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Naderi G, Khalili M, Karimi M, Soltani M. The Effect of Oral and Intraperitoneal Administration of Acorus calamus L. Extract on Learning and Memory in Male Rats. J. Med. Plants 2010; 9 (34) :46-56
URL: http://jmp.ir/article-1-283-en.html

Background: Learning and memory impairment during aging mind have a disturbance role in human life. Regarding to the defect mechanisms for prevention or treatment of memory loss, the new strategies were recommended for study on it. Objective: Importance of herbal medicine treatment encouraged us to examine the effect of a candidate plant Acorus calamus for improvement of learning and memory. Methods: Male rats were randomly divided to control and treatment groups. In treatment group the plant were applied to animals in oral (plant/ food ratio = % 6.25) for two weeks and in injected groups the plant extract were applied (i.p) to rat in 25, 50 and 100 mg/kg). Finally, all experimental animal groups were conducted to Y maze and shuttle box tests in order to obtain spatial recognition and acquisition – recalling data, respectively. Results: The step through latency (STL) time resulted from oral and 100 mg/kg injected dose groups show a significant difference with control animals. Also, alternation behavior (%) obtained from Y maze test data was marked than control rats. Conclusion: The present study show that oral and intraperitoneal administration of the extract in higher dose could have increase spatial recognition and recalling the data,