year 18, Issue 72 (11-2019)
J. Med. Plants 2019, 18(72): 170-182 |
Back to browse issues page
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Ebrahimzadeh Zgemi S, Golmakani N, Asili M, Naseri A, Mohebbi Dehnavi Z, Kamali Z et al . A Comparative Study on the Effect of Artemisia and Clotrimazole Vaginal Cream on Vaginal Candida Infection on Non-Pregnant Women in Fertile Age in Mashhad in 2016-2017: A Triple Blind Clinical Trial. J. Med. Plants 2019; 18 (72) :170-182
URL: http://jmp.ir/article-1-2714-en.html
URL: http://jmp.ir/article-1-2714-en.html
S Ebrahimzadeh Zgemi1 
, N Golmakani2 , MJ Asili3 , A Naseri4 , Z Mohebbi Dehnavi5 , Z Kamali6 , A Saber Mohammad * 7
, N Golmakani2 , MJ Asili3 , A Naseri4 , Z Mohebbi Dehnavi5 , Z Kamali6 , A Saber Mohammad * 7
1- PhD student in Reproductive Health, Faculty member of midwifery, Department of Midwifery, Mashhad University of Medical Sciences, Mashhad, Iran
2- Assistant professor of Midwifery, Faculty Member of Mashhad University of Medical Sciences, Department of midwifery, Mashhad, Iran
3- Assistant professor of Pharmacy, Faculty member of Mashhad University of Medical Sciences, Department of Pharmacy, Mashhad, Iran
4- Assistant professor of Parasitology & Mycology, Faculty member of Mashhad University of Medical Sciences, Department of Parasitology & Mycology, Mashhad, Iran
5- Master of Midwifery, Faculty of Nursing and Midwifery, Isfahan University of Medical Sciences, Isfahan, Iran
6- Department of Midwifery, School of Nursing and Midwifery, Mashhad University of Medical Sciences, Mashhad, Iran
7- Master of Midwifery, Department of Midwifery, Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran , saberma921@mums.ac.ir
2- Assistant professor of Midwifery, Faculty Member of Mashhad University of Medical Sciences, Department of midwifery, Mashhad, Iran
3- Assistant professor of Pharmacy, Faculty member of Mashhad University of Medical Sciences, Department of Pharmacy, Mashhad, Iran
4- Assistant professor of Parasitology & Mycology, Faculty member of Mashhad University of Medical Sciences, Department of Parasitology & Mycology, Mashhad, Iran
5- Master of Midwifery, Faculty of Nursing and Midwifery, Isfahan University of Medical Sciences, Isfahan, Iran
6- Department of Midwifery, School of Nursing and Midwifery, Mashhad University of Medical Sciences, Mashhad, Iran
7- Master of Midwifery, Department of Midwifery, Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran , saberma921@mums.ac.ir
Abstract: (3819 Views)
Background: About 75% of women experience at least one vulvovaginal candidiasis during their life. Clotrimazole is an antifungal drug that has side effects along with its therapeutic properties. For this reason, a large percentage of women tend to use natural herbal treatments. Artemisia is an anti-fungal activity.
Objective: The aim of this study was to compare the effect of Artemisia vulgaris and Clotrimazole on vaginal candida infection on non pregnant women in fertility ages.
Methods: This study is a triple blind clinical trial performed on 72 non-pregnant women in Mashhad in 2016-2017 years. The research units were divided into two groups (receiving Artemisia Vaginal Cream and receiving Clotrimazole Vaginal Cream). After confirmation of candidacy and having consent for participation, by random allocation and treated for seven nights. After the treatment, the data was analyzed using SPSS software (version 24).
Results: After treatment, the score for candidate vaginal symptoms was not significant in Artemisia and Clotrimazole group based on Mann-Whitney test (P = 0.518). The Wilcoxon test showed a significant reduction in the symptoms of vaginal candida infection before and after treatment in both groups of Artemisia (P <0.001) and clotrimazole (P <0.001).
Conclusion: Due to the similar effects of Artemisia and Cholitrimazole, Artemisia can be used as an alternative treatment for vaginal candidiasis due to less side effects.
