2024-03-29T12:38:50+03:30 http://jmp.ir/browse.php?mag_id=62&slc_lang=en&sid=1
62-1006 2024-03-29 10.1002
Journal of Medicinal Plants J. Med. Plants 2717-204X 2717-2058 10.61186/jmp 2015 14 54 A Review of the Antioxidant Effects of Medicinal Plants in Athletes S Atashak Despite of many studies indicated that regular exercise training is associated with numerous health benefits for population, but determined that strenuous exercise and physical activities, through increased production of free radicals and reactive oxygen species caused oxidative stress damage and therefore decreased exercise performance in athletes. Nevertheless it has been reported that the nutritional intervention and antioxidant supplements may protect against exercise- induced oxidative stress. However because of side effects of synthetic drugs, the use of herbal medicines and natural antioxidant maybe very effective and therefore it can be recommended the supplementation of herbals to coaches and athletes. Hence in the present review, in addition to study of mechanisms of the exercise-induced oxidative stress, it has provided the effects of some antioxidant herbal supplements in sports. Exercises Medicinal plants Oxidative stress 2015 5 01 1 14 http://jmp.ir/article-1-1006-en.pdf
62-1007 2024-03-29 10.1002
Journal of Medicinal Plants J. Med. Plants 2717-204X 2717-2058 10.61186/jmp 2015 14 54 Morphophysiological and Phytochemical Responses of Dill (Anethum graveolens L.) to Foliar Application of Iron Sulfate and Zinc Sulfate H Miransari A Mehrafarin H Naghdi Badi Naghdibadi@yahoo.com Background: Foliar application of essential elements is one of the most effective methods for the supply nutritional requirements of plants and increase the quantity and quality of plants yield, especially in calcareous soils. Objective: This study was aimed to evaluate the changes in morphophysiological and pharmacological of characterestics of dill under foliar application of iron and zinc at the field conditions. Methods: This study has been conducted in the research farm of ACECR, Institute of Medicinal Plants during 2013 on the basis of factorial experiment in randomized complete block design (RCBD) with three replications. The treatments were included of iron sulfate at 4 concentrations (0, 1, 1.5 and 2 g L-1), and 3 levels of Zinc sulfate (0, 1 or 2 g L-1). Results: Application of iron and zinc sulfate had significant effect (p<0.01) on the leaf number per plant, number of lateral branches, number of inflorescences, number of umbelets per main umbel, the number of seeds per plant, shoot dry weight, essential oil content, yield of essential oil and alpha phellandrene content. In addition, all traits were significantly influenced by the iron sulphate concentrations. While, the main effect of zinc sulfate was significant only on the number of branches, shoot dry weight, alpha phellandrene content (p<0.01), and also, essential oil content, essential oil yield, and number of inflorescences (p<0.05). The highest essential oil content in the treatment of foliar application of iron and zinc sulfate at 2 g.L-1 and the maximum essential oil yield in the treatment of iron sulfate at 1.5 g.L-1 with zinc sulfate at 1 g.L-1 were obtained. Conclusion: Foliar application of integrated Iron and Zinc able to create favorable conditions for increase the quantity and quality yield of dill. Anethum graveolens L. Essential oil Iron sulfate Zinc sulfat 2015 5 01 15 29 http://jmp.ir/article-1-1007-en.pdf
62-1008 2024-03-29 10.1002
Journal of Medicinal Plants J. Med. Plants 2717-204X 2717-2058 10.61186/jmp 2015 14 54 The Study of Anti Genotoxic Effects of Saffron Aqueous Extract in Cadmium Chloride Exposed Mice Kidney by Comet Assay A Zaree HR Javadi Javadihr83@yahoo.com M Adelipor Z Hojati M Kamali H Bahadoran Background: Cadmium and its derivatives are important environmental and occupational pollutant which stored in human kidney and liver. Cadmium is known as genotoxic, carcinogenic, mutagenic and DNA damaging agents. Crocus sativus L (Saffron) is used in Traditional medicine as anti tumorogenic and anti cancer agent. Objective: The aim of this study was to evaluate the anti toxicity and anti genotoxicity effects of aqueous extracts of Crocus sativus stigmas in Swiss-Webster mice kidney. Methods: To