fa <i>Ginkgo biloba</i> for Improvement of Memory and Quality of Life in Multiple Sclerosis: an Open Trial فارماكولوژی و سم شناسی Pharmacology & Toxicology پژوهشی Research <div dir="ltr" style="text-align: justify;"><strong>Background:</strong> Multiple sclerosis (MS) is a chronic demyelinating disease that can affect cognitive function. The purpose of this study was to assess the efficacy of <em>Ginkgo biloba</em> (GB) on improvement of memory impairment and quality of life in patients with MS. <strong>Methods:</strong> This study was an 8-week, open study of patients with MS. Thirty patients was recruited from a variety of outpatient settings. All participants met McDonald&#39;s diagnostic criteria for MS and had Wechsler score of<80. All subjects received Ginkgo 240 mg/day, TDS except one that received 120 mg/day, TDS due to history of gastritis Participants were assessed by Wechsler memory scale, MSIS-29 test and Beck Depression Inventory (BDI) which measure memory, quality of life and depression respectively at baseline and after 8 weeks of treatment. <strong>Results:</strong> Administration of Ginkgo significantly improved Wechsler and MSIS-29 scores. Subjects who were less impaired at baseline on the Wechsler test experienced more improvement with GB. <strong>Conclusion:</strong> The present study indicates <em>Ginkgo biloba</em> as a very well tolerated medication for improvement of cognitive impairments in people suffering from MS.</div> <div dir="ltr" style="text-align: justify;"><strong>Background:</strong> Multiple sclerosis (MS) is a chronic demyelinating disease that can affect cognitive function. The purpose of this study was to assess the efficacy of <em>Ginkgo biloba</em> (GB) on improvement of memory impairment and quality of life in patients with MS. <strong>Methods:</strong> This study was an 8-week, open study of patients with MS. Thirty patients was recruited from a variety of outpatient settings. All participants met McDonald&#39;s diagnostic criteria for MS and had Wechsler score of<80. All subjects received Ginkgo 240 mg/day, TDS except one that received 120 mg/day, TDS due to history of gastritis Participants were assessed by Wechsler memory scale, MSIS-29 test and Beck Depression Inventory (BDI) which measure memory, quality of life and depression respectively at baseline and after 8 weeks of treatment. <strong>Results:</strong> Administration of Ginkgo significantly improved Wechsler and MSIS-29 scores. Subjects who were less impaired at baseline on the Wechsler test experienced more improvement with GB. <strong>Conclusion:</strong> The present study indicates <em>Ginkgo biloba</em> as a very well tolerated medication for improvement of cognitive impairments in people suffering from MS.</div> Ginkgo biloba, Multiple Sclerosis, Memory impairment, Wechsler test Ginkgo biloba, Multiple Sclerosis, Memory impairment, Wechsler test 33 42 http://jmp.ir/browse.php?a_code=A-10-34-10&slc_lang=fa&sid=1 M Noroozian M Noroozian 100319475328460037478 100319475328460037478 No Psychiatric Research Center, Roozbeh Psychiatric Hospital, Tehran University of Medical Sciences Psychiatric Research Center, Roozbeh Psychiatric Hospital, Tehran University of Medical Sciences S Mohebbi-Rasa S Mohebbi-Rasa 100319475328460037479 100319475328460037479 No Psychiatric Research Center, Roozbeh Psychiatric Hospital, Tehran University of Medical Sciences Psychiatric Research Center, Roozbeh Psychiatric Hospital, Tehran University of Medical Sciences AK Tasviechi AK Tasviechi 100319475328460037480 100319475328460037480 No Psychiatric Research Center, Roozbeh Psychiatric Hospital, Tehran University of Medical Sciences Psychiatric Research Center, Roozbeh Psychiatric Hospital, Tehran University of Medical Sciences MA Sahraian MA Sahraian 100319475328460037481 100319475328460037481 No Sina Hospital, Tehran University of Medical Sciences Sina Hospital, Tehran University of Medical Sciences N Karamghadiri N Karamghadiri 100319475328460037482 100319475328460037482 No Psychiatric Research Center, Roozbeh Psychiatric Hospital, Tehran University of Medical Sciences Psychiatric Research Center, Roozbeh Psychiatric Hospital, Tehran University of Medical Sciences S Akhondzadeh S Akhondzadeh s.akhond@neda.net 100319475328460037483 100319475328460037483 Yes Psychiatric Research Center, Roozbeh Psychiatric Hospital, Tehran University of Medical Sciences Psychiatric Research Center, Roozbeh Psychiatric Hospital, Tehran University of Medical Sciences