TY - JOUR JF - jmpir JO - J. Med. Plants VL - 11 IS - 44 PY - 2012 Y1 - 2012/11/01 TI - The Effect of Tanacetum sonbolii Hydroalcholic Extract on PTZInduced Seizures in Male Mice TT - بررسی اثر عصاره هیدروالکلی گیاه Tanacetum sonbolii بر تشنج های ناشی از پنتیلن تترازول در موش سوری N2 - Background: Epilepsy has prevalence about 0.5 - 1% of world population. From many years ago, plants used to treat of various neurological diseases such as seizures. Objective: The anticonvulsant effects of hydroalcoholic extract of Tanacetum sonbolii was examined in male mice. Methods: 60 mice were randomly divided into six groups (n=10), included: A control group (normal saline) and 5 groups receiving Sonbolii extract (150, 300, 600, 900, 1200 mg/kg). 30 min after peritoneal injection of different doses extract or saline, PTZ (85 mg/kg) were injected and the animal immediately transferred to a special cage, and the seizure behavior was evaluated within 30 minutes. Results: The tonic and colonic seizures were significantly reduced in the groups that received extract compared to control group. The onsets of seizures were difference between treated and control animals statistically. Extract were reduced the rate of death during seizures and was prevented the outbreak of tonic - colonic seizures in some case. Conclusion: Our results showed that the extracts of Tanacetum sonbolii have strong anticonvulsant effect, and more complementary studies will be done for identifying the mechanism of action and effective material of Sonbolii exact. SP - 193 EP - 201 AU - Naderi, F AU - Azhdari-Zarmehri, H AU - Erami, E AU - Sonboli, A AU - Sofiabadi, M AU - Mohammad-Zadeh, M AD - Cellular and Molecular Research Center, Department of Physiology and Pharmacology, Sabzevar University Of medical Sciences, Sabzevar KW - Tanacetum sonbolii KW - Seizures KW - PTZ KW - Mice UR - http://jmp.ir/article-1-133-en.html ER -