investigate possible protective effects of saffron against chromosomal damage induced by cadmium chloride in kidney of mice, the animals randomly divided in six groups: normal, saline, saffron, saf+cad, cad+saf. Cadmium (30 µmol/kg) and aqueous extract of saffron (100mg/kg) was administered peritoneally for 3 days. Cadmium toxicity was investigated by malondialdehyd (MDA) and glutathione (GSH) concentration in liver homogenate as an indicator of lipid per oxidation and oxidative stress. DNA damage in kidney was studied using alkaline single cell electrophoresis (comet assay). Results: The results show that cadmium can induce significant cytotoxicity and genotoxicity in kidney. The DNA damage and cytotoxicity were significantly decreased in both pre and post treatment animals with aqueous extract of saffron. Moreover the results show that saffron has protective effects against oxidative stress and genotooxicity damage of cadmium. Conclusion: Therefore, use of saffron as a diet complement may be suitable for protection in industrial workers which have exposed to cadmium. Cadmium Comet assay Cytotoxicity Genotoxicity Saffron 2015 5 01 30 40 http://jmp.ir/article-1-1008-en.pdf
62-1009 2024-03-29 10.1002
Journal of Medicinal Plants J. Med. Plants 2717-204X 2717-2058 10.61186/jmp 2015 14 54 Gene Expression Involved in Sanguinarine Biosynthes is Affected by Nano Elicitors in Papaver somniferum L. M Khodayari M Omidi momidi@ut.ac.ir AA Shahnejat Booshehri D Yazdani MR Naghavi Background: Elicitors are biotic or abiotic molecules that have effectively stimulated the production of plant secondary metabolites in plant, cell and organ cultures. Objective: Opium poppy serves as one of the particular commercial source of sanguinarine, as an anticancer and antimicrobial metabolite in the pharmaceutical industryThis study was done by the aim of increasing in expression of genes involve in the synthesis ofthisvaluablemetaboliteinplantcell suspension culture. Methods: In this study, the effects of two abiotic nano elicitors (nano TiO2 and nano-Silver), were studied on the expression of genes involve in sanguinarine biosynthesis pathway (tydc7, bbe1, DIOX2 and DBOX) at different time points (6, 24, 48, 72 and 168 hours) following treatments on shoot meristem and root suspension cell cultures using Real-time PCR. Results: All of these genes were expressedmost abundantly6 and 24 hours after treatment with nano elicitors in both root and meristem suspension cell cultures. After time all the genes expression were significantly decreased. Conclusion: Comparing the results of this study with the findings of other major studies on the effect of elicitors on papaver gene expression, indicated that because of the small sizes of nano particles, they may cause the rapid induction of sanguinarine biosynthesis genes expression in the shortest possible time. Nevertheless other investigations showed the highest increasing in gene expression, 48hours after elicitation. Given that, this study was conducted on callus with dedifferentiated cells from two different organs, but remarkable distinction were observed in gene expression profile in both explant tissues. In the other words the trace of cellular memory, was seen in dedifferentiated cells regards to the origin of explants. Papaver somniferum L. Explant Gene expression Nano elicitor 2015 5 01 41 54 http://jmp.ir/article-1-1009-en.pdf
62-1010 2024-03-29 10.1002
Journal of Medicinal Plants J. Med. Plants 2717-204X 2717-2058 10.61186/jmp 2015 14 54 Ethnobotanical Study of Medicinal Plants in Zarivar Region (Marivan), Iran MA Tabad mohamadartabad@gmail.comef N Jalilian Background: Zarivar region, with about 5,000 km2 area, is located in the west of Iran, neighboaring the Marivan city. This region has a rich floral diversity due to some ecological factors such as: the average annual precipitation (about 997 mm/year), influence of the mediteranean water masses and situation within zagros mountain. Objective: The aim of this study was to identify medicinal plants flora of the Zarivar region and introducing some information of local herbal plants. Methods: Definition of the area was done based on 1:65000 topographic maps, then medicinal plant specimens were collected during years 2012-2013. Local knowledgeable people were