سال 9، شماره 33 و S6 - ( supplement 6 1388 )                   سال 9 شماره 33 و S6 صفحات 34-29 | برگشت به فهرست نسخه ها

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1- Traditional Medicine and Materia Medica Research Center, Shahid Beheshti University of Medical Sciences, Tehran
2- Department of Medicinal Chemistry and Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran ، sesebrahimi@sina.tums.ac.ir
3- Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran
4- Department of Medicinal Chemistry and Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran
چکیده:   (4145 مشاهده)

  Background: The seeds of Trigonella foenum-graecum L. (Fenugreek) are used in Iranian traditional medicine as blood sugar lowering agent. According to last investigations, hypoglycemic property is related to the amino acids of the plant specially 4-hydroxyisoleucine.

  Objective: In this research, identification and quantitative determination of 4-hydroxyisoleucine in Fenugreek seeds from Shahreza, central part of Iran, has been investigated.

  Methods: Powdered seeds of the plant were defatted and then extracted by using ethanol 50%. In order to isolation of 4-hydroxyisoleucine from the extract, ion exchange chromatography was used and the amino acid content was determined by using high performance liquid chromatography technique.

  Results: The results showed the presence of 0.4% 4-hydroxyisoleucine in the plant seeds which is considerable amount of the amino acid in the plant collected from Iran.

Conclusion: According to the effects of 4-hydroxyisoleucine such as antihyperglycemic and antihyperlipidemic properties, fenugreek can be considered as an herbal remedy in supportive treatment of these disorders.
واژه‌های کلیدی: <، i>، Trigonella foenum-graecum<، /i>، Amino acid، Diabetes، 4-hydroxyisoleucine
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نوع مطالعه: پژوهشی | موضوع مقاله: فارماكوگنوزی و فارماسيوتيكس
دریافت: 1388/9/17 | پذیرش: 1388/12/1 | انتشار: 1388/12/28

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