Objective: The aim of this study was to compare the effect of Artemisia vulgaris and Clotrimazole on vaginal candida infection on non pregnant women in fertility ages.
Methods: This study is a triple blind clinical trial performed on 72 non-pregnant women in Mashhad in 2016-2017 years. The research units were divided into two groups (receiving Artemisia Vaginal Cream and receiving Clotrimazole Vaginal Cream). After confirmation of candidacy and having consent for participation, by random allocation and treated for seven nights. After the treatment, the data was analyzed using SPSS software (version 24).
Results: After treatment, the score for candidate vaginal symptoms was not significant in Artemisia and Clotrimazole group based on Mann-Whitney test (P = 0.518). The Wilcoxon test showed a significant reduction in the symptoms of vaginal candida infection before and after treatment in both groups of Artemisia (P <0.001) and clotrimazole (P <0.001).
Conclusion: Due to the similar effects of Artemisia and Cholitrimazole, Artemisia can be used as an alternative treatment for vaginal candidiasis due to less side effects.
Type of Study: Research |
Subject:
Pharmacology & Toxicology
Received: 2017/12/22 | Accepted: 2018/08/26 | Published: 2019/10/28
Received: 2017/12/22 | Accepted: 2018/08/26 | Published: 2019/10/28
References
1. R. N. Comparison the effectiveness of cinnamon oral capsule with clotrimazole vaginal cream for treatment of women with vaginal candidiasis at centers of Shahid Beheshti University Medical Sciences 2013. Masters Thesis: Tehran, Iran: Shahid Beheshti University Faculty of Midwifery and Nursing. 2013.
2. Fouladi Z, Afshari P, Gharibi T and Dabbagh M. The comparison of Zataria multiflora boiss (Avishan Shirazi) and Clotrimazol vaginal cream in the treatment of candidiasis vaginitis. ISMJ. 2009; 12 (12): 214-24.
3. Mousavi M, Keshavarz T, Montaseri H, Pakshir K, Yazdani M and Zare N. A comparative study on the therapeutic effect of the propolis vaginal cream and clotrimazole on candida vulvovaginitis in reproductive aged women. J. Isfahan Med. Sch. 2011; 28 (117): 1-9.
4. Banaean-Boroujeni S, Rasti-Boroujeni M, Moghim H, Validi M, Mobini G and Kazemian A. In vitro effect of honey on Candida albicans and lactobacillus. J. Shahrekord Univ. Med. Sci. 2010; 11 (4): 52-8.
5. Seyed Mazhari M and Tudeh Fallah F. A comparative study of vaginal candidiasis in pregnant and non-pregnant women. J. the Nursing Academy of the Islamic Republic of Iran. 2009; 9 (1): 18-20.
6. Gharekhani P, Sadatin A. Cardinal manifestations & management of diseases (CMMD). Tehran: Noure Danesh. 2005.
7. Dunnihoo D. Fundamentals of gynecology and obstetrics. New York: Lippincott. 2010.
8. Wilson E. Recurrence of Vulvovaginal candidacies during pregnancy, obstet, Gynecol. 2002; 48 (4): 491-494.
9. Break J. Break and Novak's gynecology. Volum 1 Chapter 14. Genetic Urinary infection and Sexuality Transmitted Diseases, Lippincott Williams & Wilkins. 14th ed. 2012, pp: 545-7.
10. Saebi S. Clinical Iran Generic Drugs. 5th ed, Aeig. 2001, p: 243.
11. Jafari Nodoushan A, Dehghani M and Mirbagheri S. In vitro Antifungal Effect of Aqueous Garlic (Allium Sativum) Extract and its Combination with fluconazole against five common clinical candida isolated from candidiasis lesions. J. Kerman Univ. Med. Sci. 2007; 14 (3): 153-62.
12. Katiraee F, Eidi S, Bahonar A, Zarrinfar H and Khosravi A. Comparision of MICs of some Iranian Herbal Essences Against Azole Resistance and Azole Susceptible of Candida albicans. J. Med. Plants 2008; 7 (27): 37-44.