questioned about usages of medicinal plants and data were recorded. Collected plants were deposited and identified in Herbarium of Agriculture and Natural resources research center of Kermanshah. Results: Overally 56 medicinal plant species belonging to 48 genera and 24 families were determined. Lamiaceae with 12 species and Asteraceae with 11 species had the highest species richness respectively. The most folk medicine were used for the treatment of gastrointestinal disorders. Conclusion: Results showed that numerous and valuable medicinal plants were found in Zarivar region. Traditional usage of medicinal plants is more accepted among people of the area. So, further studies may be more effective from pharmacological view of point. Botany Biodiversity Kurdistan province Medicinal plants Traditional usage 2015 5 01 55 75 http://jmp.ir/article-1-1010-en.pdf
62-1011 2024-03-29 10.1002
Journal of Medicinal Plants J. Med. Plants 2717-204X 2717-2058 10.61186/jmp 2015 14 54 Antimicrobial Effects of Kermanian Black Cumin (Bunium persicum Boiss.) Essential Oil in Gouda Cheese Matrix P Taherkhani N Noori nnoori@ut.ac.ir A Akhondzadeh Basti H Gandomi M Alimohammadi Background: Research on natural antimicrobial agents, especially of plant origin, highly noticed in recent years and evaluation of antimicrobial effects of native plants such as Iranian black cumin (zireh- siah) is especially important. Objective: In the present study, sensory characteristics and antimicrobial effects of Kermanian black cumin essential oil were investigated in Gouda cheese during ripening period. Methods: Extraction of the essential oil was performed by hidrodistillation.The oil was analyzed by GC using flame ionization (FID) and GC/ MS for detection.The antimicrobial effects were determined against various microbial groups (aerobic mesophilic bacteria, enterococci, mesophilic lactobacilli, enterobacteriaceae, lactococcus and yeasts). Microbial groupswere counted during ripening period using plate count on specific culture media. Organoleptic evaluation including teture, flavour, odor, colour and total acceptability were determined at the end of aging. Results: Accordig to results, the essential oil yield was 4/1 %(W/ W). Twenty- one compounds were identified in the oil that concluded 98.97% of the total oil.The major components of Kermanian black cumin essential oil were propanal, 2- methyl- 3- phenyl (26.05 %) and gamma- terpinene (21.86 %). Generally, the increase of Kermanian black Cumin essential oil concentration led to reduction in microbial counts in different groups.The maximum antimicrobial effect was seen in yeast that reduced by 2 log compared to the control group at EO concentration of 0.4%at day 90.The minimum reduction was observed in enterobacteriaceae that showed only 0.75 log decreese compared to the control at the same concentration of EO. Addition of EO improved organoleptic properties of Gouda cheese especially in the case of flavour and odour charactristic. However, no significant differences were observed in texture and colour between treatment and control groups. Conclusion: Kermanian black cumin essential oil could be used as preservative material and flavouring agent in some kinds of food such as cheese and also could be provided consumers health. Antimicrobial effects Gouda cheese Kermanian black cumin essential oil Sensory evaluation 2015 5 01 76 85 http://jmp.ir/article-1-1011-en.pdf
62-1012 2024-03-29 10.1002
Journal of Medicinal Plants J. Med. Plants 2717-204X 2717-2058 10.61186/jmp 2015 14 54 Changes in Seed Yield and Mucilage of Fenugreek (Trigonella foenum-graecum L.) in Response to Foliar Application of Methanol as a Bio-stimulant A Mehrafarin H Naghdi Badi Naghdibadi@yahoo.com A Qaderi MR Labbafi E Zand Gh Noormohammadi N Qavami M Seif Sahandi Background: Fenugreek is a multipurpose and valuable medicinal plant that its consumption of seeds in the pharmaceutical industry for the economically production of mucilage (galactomannan) and trigonelline is very important. Foliar application of methanol as a biostimulant on C3 plants such as the fenugreek can increase the CO2 fixation in photosynthesis and decrease photo-respiration and the result will produce more dry matter in these plants. Objective: The aim was to determine changes in seed