.ir/browse.php?a_code=A-10-90-3&slc_lang=fa&sid=1 R Mohtashami R Mohtashami 100319475328460037506 100319475328460037506 No Religion and Medicine Research Center, Baqiyatallah University of Medical Sciences Religion and Medicine Research Center, Baqiyatallah University of Medical Sciences M Amini M Amini 100319475328460037507 100319475328460037507 No Gastroentrology and Liver diseases Research Center, Baqiyatallah University of Medical Sciences Gastroentrology and Liver diseases Research Center, Baqiyatallah University of Medical Sciences H Fallah Huseini H Fallah Huseini huseini_fallah@yahoo.com 100319475328460037508 100319475328460037508 Yes Department of Pharmacology, Institute of Medicinal Plants, ACECR Department of Pharmacology, Institute of Medicinal Plants, ACECR M Ghamarchehre M Ghamarchehre 100319475328460037509 100319475328460037509 No Gastroentrology and Liver diseases Research Center, Baqiyatallah University of Medical Sciences Gastroentrology and Liver diseases Research Center, Baqiyatallah University of Medical Sciences Z Sadeqhi Z Sadeqhi 100319475328460037510 100319475328460037510 No Human Resource & Management Development Deputy, Presidential Organization Human Resource & Management Development Deputy, Presidential Organization R Hajiagaee R Hajiagaee 100319475328460037511 100319475328460037511 No Department of Pharmacology, Institute of Medicinal Plants, ACECR Department of Pharmacology, Institute of Medicinal Plants, ACECR A Fallah Huseini A Fallah Huseini 100319475328460037512 100319475328460037512 No Shahed Medical College Tehran Shahed Medical College Tehran