year 9, Issue 35 (9-2010)                   J. Med. Plants 2010, 9(35): 88-92 | Back to browse issues page

‎ 20.1001.1.2717204.2010.9.35.9.9

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Cytotoxic Effects of Essential Oils and Extracts of some Mentha species on Vero, Hela and Hep2 Cell Lines
N Rahimifard1 , H Hajimehdipoor * 2, MH Hedayati3 , O Bagheri4 , H Pishehvar5 , Y Ajani6
1- Department of Microbiology, Food and Drug Laboratory Research Center (FDLRC), MOH & ME
2- Traditional Medicine and Materia Medica Research Center, Shahid Beheshti University of Medical Sciences , Hajimehd@tums.ac.ir
3- Department of Biotechnology, Pasture Institute of Iran
4- Molecular Biotechnology Research Center, Baqiatalah University of Medical Sciences
5- Department of Microbiology, Pharmaceutical Sciences Branch, Islamic Azad University
6- Department of Pharmacognosy and Pharmaceutics, Institute of Medicinal Plants, ACECR
Abstract:   (5405 Views)
Background: Mentha species are widely used in traditional medicine mostly as anti-flatulence. Nowadays, their usage as flavor and preservative in food, cosmetic and pharmaceutical industries has been developed. Moreover, cytotoxic effects of some Mentha species have been reported. Objective: In this study, cytotoxic properties of Mentha piperita, M. spicata, M. aquatica, M. crispa, M. pulegium and M. longifolia have been investigated. Methods: Different concentrations of essential oils and total extracts of six Mentha species were tested by MTT assay against Vero, Hep2 and Hela cell lines. Results: The results showed that all samples were toxic against Vero, Hela and Hep2 cell lines (IC50 28.1-166.2 µg/ml). Conclusion: All examined Mentha species extracts and essential oils have cytotoxic effects but some of them could be considered as potent toxic agents.
Keywords: <, i>, Mentha<, /i>, Cytotoxic effects, MTT, Vero, Hela, Hep2 cell line
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Type of Study: Research | Subject: Pharmacognosy & Pharmaceutics
Received: 2010/06/4 | Accepted: 2010/08/28 | Published: 2010/10/29
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