and mucilage yield of fenugreek in response to foliar application of different concentrations of methanol. Methods: This research was carried out at the experimental farm of Medicinal Plants Institute (MPI) of Academic Center for Education, Culture & Research (ACECR) located in Karaj during two cropping seasons based on a randomized complete block design with 5 treatments and 3 replications. Foliar application during the growing season was run 3 times with 12 days interval. The treatments were control (sprayed with distilled water without methanol) and foliar application of four different concentrations of methanol (10, 20, 30 and 40 volumetric percent). Results: Foliar application of different concentrations of methanol had a significant effect on number of branches per plant, number of leaves per plant, shoot dry weight, number of pods per plant, number of seeds per pod, seed yield, yield of seed mucilage, seed ash content, seed swelling index (p≤0.01), plant height, and 1000 seeds weight (p≤0.05). Conclusion: Foliar application of methanol as a bio-stimulant and the new method in production of medicinal plants improved seed yield and yield of seed mucilage in fenugreek. In general, the maximum amounts of the studied traits were achieved in the foliar application of 40% v/v methanol concentration. Trigonella foenum-graecum L. Biostimulant Methanol Seed yield Seed mucilag 2015 5 01 86 100 http://jmp.ir/article-1-1012-en.pdf
62-1013 2024-03-29 10.1002
Journal of Medicinal Plants J. Med. Plants 2717-204X 2717-2058 10.61186/jmp 2015 14 54 Effect of Allicin on Tamoxifen-sensitive MCF-7 Breast Cancer Cells P Rahimi-Moghaddam rahimi.p@iums.ac.ir H Hashemi-Setobadi F Ghazinejhadian- Shooshtari Background: One-eighth of women will develop breast cancer in their lifetime, resulting in approximately annual one million women worldwide with breast cancer. Approximately 70% of breast cancers are positive for estrogen receptor alpha (ER-). The presence of ER- receptor is associated with better prognosis and usually indicates that the anti-estrogen drugs such as tamoxifen can be useful in the treatment. Nevertheless, a significant number of ER--positive breast cancers does not respond to tamoxifen. Causes of resistance to tamoxifen and how to sensitize to tamoxifenis not yet known. Preliminary studies indicate that garlic and its derivatives such as allicin, have anti-cancer effects. Objective: This study aims to investigate the inhibitory effect of allicin on tamoxifen-sensitive MCF-7 cells. Methods: To investigate this theory, the effect of allicin on tamoxifen-sensitive cells (MCF-7), and -resistant cells (Sk-Br-3) in the presence and absence of tamoxifen and 17- estradiol were studied. The cell viability was assessed using MTT assay at 24, 48 and 72 hours. Results: The study revealed that allicin in MCF-7 cells enhances the effectiveness of tamoxifen in the presence and absence of 17-b estradiol. Conclusions: Allicin as an adjunct to tamoxifen can sensitize breast cancer cells to tamoxifen. Allicin Breast cancer cell line MCF-7 Garlic Tamoxifen 2015 5 01 101 110 http://jmp.ir/article-1-1013-en.pdf
62-1014 2024-03-29 10.1002
Journal of Medicinal Plants J. Med. Plants 2717-204X 2717-2058 10.61186/jmp 2015 14 54 The Methyl Jasmonat Elicitaion and Taxol Production in Corylus avellana L., under Invitro Culture Condition Ch Ebrahimi M Solouki M Omidi M Forootan AR Zare A Mehrafarin A Qaderi Ardeshir582008@gmail.com Background: Hazelnut (Corylus avellana) is a species belonging to the genus Corylus. Its various segments contain different metabolites with very valuable medicinal, anti-microbial and anti-cancer properties. Objective: The present study was done to investigation the optimal conditions for hazelnut plants regenerated from cotyledon as explants and invitrotaxol production. Methods: Cotyledon segments were cultured on MS medium containing 2,4-D concentrations of 0, 0.5 and 1 mgl-1 alone or in combination with concentrations of 0, 0.5 and mgl-1 BA for callus induction. For regeneration, Calli were sub-cultured to the same medium and or transferred to the MS medium containing BA at concentrations of 0, 0.25, 0.5, 1, 2 and 3 mgl-1 Callus was formed in all hormonal treatments. The ability of taxol production in calli was evaluated by adding methyl