en Hypnotic Effect of <i>Salvia reuterana</i> Boiss for Treatment of Insomnia فارماكولوژی و سم شناسی Pharmacology & Toxicology پژوهشی Research <div dir="ltr" style="text-align: justify;"><strong>Background:</strong> Insomnia, which is difficulty in initiating and maintaining sleep, is a very common experience for many people. Considering the increasing interest in medicinal plants in the past decade, many plants such as <em>Coriandrum sativum</em>, <em>Salvia leriifolia</em>, <em>Salvia reuterana</em> and <em>Stachys lavanduli</em> folia have been used in Iranian traditional medicine to abate insomnia. <strong>Objective:</strong> The present study was designed to investigate hypnotic effect of <em>Salvia reuterana</em> on male mice. <strong>Methods:</strong> Ethanolic extract of <em>S. reuterana</em> was prepared. Five groups of 6 animals each were pretreated with vehicle, <em>Salvia</em> extract (50, 100 and 250 mg/kg i.p.) or diazepam (0.5mg/kg i.p.) 30 minutes before ketamine injection (100 mg/kg, i.p.). <em>Results:</em> The latency and total sleeping times were recorded to determine the hypnotic effect of the extract. The results indicated that ethanolic extract of <em>S. reuterana</em>, reduced the latency time and induced the total sleeping time in a dose dependent manner, compared to saline group. <strong>Conclusion:</strong> The present study suggests that <em>S. reuterana</em> produces hypnotic effect which can be evaluated clinically.</div> <div dir="ltr" style="text-align: justify;"><strong>Background:</strong> Insomnia, which is difficulty in initiating and maintaining sleep, is a very common experience for many people. Considering the increasing interest in medicinal plants in the past decade, many plants such as <em>Coriandrum sativum</em>, <em>Salvia leriifolia</em>, <em>Salvia reuterana</em> and <em>Stachys lavanduli</em> folia have been used in Iranian traditional medicine to abate insomnia. <strong>Objective:</strong> The present study was designed to investigate hypnotic effect of <em>Salvia reuterana</em> on male mice. <strong>Methods:</strong> Ethanolic extract of <em>S. reuterana</em> was prepared. Five groups of 6 animals each were pretreated with vehicle, <em>Salvia</em> extract (50, 100 and 250 mg/kg i.p.) or diazepam (0.5mg/kg i.p.) 30 minutes before ketamine injection (100 mg/kg, i.p.). <em>Results:</em> The latency and total sleeping times were recorded to determine the hypnotic effect of the extract. The results indicated that ethanolic extract of <em>S. reuterana</em>, reduced the latency time and induced the total sleeping time in a dose dependent manner, compared to saline group. <strong>Conclusion:</strong> The present study suggests that <em>S. reuterana</em> produces hypnotic effect which can be evaluated clinically.</div> Hypnotic effect, Insomnia, Ketamin-induced sleeping time, Salvia reuterana, Hypnotic effect, Insomnia, Ketamin-induced sleeping time, Salvia reuterana 7 13 http://jmp.ir/browse.php?a_code=A-10-104-1&slc_lang=en&sid=1 G Vaseghi G Vaseghi 100319475328460042133 100319475328460042133 No Physiology Research Center, Isfahan University of Medical Sciences Physiology Research Center, Isfahan University of Medical Sciences S Andalib S Andalib 100319475328460042134 100319475328460042134 No Neurosciences Research Center, Tabriz University of Medical Sciences Neurosciences Research Center, Tabriz University of Medical Sciences M Rabbani M Rabbani rabanim@yahoo.com 100319475328460042135 100319475328460042135 Yes Department of Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences Department of Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences SE Sajjadi SE Sajjadi 100319475328460042136 100319475328460042136 No Department of Pharmacognosy, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences Department of Pharmacognosy, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences A Jafarian A Jafarian 100319475328460042137 100319475328460042137 No Department of Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences Department of Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences