year 8, Issue 30 (5-2009)                   J. Med. Plants 2009, 8(30): 152-156 | Back to browse issues page

XML Persian Abstract Print


1- Food and Drug Laboratory Research center (FDLRC), Tehran, Iran
2- Quality Control Unit, Pastour Institute of Iran, Tehran, Iran
3- Pharmacy Science Branches, Islamic Azad University, Tehran, Iran
4- Food and Drug Laboratory Research center (FDLRC), Tehran, Iran , piralihm@tums.ac.ir
Abstract:   (6424 Views)
Background: Natural flavors essential oils are almost present in various food stuffs, cosmetic and pharmaceutical products. Safety assessment of these food additives should be seriously considered as long as their due wide applications are favorable. Objective: Natural flavors essential oils are widely used in various foods, cosmetic and pharmaceutical products. These kinds of additives are applied as colors, preservatives, aroma, antioxidant agents and tasting agents. In some cases, it may happen that the large use of some of these additives may accompany with some concerns and unwanted toxic disturbs. Methods: In this study, Concentrations of 24, 12, 6, 3, 1.5, 0.75, 0.375, 0.1875 ppm (µg/ml) of three essential oils, Eugenia caryophyllata, Thymus vulgaris and Zataria multiflora, were tested in MTT assay with three cell line Vero, Hep2, Hela. Results: All three Essential oils and extracts were shown cytopathological effects on three cell lines in MTT assay in at least 0.04 µg/ml to maximum 3.0 µg/ml concentrations. Conclusion: Based on obtained results, all studied essential oils and extracts may have cytopathologic effect in specific concentrations so suggested using of these compound should be performed with considering their proper concentration and more safety studies on them.
Full-Text [PDF 1145 kb]   (2515 Downloads)    
Type of Study: Research | Subject: Pharmacology & Toxicology
Received: 2009/02/25 | Accepted: 2009/05/26 | Published: 2009/06/19

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.