jasmonat in 0, 10, 40, 70, 100, 130 and 160 µM concentrations. Results: In hormonal treatment including 0.5 mgl-1 2.4-D regeneration was observed. The highest Taxol content (16.7 mg/KgDW) was obtained by adding 130 µM methyl jasmoante against of 4.3 mg/KgDW in control condition. In regenerative treatments maximum number of regenerated shoot (2.5) was in 1 mgl-1 BA. The regenerated shoots were rooted in MS medium containing 2 mg NAA in combination with 0.5 mgl-1 BA. After rooting process, the plantlets with suitable growth (10 cm length) were planted in the mixture of perlite: peat: cocopit in a 1:2:1 ratio and than were placed in a box with a humidity of 90%. The adapted plants were transferred to greenhouse after 4 weeks. Conclusion: This study can be applied as an effective method for callus induction in order to establishment of suspension culture to taxol production and also results can be useful for regeneration of transgenic calli. Corylus avellana L. Callus induction Regeneration Taxol production 2015 5 01 111 121 http://jmp.ir/article-1-1014-en.pdf
62-1015 2024-03-29 10.1002
Journal of Medicinal Plants J. Med. Plants 2717-204X 2717-2058 10.61186/jmp 2015 14 54 Skeletal Muscle Relaxant Effects of Thymoquinone, the Major Constituent of Nigella sativa S Parvardeh parvardehs@sbmu.ac.ir M Moghimi Background: It has been shown that Nigella sativa seeds has several pharmacological activities such as sedative effects, decrease in locomotor activity and muscle relaxation. As, many therapeutic properties of Nigella sativa is attributed to its major constituent, “thymoquinone”, it might be proposed that Nigella sativa effects on locomotor activity and muscle relaxation is attributed to thymoquinone. Objective: In this study, the effect of thymoquinone on the contractile responses of skeletal muscle has been investigated, using experimental methods. Methods: The chick biventercervicis nerve-muscle preparation was isolated and placed in organ bath. Then, the effects of thymoquinone on contractile responses of skeletal muscle evoked by acetylcholine, KCl, and electrical field stimulation were evaluated through tension recording protocols. Also, muscular strength and motor coordination of mice were evaluated in vivo using traction test and rotarod apparatus following intraperitoneal injection of various doses of thymoquinone. Results: Thymoquinone (40, 80, 100 M) significantly inhibited contractile responses of skeletal muscle to acetylcholine (100 M) and electrical field stimulation, but could not affect contractions induced by KCl (80 mM). Also, thymoquinone (40, 80 mg/kg) significantly decreased the maintenance time of animals in the traction test and rotarod apparatus. Conclusion: The results indicate that thymoquinone may act as a muscle relaxant agent and inhibits the skeletal muscle spasms. Nigella sativa Acetylcholine Muscle relaxation Tension recording Thymoquinone 2015 5 01 122 133 http://jmp.ir/article-1-1015-en.pdf
62-1016 2024-03-29 10.1002
Journal of Medicinal Plants J. Med. Plants 2717-204X 2717-2058 10.61186/jmp 2015 14 54 Inhibition of Hemolysis of Red Blood Cells by Citrullus colocynthis, Ilex spinigera and Gleditsia caspica Extracts M Mohadjerani m.mohajerani@umz.ac.ir M Damanjany Background: Many plants chemical substances that possess antioxidant properties, were known that might have an antihemolytic effect on erythrocytes. The use of synthetic antioxidants however, has been limited because of their toxicity and side effects. Therefore, medical researchers have intensified their quest to find natural antioxidants. Objective: The effect of extract of leaf and pulp of Citrullus colocynthis, leaf of Ilex spinigera and leaf and fruit of Gleditsia caspica as medicinal plants were investigated on red blood cell hemolysis. Methods: The plants were extracted in MeOH as solvent by soxhlet apparatus. Blood samples were collected from health volunteers and divided into two groups: test and control. Red blood cell peroxidation for each extract (5 - 150 µg/ml) was induced using AAPH (2, 2´-azo-bis-(2-amidinopropane) dihydrochloride) (35 mM). Percentage of hemolysis was measured spectrophotometrically by reading the absorbance at 540 nm as released hemoglobin from the cell in the presence and absence of the extracts. Results: Leaf extract of Gleditsia caspica with IC50: 5.58 ± 0.03 µg/ml and Ilex spinigera with IC50: 13.85 ± 0.02 µg/ml showed the higher inhibitory effect on hemolysis among other extracts. Conclusion: The results show that the use of the plants, Gleditsia caspica and Ilex spinigera, as natural antioxidants in the prevention and treatment of many diseases, including hemolysis of red blood cells by oxidizing agents can be studied. Citrullus colocynthis Gleditsia caspica Ilex spinigera AAPH Antihemolysis 2015 5 01 134 145 http://jmp.ir/article-1-1016-en.pdf