13. Horiuchi K, Shiota S, Kuroda T, Hatano T, Yoshida T and Tsuchiya T. Antimicrobial activity of Oleanolic Acid from Saliva officinalis and related compounds on vancomycin-resistant enterococci. Biol. Pharm. Bull. 2007; 30 (6): 1147-9. [DOI:10.1248/bpb.30.1147]
14. Mousavi Z, Keshavarz T, Pakshir K, Yazdani M, Zare N and Afrouzan H. A Comparative Study on the Therapeutic Effect of the Propolis Vaginal Cream and Clotrimazole on Candida Vulvovaginitis in Reproductive Aged Women. J. Isfahan Medical School 2011; 28 (117): 1-9.
15. Santomauro F, Donato R, Sacco C, Pini G, Flamini G and Bilia A. Vapour and Liquid-Phase Artemisia annua Essential Oil Activities against Several Clinical Strains of Candida. Planta Med. 2016; 82 (11-12): 1016-20. [DOI:10.1055/s-0042-108740]
16. Juteau F, Jerkovic I, Masotti V, Milos M, Mastelic J and Bessiere J. Composition and antimicrobial activity of the essential oil of Artemisia absinthium from Croatia and France. Planta Med. 2003; 69 (2): 158-61. [DOI:10.1055/s-2003-37714]
17. Masoudi S, Rustaiyan A and Vahedi M. Volatile oil constituents of different parts of Artemisia chamaemelifolia and the composition and antibacterial activity of the aerial parts of Aturcomanica from Iran. Nat. Prod. Commun. 2012; 7 (11): 1519-22. [DOI:10.1177/1934578X1200701127]
18. Choi E, Park H, Lee J and Kim G. Anticancer, antiobesity, and anti-inflammatory activity of Artemisia species in vitro. J. Tradit. Chin. Med. 2013; 33 (1): 92-7. [DOI:10.1016/S0254-6272(13)60107-7]
19. Habibi Z, Ghanian S, Ghasemi S and Yousefi M. Chemical composition and antibacterial activity of the volatile oil from seeds of Artemisia annua L. from Iran. Nat. Prod. Res. 2013; 27 (2): 198-200. [DOI:10.1080/14786419.2012.662652]
20. Kazemi M, Dakhili M, Dadkhah A, Yasrebifar Z and Larijani K. Composition, antimicrobial and antioxidant activities of the essential oil of Artemisia kermanensis Podl, an endemic species from Iran. J. Med. Plants Res. 2011; 5 (18): 4481-6.
21. Ghlissi Z, Sayari N, Kallel R, Bougatef A and Sahnoun Z. Antioxidant, antibacterial, anti-inflammatory and wound healing effects of Artemisia campestris aqueous extract in rat. Biomed. Pharmacother. 2016; 84: 115-22. [DOI:10.1016/j.biopha.2016.09.018]
22. Hakimi Meybodi MH, Afkhami Aghad M and Mir Jalili F. An investigation into biological activities of A. persica's essential oil. Pajouhesh & Sazandegi 2004; 16 (4): 2-5.
23. Naeini A, Naseri M, Kamalinejad M, Khoshzaban F, Rajabian T, Nami H and et al . Study on Anti_ Candida Effects of Essential Oil and Extracts of Iranian Medicinal Plants, In vitro. J. Med. Plants 2011; 2 (38): 163-172.
24. Obistioiu D, Cristina R, Schmerold I, Chizzola R, Stolze K and Nichita I. Chemical characterization by GC-MS and in vitro activity against Candida albicans of volatile fractions prepared from Artemisia dracunculus, Artemisia abrotanum, Artemisia absinthium and Artemisia vulgaris. Chem. Cent. J. 2014; 8 (1): 6. [DOI:10.1186/1752-153X-8-6]
