en Hazel (<i>Corylus avellana</i> L.) as a New Source of Taxol and Taxanes فارماكوگنوزی و فارماسيوتيكس Pharmacognosy & Pharmaceutics پژوهشی Research <div dir="ltr" style="text-align: justify;">Taxol is used to treatment of variety cancers including ovarian, breast, lung, head and neck carcinomas and the AIDS-related Karposi&rsquo;s carcinoma, and was originally obtained from bark of <em>taxus brevifolia</em>. However the amount of extracted taxol from taxus is extremely low and cannot be considered as a suitable commercial source and it has led to studies for finding new sources of <em>Taxol</em>. In 1998, Angela Hoffman and her team reported that hazel could be as a taxol-producing species and it has been confirmed by recent studies. On the other hand, the genes and enzymes involved in taxol biosynthesis pathway in <em>taxus</em> sp. have been identified and characterized but because of very slow growth and difficult somatic embryogenesis, manipulation of taxus is restricted. Instead, hazel with widely contribution in the world, easy invitro culture and characterization of some genes involved in the pathways of MVA and DXP (such as HMGR, IPI and GGPP), makes possibility of manipulation of taxol biosynthesis pathway. In this paper we reviewed a summary of genetic and biotechnology studies on hazel.</div> <div dir="ltr" style="text-align: justify;">Taxol is used to treatment of variety cancers including ovarian, breast, lung, head and neck carcinomas and the AIDS-related Karposi&rsquo;s carcinoma, and was originally obtained from bark of <em>taxus brevifolia</em>. However the amount of extracted taxol from taxus is extremely low and cannot be considered as a suitable commercial source and it has led to studies for finding new sources of <em>Taxol</em>. In 1998, Angela Hoffman and her team reported that hazel could be as a taxol-producing species and it has been confirmed by recent studies. On the other hand, the genes and enzymes involved in taxol biosynthesis pathway in <em>taxus</em> sp. have been identified and characterized but because of very slow growth and difficult somatic embryogenesis, manipulation of taxus is restricted. Instead, hazel with widely contribution in the world, easy invitro culture and characterization of some genes involved in the pathways of MVA and DXP (such as HMGR, IPI and GGPP), makes possibility of manipulation of taxol biosynthesis pathway. In this paper we reviewed a summary of genetic and biotechnology studies on hazel.</div> Taxol, Hazel, MVA pathway, DXP or MEP pathway Taxol, Hazel, MVA pathway, DXP or MEP pathway 66 77 http://jmp.ir/browse.php?a_code=A-10-59-7&slc_lang=en&sid=1 A Qaderi A Qaderi 100319475328460037148 100319475328460037148 No Department of Biotechnology of Medicinal Plants, Institute of Medicinal Plants, ACECR, Karaj, Iran Department of Biotechnology of Medicinal Plants, Institute of Medicinal Plants, ACECR, Karaj, Iran M Omidi M Omidi 100319475328460037149 100319475328460037149 No Department of Agronomy and Plant Breeding, Faculty of Agriculture, Tehran University, Tehran, Iran Department of Agronomy and Plant Breeding, Faculty of Agriculture, Tehran University, Tehran, Iran A Etminan A Etminan 100319475328460037150 100319475328460037150 No Department of Plant Breeding, Kermanshah Branch, Islamic Azad University, Kermanshah, Iran Department of Plant Breeding, Kermanshah Branch, Islamic Azad University, Kermanshah, Iran A Oladzad A Oladzad 100319475328460037151 100319475328460037151 No Department of Biotechnology of Medicinal Plants, Institute of Medicinal Plants, ACECR, Karaj, Iran Department of Biotechnology of Medicinal Plants, Institute of Medicinal Plants, ACECR, Karaj, Iran C Ebrahimi C Ebrahimi 100319475328460037152 100319475328460037152 No Department of Biotechnology of Medicinal Plants, Institute of Medicinal Plants, ACECR, Karaj, Iran Department of Biotechnology of Medicinal Plants, Institute of Medicinal Plants, ACECR, Karaj, Iran MR Dehghani Mashkani MR Dehghani Mashkani 100319475328460037153 100319475328460037153 No Department of Cultivation and Development, Institute of Medicinal Plants, ACECR, Karaj, Iran Department of Cultivation and Development, Institute of Medicinal Plants, ACECR, Karaj, Iran A Mehrafarin A Mehrafarin 100319475328460037154 100319475328460037154 Yes Department of Cultivation and Development, Institute of Medicinal Plants, ACECR Department of Cultivation and Development, Institute of Medicinal Plants, ACECR