62-1017 2024-03-29 10.1002
Journal of Medicinal Plants J. Med. Plants 2717-204X 2717-2058 10.61186/jmp 2015 14 54 Responses of Quality and Quantity Yield of Garden Thyme (Thymus vulgaris L.) to Foliar Application of Bio-stimulator Based on Amino Acids and Methanol H Naghdi Badi MR Labbafi N Qavami A Qaderi V Abdossi MR Agharebparast A Mehrafarin A.Mehrafarin@gmail.com Background: Now, the use of amino acids and methanol as a plant biostimulant is very interested for the increased secondary metabolites in medicinal plants. Objective: The aim was to evaluate the effect of biostimulants and methanol on the content and components of essential oil and morphological traits of thyme (Thymus vulgaris L.). Methods: This experiment was conducted on the basis of randomized complete block design with nine treatments and three replications. The treatments of this study included foliar application of kadostim, fosnutren, humiforte, and aminolforte, each of them with two levels of methanol aqueous solution at 10 and 20 %v/v, and control treatment (without application of plant biostimulants and methanol). Results: The results showed that were statistically significant the number of branches, stem diameter, shoot dry weight, thymol and carvacrol content at the 1% level, and the number of leaves per stem, plant height, essential oil content, and leaf dry weight at the 5% level. The maximum plant height, number of branches, number of leaves per stem, stem dry weight, leaf dry weight, and shoot dry weight in treatment of kadostim with 20% methanol, and the highest stem diameter, essential oil content, thymol, and carvacrol content in treatment of humiforte with 20% methanol were obtained. Conclusion: Application of kadostim and humiforte with 20% methanol enhanced the quantitative and qualitative yield of thyme. Therefore, the integrated application of biostimulants and methanol can be synchronized with reduce the use of some chemical fertilizers to the extent that it was leading to sustainable agriculture and reduction of environmental pollution. Thymus vulgaris L. Essential oil Amino acids Thymol Carvacrol 2015 5 01 146 158 http://jmp.ir/article-1-1017-en.pdf
62-1018 2024-03-29 10.1002
Journal of Medicinal Plants J. Med. Plants 2717-204X 2717-2058 10.61186/jmp 2015 14 54 A Comparative Study of the Effects of Cumin and Mefenamic Acid Capsules on Menstrual Bleeding in IUD Users: A Randomized Triple Blind Clinical Trial M Rajabi Naeeni M Modarres Ma_modars@yahoo.com GH Amin N Bahrani Background: Unusual menstrual bleeding is one of the most common side effects of IUD. Objective: Considering public enthusiasm to the use of herbal medicine, this study conducted to compare the effects of cumin and mefenamic acid capsules on menstrual bleeding in IUD users. Methods: This crossover triple-blind randomized clnical trial study was performed on 100 IUD users who came to 6 health centers in Karaj. Research took place in three stages. In the first stage menstrual bleeding was measured by using Hygam table. In the second stage all participants were randomly allocated to mefenamic acid and cumin groups. They took capsules for two consecutive cycle. In the third stage each research unit received the same treatment of the opposite group with replacing the medicine for two more consecutive cycle. Menstrual bleeding was assessed by using Hygam table for 5 cycle. Considering that the maximum efficacy time for cumin was 24 hours and for Mefenamic acid was6 to 8 hours, the use of drugs in 7 days during menstruation, had no effect on subsequent cycles. Data, was analyse by Chi-square and Fisher's exact test, paired t-test, Wilcoxon. Results: The mean of menstrual bleeding was 154.26±60.08 and after treatment was 106.68±45.38 and 105.8±40.56 in the mefenamic acid and cumin groups. There was a significant difference in decrease of pain intensity in both groups (p<0.001). There wasn’t a significant difference in decrease of pain intensity between two groups. Conclusion: This study showed that cumin same as mefenamic acid capsules can decrease menstrual bleeding effectively. Therefore it is recommended to use it in the treatment of menstrual bleeding in IUD users. Cumminum cyminum IUD Mefenamic acid Menstrual bleeding 2015 5 01 159 168 http://jmp.ir/article-1-1018-en.pdf
