year 5, Issue 17 (3-2006)                   J. Med. Plants 2006, 5(17): 32-38 | Back to browse issues page

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1- Department of Biology, Faculty of Sciences, Isfahan University , h.madani@sci.ui.ac.ir
2- Isfahan Cardiovascular Research Center, Isfahan University of Medical Scinnces
3- Department of Biology, Faculty of Sciences, Isfahan University
Abstract:   (5521 Views)
Background: Plant phenolic compounds such as flavonoids have important role in treatment of many diseases. Also some of them have potent hepatoprotective effects. Objective: In this study, we have investigated the protective effects of polyphenolic extracts of Silybum marianum and Chichorium intybus on thioacethamide-induced hepatotoxicity in rat. Methods: Extracts were injected to rats, at a dose of 25 mg/kg body weight together with thioacetamide at a dose of 50 mg/kg body weight. For investigation of the hepatoprotective effect of extracts against thioacetamide, activity of aminotransferases (SGOT and SGPT), alkalin phosphatase, bilyrubin, Na+ and K+ were measured. Results: significant decreases were observed in activities of aminotransferases, alkalin phosphatase and bilyrubin in groups that treated with extracts together with thioacetamide in comparation with thioacetamide treated group. Level of Na+,K+ and liver weight betwen different groups had not significant different. Conclusions: This results showed protective effect of chichorium extracts on thioacetamide-induced hepatotoxicity in rat.
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Type of Study: Research | Subject: Pharmacology & Toxicology
Received: 2004/05/10 | Accepted: 2004/11/23 | Published: 2006/03/20

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