year 9, Issue 33 And S6 (supplement 6 2010)
J. Med. Plants 2010, 9(33 And S6): 1-28 |
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1- Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Islamic Republic of Iran, Tehran
2- Genetical Biochemistry and Signal Biology, Graduate School of Medical Sciences, Kitasato University, 1-15-1 Kitasato, Sagamihara 228-8555, Japan , ken@kitasato-u.ac.jp
3- Cultivation and Development Department, Institute of Medicinal Plants, ACECR, Karaj
4- Department of Pharmacognosy and Pharmaceutics, Institute of Medicinal Plants, ACECR, Tehran
2- Genetical Biochemistry and Signal Biology, Graduate School of Medical Sciences, Kitasato University, 1-15-1 Kitasato, Sagamihara 228-8555, Japan , ken@kitasato-u.ac.jp
3- Cultivation and Development Department, Institute of Medicinal Plants, ACECR, Karaj
4- Department of Pharmacognosy and Pharmaceutics, Institute of Medicinal Plants, ACECR, Tehran
Abstract: (6830 Views)
The extract of licorice (Glycyrrhiza glabra L.) has been widely used for many centuries in the traditional Chinese medicine as native anti-allergic agent. Glycyrrhizin (GL), a triterpenoid-saponin, extracted from the roots of licorice is the most effective compound for inflammation and allergic diseases in human body. The biological and pharmacological studies revealed that GL possesses many pharmacological effects, such as anti-inflammatory, anti-viral and liver protective effects, and the biological effects, such as induction of cytokines (interferon-g and IL-12), chemokines as well as extrathymic T and anti-type 2 T cells. This review describes (i) the pharmacological property of GL as an effective anti-inflammatory and anti-viral drug (ii) the biochemical characteristics of several GL-binding proteins (gbPs) involved in the anti-inflammatory and anti-viral effects of 68GL and the GL-induced selective inhibition of the phosphorylation of these gbPs by GL-binding protein kinases in vitro and (iii) the mechanisms involved in the GL-induced inhibition of the replication of both RNA and DNA viruses. In addition, recent reports concerning the mechanical actions involved in the anti-inflammatory and anti-viral effects of GL in vivo and in vitro and its clinical effects on chronic active liver disease and viral infection are summarized.
Type of Study: Research |
Subject:
Pharmacognosy & Pharmaceutics
Received: 2009/11/9 | Accepted: 2010/02/24 | Published: 2010/03/19
Received: 2009/11/9 | Accepted: 2010/02/24 | Published: 2010/03/19
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