62-1019 2024-03-29 10.1002
Journal of Medicinal Plants J. Med. Plants 2717-204X 2717-2058 10.61186/jmp 2015 14 54 Neuroprotective Effect of Mentha longifolia L. Extract on Ischemia/reperfusion-induced Brain Injury in Male Wistar Rats F Fathi farhadfathi.370@gmail.com SH Oryan M Rafieian A Eidi Background: Recent studies have suggested that Mentha longifolia L. extracts (ME) have antioxidant activities. Objective: In this paper, attempts were made to determine the effect of MEin rat stroke model. Methods: Five groups (n=14) were studied the first and second groups (control and sham) received intraperitoneal injection with daily distilled water. The other three groups received 50, 100 and 200 mg/kg/day of the ME for 21 days. Two hours after the last dose, each main group was subdivided into middle cerebral artery occlusion (MCAO) operated for infarct volume assessment and intact subgroup for the assessment of brain and serum antioxidant activity and lipid proxidation of brain and serum, respectively. Results: Pretreatment with ME resulted in a significant reduction in total infarct volume. ME significantly increased antioxidant activity in penumbra and core in comparation with the control. The antioxidant activity of serum in the 100 mg/kg/day group was significantly higher than that of the control group. Malondialdeyde (MDA) level in the penumbra area was significantly elevated in the control group in comparison with other pretreated groups. ME at dose of 100 mg/kg significantly decreased MDA level in core area scale to the control. Moreover, ME with the doses of 100 and 200 mg/kg/day reduced MDA level of serum. Conclusion: ME may protect ischemia/reperfusion induced brain injury by increase in antioxidant activity, decrease in lipid proxidation and reduction in infarction volume. Antioxidant activity Cerebral ischemia Lipid peroxidation Mentha longifolia L. extract Reperfusion 2015 5 01 169 182 http://jmp.ir/article-1-1019-en.pdf
62-1020 2024-03-29 10.1002
Journal of Medicinal Plants J. Med. Plants 2717-204X 2717-2058 10.61186/jmp 2015 14 54 Consumption of Ginkgo biloba Extract and Swimming Training on NMDA and BDNF Plasma in Untrained Girls B Hajirezaii A Barari alireza54.barari@gmail.com A Abbassi Daloii Background: Ginko biloba stimulate blood circulation to the brain. As a result of insufficiency to improve blood flow to the brain. Objective: The aim of this study was to investigate the effect of eight weeks endurance training swimming on BDNF and NMDA levels with Ginkgo biloba extract young girls untrained. Methods: 40 healthy females aged 27-22 girls as subjects of this study were selected and randomly divided into four groups of 10 people (1-swim training with Ginkgo biloba extract (SG), 2- swimming training(S), 3- Ginkgo biloba extract (G) and 4- control group (C)). The aqueous extract of Ginkgo biloba with amount of 80mg/day and were prescribe for eight weeks. The experimental group consisted of eight-week training program three times a week, with an intensity of 60-75% of maximum heart rate were performed. Blood samples from subjects 24 hours before and after the test, was used for measure the levels of NMDA and BDNF. Results with the t-test and one-way analysis of variance were analyzed and significant levels of p ≤0.05 determined. Results: The results showed that levels of NMDA in SG and G group had significant increase. However, The significant increase in the levels of BDNF in SG, G and S were observed. Conclusion: The present study endurance training and Ginkgo biloba consumption was effective in decrease anxiety and improve memory that related to flavonoid and antioxidant activity of this plant. Ginkgo biloba BDNF NMDA Swiming training 2015 5 01 183 190 http://jmp.ir/article-1-1020-en.pdf