en Effects of <i>Pinus eldarica</i> Medw. Nut Extract on Blood Glucose and Cholesterol Levels in Hypercholesterolemic Alloxan-induced Diabetic Rats فارماكولوژی و سم شناسی Pharmacology & Toxicology پژوهشی Research <div dir="ltr" style="text-align: justify;"><strong>Background:</strong> Diabetes mellitus type 2 with dyslipidemia is a common disease. Previous studies suggest that chemical constituent present in <em>Pinus eldarica</em> (<em>P. eldarica</em>) nut posesess antioxidant properties and positively affect glucose metabolism. However blood glucose and cholesterol lowering effects of <em>P. eldarica</em> nut have not been studied so far. <strong>Objective:</strong> The present study was undertaken to explore the possiblility of anti-hyperglycemic and anti-hypercholesterolemic effects of the <em>P. eldarica</em> nut extract in hypercholesterolemic diabetic rats. <strong>Methods: </strong>Sixty male wistar rats six months of age from central animal house of the institute of medicinal plants were selected. 10 rats were kept as normal group and diabetes was induced in the remaining rats by intraperitonial injection of 120 mg/kg aloxan monohydrate. After one week the diabetic rats with fasting blood glucose between 180 to 250 mg/kg were assigned to 5 groups of 10 rats each and were fed on hypercholesterolemic diet. One group was kept as control group (untreated diabetic rats) and <em>P. eldarica</em> nut extract in doses of 50, 100, 200 and 400 mg/kg was gavaged daily to the remaining rats. After one month, the fasting blood glucose, cholesterol and triglyceride levels were determined in all groups. <strong>Results: </strong>The results indicate that fasting blood glucose in 200 and 400 mg/kg <em>P. eldarica </em>nut extract treated groups significantly decreased (P=0.000 and P=0.000) and fasting blood cholesterol and triglyceride levels did not change significantly compared with control group. <strong>Conclusion:</strong> <em>P. eldarica</em> nut extract lowers blood glucose level withought affecting blood cholesterol and triglyceride levels in hypercholesterolemic diabetic rats.</div> <div dir="ltr" style="text-align: justify;"><strong>Background:</strong> Diabetes mellitus type 2 with dyslipidemia is a common disease. Previous studies suggest that chemical constituent present in <em>Pinus eldarica</em> (<em>P. eldarica</em>) nut posesess antioxidant properties and positively affect glucose metabolism. However blood glucose and cholesterol lowering effects of <em>P. eldarica</em> nut have not been studied so far. <strong>Objective:</strong> The present study was undertaken to explore the possiblility of anti-hyperglycemic and anti-hypercholesterolemic effects of the <em>P. eldarica</em> nut extract in hypercholesterolemic diabetic rats. <strong>Methods: </strong>Sixty male wistar rats six months of age from central animal house of the institute of medicinal plants were selected. 10 rats were kept as normal group and diabetes was induced in the remaining rats by intraperitonial injection of 120 mg/kg aloxan monohydrate. After one week the diabetic rats with fasting blood glucose between 180 to 250 mg/kg were assigned to 5 groups of 10 rats each and were fed on hypercholesterolemic diet. One group was kept as control group (untreated diabetic rats) and <em>P. eldarica</em> nut extract in doses of 50, 100, 200 and 400 mg/kg was gavaged daily to the remaining rats. After one month, the fasting blood glucose, cholesterol and triglyceride levels were determined in all groups. <strong>Results: </strong>The results indicate that fasting blood glucose in 200 and 400 mg/kg <em>P. eldarica </em>nut extract treated groups significantly decreased (P=0.000 and P=0.000) and fasting blood cholesterol and triglyceride levels did not change significantly compared with control group. <strong>Conclusion:</strong> <em>P. eldarica</em> nut extract lowers blood glucose level withought affecting blood cholesterol and triglyceride levels in hypercholesterolemic diabetic rats.</div> ,Pinus eldarica, nut, Blood glucose, Rat, Diabetes, Hypercholesterolemia Pinus eldarica, nut, Blood glucose, Rat, Diabetes, Hypercholesterolemia 68 74 http://jmp.ir/browse.php?a_code=A-10-65-2&slc_lang=en&sid=1 H Fallah huseini H Fallah huseini 100319475328460042153 100319475328460042153 No Pharmacology & Applied Medicine Department of Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR Pharmacology & Applied Medicine Department of Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR S Mehrzadi S Mehrzadi 100319475328460042154 100319475328460042154 No Pharmacology & Applied Medicine Department of Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR Pharmacology & Applied Medicine Department of Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR H Ghaznavi H Ghaznavi 100319475328460042155 100319475328460042155 No Department of Pharmacology, School of Medicine, Iran University of Medical Sciences Department of Pharmacology, School of Medicine, Iran University of Medical Sciences Y Tajallizadehkhoob Y Tajallizadehkhoob 100319475328460042156 100319475328460042156 No Endocrinology & Metabolism Research Institute, Tehran University of Medical Sciences Endocrinology & Metabolism Research Institute, Tehran University of Medical Sciences H Fakhrzadeh H Fakhrzadeh Fakhrzad@tums.ac.ir 100319475328460042157 100319475328460042157 Yes Endocrinology & Metabolism Research Institute, Tehran University of Medical Sciences Endocrinology & Metabolism Research Institute, Tehran University of Medical Sciences