RT - Journal Article T1 - Bioengineering of Important Secondary Metabolites and Metabolic Pathways in Fenugreek (Trigonella foenum-graecum L.) JF - jmpir YR - 2010 JO - jmpir VO - 9 IS - 35 UR - http://jmp.ir/article-1-262-fa.html SP - 1 EP - 18 K1 - Fenugreek K1 - Secondary metabolites K1 - Metabolic Pathways K1 - Diosgenin K1 - Trigonelline AB - Fenugreek (Trigonella foenum-graecum L.) has a long and respected history of medicinal uses in Middle East and Persian medicine. The hypocholesterolaemic and hypoglycaemic effects of fenugreek were attributed to its major steroidal sapogenin, diosgenin and its major alkaloid, trigonelline. The knowledge of diosgenin and trigonelline biosynthesis is derived from studies of cholesterol and nicotinic acid production through acetyl-CoA→ mevalonate→ isopentenyl pyrophosphate→ squalene→ lanosterol→ cholesterol→ diosgenin and quinolinic acid→ nicotinamide adenine dinucleotide→ nicotinamide→ nicotinic acid→ trigonelline pathways, respectively. This paper reviews the secondary metabolites and metabolic pathways of diosgenin and trigonelline production in fenugreek as a medicinal plant and economical crop. LA eng UL http://jmp.ir/article-1-262-fa.html M3 ER -