year 19, Issue 73 (3-2020)                   J. Med. Plants 2020, 19(73): 71-81 | Back to browse issues page


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Niazi R, Peeri M, Azarbayjani M A. Antiapoptotic and antioxidant effects of resistance training with berberine consumption on diazinon induced cardiotoxicity in rats. J. Med. Plants 2020; 19 (73) :71-81
URL: http://jmp.ir/article-1-2535-en.html
1- Department of Exercise Physiology, Central Tehran Branch, Islamic Azad University, Tehran, Iran
2- Department of Exercise Physiology, Central Tehran Branch, Islamic Azad University, Tehran, Iran , m.peeri@iauctb.ac.ir
Abstract:   (2871 Views)
Background: Increasing use of pesticides is one of the health hazards. Physical activity and medicinal plants appear to be a strategy to mitigate the adverse effects of these substances. Objective: The purpose of this study was to investigate the effect of resistance training and berberine chloride on apoptosis and oxidative stress markers in the heart tissue of diazinon-infected rats. Methods: In this study, 80 rats were randomly assigned into 8 groups of 10 animals in each group, including: 1) healthy control, 2) sham, 3) diazinon, 4) diazinon + resistance training, 5) diazinon + berberine (2.5 mg/kg) 6) diazinon + berberine (15 mg/kg), 7) diazinon + resistance training and berberine (2.5 mg/kg), and 8) diazinon + resistance training and berberine (15 mg/kg). During 4 weeks, each groups received a certain amount of diazinon poison, berberine chloride and performed three sessions per week of resistance training. Results: In the heart tissue of diazinon-poisoned rats, resistance training had a significant (P ≤ 0.05) effect on the increased concentrations of MDA, caspase-3, 8-OHDG and GSH; 15 mg/kg of berberine consumption had a significant effect on decreased concentrations of ROS, MDA, 8-OHDG, caspase-3 and increased (P ≤ 0.05) concentrations of GSH; 2.5 mg/kg of berberine consumption had a significant (P ≤ 0.05) effect on reduced 8-OHDG. Also, 15 mg/kg of berberine consumption compared to 2.5 mg/kg of berberine consumption had a greater effect on reduced 8-OHDG. Conclusion: It seems that berberine consumption along with resistance training has interactive protective effects against oxidative stress and cell death in the heart tissue of diazinon-poisoned rats.
Full-Text [PDF 792 kb]   (1337 Downloads)    
Type of Study: Research | Subject: Pharmacology & Toxicology
Received: 2019/06/1 | Accepted: 2019/08/11 | Published: 2020/06/6

