Journal of Medicinal Plants
فصلنامه گياهان دارویی
J. Med. Plants
Medical Sciences
http://jmp.ir
1
admin
2717-204X
2717-2058
10.61186/jmp
14
8888
13
en
jalali
1393
12
1
gregorian
2015
3
1
14
53
online
1
fulltext
en
Effects of <i>Ferulago angulata</i> Extract Against Oxidative Stress Induced by 6-hydroxydopamine in Rats
Effects of <i>Ferulago angulata</i> Extract Against Oxidative Stress Induced by 6-hydroxydopamine in Rats
فارماكولوژی و سم شناسی
Pharmacology & Toxicology
پژوهشی
Research
<div dir="ltr" style="text-align: justify;"><strong>Background:</strong> Parkinson's disease is one of the prevalent degenerative diseases of the neural system. Oxidative stress, which has been recognized as the most important factor of Parkinson's disease, plays a main role in the death of neurons in this disease. Antioxidants have a proved role in the prevention of oxidative stress. <strong>Objective:</strong> Considering the presence of evidence regarding antioxidant property of Ferulago angulata, effect of oral administration of hydroalcoholic extract of this plant was investigated on parameters of the oxidative damage caused by Parkinson's disease in adult rats. <strong>Methods:</strong> In this research, 40 Wistar rats with the average weight of 200 to 250 g were randomly assigned to 5 groups, each with 8 rats. Also, to develop Parkinson's disease animal model, 2 µl of 6-hydroxydopamine drug was injected into medial forebrain bundle on the left side of the animals and the treatment groups received Ferulago angulata extract with doses of 400, 200, and 100 mg/kg for 2 weeks as gavage. Then, the brain of the animals was isolated and parameters of Malondialdehyde and Thiol were measured. Results: Results showed that Parkinson's disease induced significantly increased brain peroxidation lipid, which is one of the factors of oxidative stress, and reduced Thiol level (p<0.001). Further, treatment of Parkinson's disease with Ferulago angulata extract significantly decreased peroxidation lipid in striatum and hippocampus and increased Thiol level (p<0.001). <strong>Conclusion:</strong> oral administration of hydroalcoholic extract of Ferulago angulata probably reduces oxidative damage and also reduces Malondialdehyde and increases Thiol in the treated groups due to its strong antioxidant property.</div>
<div dir="ltr" style="text-align: justify;"><strong>Background:</strong> Parkinson's disease is one of the prevalent degenerative diseases of the neural system. Oxidative stress, which has been recognized as the most important factor of Parkinson's disease, plays a main role in the death of neurons in this disease. Antioxidants have a proved role in the prevention of oxidative stress. <strong>Objective:</strong> Considering the presence of evidence regarding antioxidant property of Ferulago angulata, effect of oral administration of hydroalcoholic extract of this plant was investigated on parameters of the oxidative damage caused by Parkinson's disease in adult rats. <strong>Methods:</strong> In this research, 40 Wistar rats with the average weight of 200 to 250 g were randomly assigned to 5 groups, each with 8 rats. Also, to develop Parkinson's disease animal model, 2 µl of 6-hydroxydopamine drug was injected into medial forebrain bundle on the left side of the animals and the treatment groups received Ferulago angulata extract with doses of 400, 200, and 100 mg/kg for 2 weeks as gavage. Then, the brain of the animals was isolated and parameters of Malondialdehyde and Thiol were measured. Results: Results showed that Parkinson's disease induced significantly increased brain peroxidation lipid, which is one of the factors of oxidative stress, and reduced Thiol level (p<0.001). Further, treatment of Parkinson's disease with Ferulago angulata extract significantly decreased peroxidation lipid in striatum and hippocampus and increased Thiol level (p<0.001). <strong>Conclusion:</strong> oral administration of hydroalcoholic extract of Ferulago angulata probably reduces oxidative damage and also reduces Malondialdehyde and increases Thiol in the treated groups due to its strong antioxidant property.</div>
,Ferulago angulata, Malondialdehyde, Parkinson's disease, Thiol groups
Ferulago angulata, Malondialdehyde, Parkinson's disease, Thiol groups
34
44
http://jmp.ir/browse.php?a_code=A-10-109-1&slc_lang=en&sid=1
F
Sharifi
Fatemeh
Sharifi
fatemehsharifi915@yahoo.com
100319475328460041759
100319475328460041759
No
Dept. of Physiology, Shahrekord Branch, Islamic Azad University, Shahrekord Iran
گروه فیزیولوژی ، واحد شهر کرد،،دانشگاه آزاد اسلامی واحد شهرکرد، ایران
M
Rafieirad
Maryam
Rafieirad
rafieirad.m@gmail.com
100319475328460041760
100319475328460041760
Yes
Dept. of Biology, Izeh Branch, Islamic Azad University, Izeh-Iran
Dept. of Biology, Izeh Branch, Islamic Azad University, Izeh-Iran
H
Sazegar
H
Sazegar
100319475328460041761
100319475328460041761
No
Department of Physiology, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran
Department of Physiology, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran