year 1, Issue 1 (3-2002)                   J. Med. Plants 2002, 1(1): 69-76 | Back to browse issues page

XML Persian Abstract Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Asgary S, Naderi G, Bashardoost N, Etminan Z. Antioxidant effect of the essential oil and extract of Matricaria chamomilla L. on isolated rat hepatocytes. J. Med. Plants 2002; 1 (1) :69-76
URL: http://jmp.ir/article-1-823-en.html
1- Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences, Isfahan, Iran , Isfcarvasrc@hotmail.com
2- Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
Abstract:   (7272 Views)
Free radicals are active molecules that are present every where and may be of internal or external origin. One of the most important destructive effects of free radicals is promoting lipid peroxidation resulting membrane destruction. This process causes the destruction of membrane and changing activities of intra membrane enzymics and other proteins and releasing radicals that is initially harmful to cells. In this study essential oil and extract of Matricuria chamonilla and pure essential oil (Azulone) are emphasised to be studied as antioxidants and free radical scavenger. Tershio Butyl Hydroperoxide (t-BIT) was used because of its capability to produce lipid peroxidation. Varied compounds were used in three concentrations. The produced malondialdehyde (MDA) was measured by the spectrophotometrie at 535 mm. Also, the enzymatic activities of LDH and AST were measured. Thenc enzymes are as markers for determining lipid peroxidation levels and decreasing their activity indicate the inhibitoty power of the treated compound. The highest level for inhibition of MDA production were respectively Matricaria chamomilla (essential oil) (58%)> azulene (35.4%) > Matricaria chamomilla (extract) (16%). There is a direct relationship between MDA level with enzymatic activities of LDH and AST. Results indicate the antioxidant effect of Matricaria chomomilla. Surely, it is required to wide spread in vivo study on these compounds to determine side effects and appropriate doses for the best efficacy and clinical usages.
Full-Text [PDF 242 kb]   (3572 Downloads)    
Type of Study: Research | Subject: Pharmacology & Toxicology
Received: 2001/05/15 | Accepted: 2002/02/23 | Published: 2002/03/15

Add your comments about this article : Your username or Email:
CAPTCHA

Send email to the article author


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2024 CC BY-NC 4.0 | Journal of Medicinal Plants

Designed & Developed by : Yektaweb