Journal of Medicinal Plants

en Pergularia tomentosa, from Traditional Uses to Ecology and Phytochemistry Pergularia tomentosa, from Traditional Uses to Ecology and Phytochemistry فارماكوگنوزی و فارماسيوتيكس Pharmacognosy & Pharmaceutics تحقیقاتی کوتاه Short Communication <div dir="ltr" style="text-align: justify;">Background: Pergularia tomentosa L. has several traditional uses and biological activities which need to be more investigated. Objective: In this study, some ecological and phytochemical properties of Pergularia tomentosa were assessed. The flavonoids and cardenolides in the aqueous extract of leaves were identified with LCMS techniques. Methods: Some quantity characteristics of P. tomentosa were measured. Extraction was performed according to the traditional method (aqueous extract at room temperature). Metabolite profiling was conducted using untargeted liquid chromatography coupled to high resolution mass spectrometry (LCeESI-OrbitrapeMS). Data were analyzed by Xcalibur version 2.1. Results: Results showed that length of roots, leaves and fruits and the height of aerial parts were 23-30 cm, 2.5-3.2 cm, 4.9- 5.4 cm and 40-58.00 cm, respectively. Physiography and canopy cover were two important variables on these properties. We also identified 19 natural products in aqueous extract, 15 phenolics and flavonoids and 4 cardenolides. Three flavonoids (8, 11 and 14) and one cardenolide (17) had been previously isolated in P. tomentosa and 3 cardenolides (5, 18 and 19) has been reported for the first time in this plant. Conclusion: Results indicated that the leaves of P. tomentosa are a rich source of flavonoids and cardenolides. These findings suggest that leaves of this plant can be a good source of natural antioxidant and antitumor compounds. However, this plant needs special conservational efforts. Therefore, planting this plant under the canopy or along the borders of waterways can help in an appropriate habitat for its conservation and reclamation.  </div> <div dir="ltr" style="text-align: justify;">Background: Pergularia tomentosa L. has several traditional uses and biological activities which need to be more investigated. Objective: In this study, some ecological and phytochemical properties of Pergularia tomentosa were assessed. The flavonoids and cardenolides in the aqueous extract of leaves were identified with LCMS techniques. Methods: Some quantity characteristics of P. tomentosa were measured. Extraction was performed according to the traditional method (aqueous extract at room temperature). Metabolite profiling was conducted using untargeted liquid chromatography coupled to high resolution mass spectrometry (LCeESI-OrbitrapeMS). Data were analyzed by Xcalibur version 2.1. Results: Results showed that length of roots, leaves and fruits and the height of aerial parts were 23-30 cm, 2.5-3.2 cm, 4.9- 5.4 cm and 40-58.00 cm, respectively. Physiography and canopy cover were two important variables on these properties. We also identified 19 natural products in aqueous extract, 15 phenolics and flavonoids and 4 cardenolides. Three flavonoids (8, 11 and 14) and one cardenolide (17) had been previously isolated in P. tomentosa and 3 cardenolides (5, 18 and 19) has been reported for the first time in this plant. Conclusion: Results indicated that the leaves of P. tomentosa are a rich source of flavonoids and cardenolides. These findings suggest that leaves of this plant can be a good source of natural antioxidant and antitumor compounds. However, this plant needs special conservational efforts. Therefore, planting this plant under the canopy or along the borders of waterways can help in an appropriate habitat for its conservation and reclamation.  </div> ,P. tomentosa, Cardenolide, Flavonoid, LC-ESI-Orbitrap-MS/MS, Quantity characteristics P. tomentosa, Cardenolide, Flavonoid, LC-ESI-Orbitrap-MS/MS, Quantity characteristics 108 118 http://jmp.ir/browse.php?a_code=A-10-1536-1&slc_lang=en&sid=1 SH Hosseini Kahnouj سیدحمزه حسینی کهنوج shhosseinik@ut.ac.ir 100319475328460041324 100319475328460041324 No Department of Reclamation of Arid Mountainous Regions, Natural Resources Faculty, University of Tehra Department of Reclamation of Arid and Mountainous Regions, Natural Resources Faculty, University of Tehran, Iran M Ayyari مهدی عیاری m.ayyari@modares.ac.ir 100319475328460041325 100319475328460041325 No Department of Horticultural Science, Tarbiat Modares University (TMU), Tehran, Iran Department of Horticultural Science, Tarbiat Modares University (TMU), Tehran, Iran Hossein Azarnivand حسین آذرنیوند hazar@ut.ac.ir 100319475328460041326 100319475328460041326 Yes Department of Reclamation of Arid Mountainous Regions, Natural Resources Faculty, University of Tehran, Iran Department of Reclamation of Arid Mountainous Regions, Natural Resources Faculty, University of Tehran, Iran S Piacente سونیا پیاسنت piacenteae@unisa.it 100319475328460041327 100319475328460041327 No 4Department of Farmacy, University of Salerno, Italy Department of Pharmacy, University of Salerno, Italy MA Zare Chahouki محمدعلی زارع چاهوکی mazar@ut.aciir 100319475328460041328 100319475328460041328 No Department of Reclamation of Arid Mountainous Regions, Natural Resources Faculty, University of Tehran, Iran Department of Reclamation of Arid Mountainous Regions, Natural Resources Faculty, University of Tehran, Iran