25. Teamori F and Rezae S. Iranian generic drugs with nursing and care measures. Tehran: Arian teb. 2015, p: 1262.
26. Tan J, Zhang J, Chen W, Sun Y, Wan Z and Li R. The A395T mutation in ERG11 gene confers fluconazole resistance in Candida tropicalis causing candidemia. Mycopathologia 2015; 179 (3-4): 213-8. [DOI:10.1007/s11046-014-9831-8]
27. White D, Johnson E and Warnock D. Management of Persistent Vulvovaginal Candidiasis due to azole resistant Candidia glabralata. Genitourin. Med. 1993; 6 (2): 112-4. [DOI:10.1136/sti.69.2.112]
28. Mikamo H, Kawazoe K, Sato Y, Hayasaki Y and Tamaya T. Comparative study on the effectiveness of antifungal agents in different regimens against vaginal Candidiasis. Chemotherapy 1998; 44 (5): 364-81. [DOI:10.1159/000007136]
29. Fouladi Z, Afshari P, Gharibi T and Dabbagh M. The comparison oF Zataria multiflora boiss (Avishan Shirazi) and Clotrimazol vaginal cream in the treatment of candidiasis vaginitis. ISMJ. 2009; 12 (3): 214-24.
30. Khosravi AR, Eslami AR, Shokri H, Kashanian M. Zataria multiflora cream for the treatment of acute vaginal candidiasis. International Journal of Gynecology and Obstetrics 2008; 101 (2): 201-202. [DOI:10.1016/j.ijgo.2007.11.010]
31. Katiraee F, Eidi S, Bahonar A, Zarrinfar H, Khosravi A. Comparision of MICs of some Iranian Herbal Essences Against Azole Resistance and Azole Susceptible of Candida Albicans. J. Med Plants 2008; 3 (27): 37-44.
32. Akbari S. Antifungal Effects of Thyme and Marjoram Plant Extract on Clinical Isolates of Candida Albic Acid Resistant and Fluconazole Sensitive. J. Med. Plants (Special Issue of Plants with Antimicrobial Effects). 2006; 1 (Sup. 3): 53-62.
33. Janani F, Delfan B, Toulabi T, Ebrahim zadeh F and Motamedi M. Comparative study of effect of myrtus vaginal cream and clotrimazol vaginal cream in the treatment of vaginal candidiasis. Scientific Magazine Yafte. 2011; 13 (1): 32-41.
34. Sobel J, Brooker D, Stein G, Thomason J, Wermeling D and Bradley B. Single oral dose fluconazole compared with conventional clotrimazole topical therapy of Candida vaginitis. American J. Obstetrics and Gynecol. 1995; 172 (4): 1263-8. [DOI:10.1016/0002-9378(95)91490-0]
35. Kariman N, Afrakhteh M, Valaii N and Ahmadi M. Comparison of the effect of fluconazole and clotrimazole in the treatment of vulvovaginal candida albicans. J. Kermanshah University of Medical Sciences 2008; 6 (3): 9-16.
36. Bahadori F, Diba K, Yekta Z and Namaki A. Comparison of Fluconazole and Clotrimazole in the Treatment of Acute Candida Albicans Vulvovaginitis. J. Family and Reproductive Health 2008; 2 (4): 179-83.
37. Roozbahani F, Kariman N, Mojab F and Nasiri M. Effect of Myrtus communis capsule on vaginal candidiasis treatment. Pajoohandeh J. 2013; 18 (5): 242-9.
38. Kordi M, Rakhshandeh H and Gholami H. Comparison of the effect of garlic extract vaginal douche and clotrimazol vaginal cream in the treatment of women with vaginal candidiasis. Iranian Journal of Obstetrics, Gynecology and Infertility 2005; 8 (2): 33-42.
39. Fouladi Z, Afshari P, Gharibi T and Dabbagh M. The comparison oF Zataria multiflora boiss (Avishan Shirazi) and Clotrimazol vaginal cream in the treatment of candidiasis vaginitis. Iranian South Medical J. 2009; 12 (3): 214-24.
40. Mousavi M, Pakshir K, Yazdani M, Zare N and Afrouzan H. Comparison of the effects of bee propolis cream clotrimazole vaginal cream in the treatment of fungal infections of the vagina in women of childbearing age. J. Isfahan Medical School 2011; 28 (117): 1099-1107.
Send email to the article author
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