References
1. Storm JE, Rozman KK and Doull J Occupational exposure limits for 30 organophosphate pesticides based on inhibition of red blood cell acetylcholinesterase. Toxicol. 2000; 150: 1-29. [DOI:10.1016/S0300-483X(00)00219-5]
2. Abdollahi M, Mostafalou S, Pournourmohammadi S and Shadnia S. Oxidative stress and cholinesterase inhibition in saliva and plasma of rats following subchronic exposure to malathion. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacol. 2004; 137: 29-34. [DOI:10.1016/j.cca.2003.11.002]
3. McCord JM. The evolution of free radicals and oxidative stress. The American J. Medicine 2000; 108: 652-659. [DOI:10.1016/S0002-9343(00)00412-5]
4. Matés JM, Pérez-Gómez C and De Castro IN. Antioxidant enzymes and human diseases. Clinical Biochem. 1999; 32: 595-603 [DOI:10.1016/S0009-9120(99)00075-2]
5. Saulsbury MD, Heyliger SO, Wang K and Johnson DJ. Chlorpyrifos induces oxidative stress in oligodendrocyte progenitor cells. Toxicol. 2009; 259: 1-9. [DOI:10.1016/j.tox.2008.12.026]
6. Busserolles J, Zimowska W, Rock E, Rayssiguier Y and Mazur A. Rats fed a high sucrose diet have altered heart antioxidant enzyme activity and gene expression. Life Sciences 2002; 71: 1303-1312. [DOI:10.1016/S0024-3205(02)01846-5]
7. Morrison JA, Jacobsen DW, Sprecher DL, Robinson K, Khoury P and Daniels SR. Serum glutathione in adolescent males predicts parental coronary heart disease. Circulation 1999; 100: 2244-2247. [DOI:10.1161/01.CIR.100.22.2244]
8. Ghani E, Mohammadi M, Jafari M, Khoshbaten A and Asgari A. Evaluation of oxidative stress index in brain tissue of rats after expose to paraoxon. Kowsar Medical J. 2008; 13: 1-7.
9. Kaur R and Sandhu H. In vivo changes in antioxidant system and protective role of selenium in chlorpyrifos-induced subchronic toxicity in bubalus bubalis. Environmental Toxicology and Pharmacol. 2008; 26: 45-48. [DOI:10.1016/j.etap.2008.01.004]
10. Khan SM, Sobti R and Kataria L. Pesticide-induced alteration in mice hepato-oxidative status and protective effects of black tea extract. Clinica Chimica Acta 2005; 358: 131-138. [DOI:10.1016/j.cccn.2005.02.015]
11. Malekyian-Fini E, Kaviani-Nia A and Mahmoudi F. The interactive effect of aerobic training and resveratrol supplementation on C-reactive protein and metabolic profiles in women with type 2 diabetes. Feyz Journal of Kashan University of Medical Sciences 2015; 19 (5): 372-381.
12. Yamamoto K, Kondo T, Kimata A, Ueyama J, Shirotori A, Okada Y, Sakui D, Nakashima M and Yamada S. Lack of effect of aerobic physical exercise on endothelium-derived nitric oxide concentrations in healthy young subjects. Nagoya J. Medical Science 2007; 69: 167.
13. Mcbride JM and Kraemer WJ. Free Radicals, Exercise, and Antioxidants. The Journal of Strength & Conditioning Res. 1999; 13: 175-183. [DOI:10.1519/00124278-199905000-00013]
14. Radak Z, Asano K, Inoue M, Kizaki T, Oh-Ishi S, Suzuki K, Taniguchi N and Ohno H. Superoxide dismutase derivative reduces oxidative damage in skeletal muscle of rats during exhaustive exercise. J. Applied Physiol. 1995; 79: 129-135. [DOI:10.1152/jappl.1995.79.1.129]
15. Lovlin R, Cottle W, Pyke I, Kavanagh M and Belcastro A. Are indices of free radical damage related to exercise intensity. European J. Applied Physiology and Occupational Physiol. 1987; 56: 313-316. [DOI:10.1007/BF00690898]
16. Krüger K and Mooren FC. Exercise-induced leukocyte apoptosis. Exercise Immunology Review 2014; 20: 117-34.
17. Quadrilatero J, Alway SE and Dupont-Versteegden EE. Skeletal muscle apoptotic response to physical activity: potential mechanisms for protection. Applied Physiology, Nutrition and Metabolism 2011; 36: 608-617. [DOI:10.1139/h11-064]
18. Phaneuf S and Leeuwenburgh C. Apoptosis and exercise. Medicine & Science in Sports & Exercise 2001; 33: 393-396. [DOI:10.1097/00005768-200103000-00010]
19. Jafari A, Pourrazi H, Nikookheslat S and Baradaran B. Effect of exercise training on Bcl-2 and bax gene expression in the rat heart. Gene, Cell and Tissue 2015; 2 (4): e60174. [DOI:10.17795/gct-32833]
20. Kordi MR, Nekouei A, Shafiee A and Hadidi V. The effect of eight weeks high intensity aerobic continuous and interval training on gene expression of vascular endothelial growth factor in soleus muscle of healthy male rats. Arak Medical University J. 2015; 18: 53-62.
21. Zhou J, Zhou S, Tang J, Zhang K, Guang L, Huang Y, Xu Y, Ying Y, Zhang L and Li D. Protective effect of berberine on beta cells in streptozotocin-and high-carbohydrate/high-fat diet-induced diabetic rats. European J. Pharmacol. 2009; 606: 262-268. [DOI:10.1016/j.ejphar.2008.12.056]
22. Singh J and Kakkar P. Antihyperglycemic and antioxidant effect of Berberis aristata root extract and its role in regulating carbohydrate metabolism in diabetic rats. J. Ethnopharmacol. 2009; 123: 22-26. [DOI:10.1016/j.jep.2009.02.038]
23. Ju H, Li X, Zhao B, Han Z and Xin W. Scavenging effect of berbamine on active oxygen radicals in phorbol ester-stimulated human polymorphonuclear leukocytes. Biochemical Pharmacol; 1990; 39: 1673-1678. [DOI:10.1016/0006-2952(90)90110-7]
24. Margaritis I, Palazzetti S, Rousseau A-S, Richard M-J and Favier A. Antioxidant supplementation and tapering exercise improve exercise-induced antioxidant response. J. the American College of Nutrition 2003; 22: 147-156. [DOI:10.1080/07315724.2003.10719288]

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