Institute of Medicinal Plants, ACECR
Journal of Medicinal Plants
2717-204X
2717-2058
1
1
2002
3
1
Antihypoxic, anti-ischemic and acute toxicity effect of Salvia leriifolia Benth. root in mice and rats
1
10
FA
Hossein
Hosseinzadeh
Pharmaceutical Sciences Rescarch Center and School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
hosseinzadehh@yahoo.com
Y
Alireza
Khoei
School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
N
Mahmoodreza
Jafari
Bu-Ali Research Institute and School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
N
Javad
Ghasamipour
Pharmacist
N
The antihypoxic effect Salvia leriifolia root aqueous and ethanolic extracts was studied using hypoxia creating in a tightly glass container in mice. Ischemia was induced using four-vessel occlusion model and evaluated by optical and transmission electrinic microscope in rats. The extract of S. leriifolia showed antihypoxic effect and the minimum effective dose was 0.7 g/kg. In ischemic rat, the aqueous and ethanolic extracts significantly reduced neural cell injury in CA1 and CA3, 4 hippocampus rats. LD50 values (i.p, mice) of the aqueous and the ethanolic extracts were 1.45 g/kg and 1.55 g/kg, respectively. Both extracts comprised saponins and tannins. These results indincate that the extracts of S. leriifolia root have protective effect against hypoxia and ischemia.
Salvia leriifolia, Antihypoxic activity, Anti-ischemic activity, Hippocampus
http://jmp.ir/article-1-816-en.html
http://jmp.ir/article-1-816-en.pdf
Institute of Medicinal Plants, ACECR
Journal of Medicinal Plants
2717-204X
2717-2058
1
1
2002
3
1
Study on the effect of some pure plant volatile oils on the affinity of native and oxidized LDL to its receptor on the adrenal cells
11
18
FA
Gholamali
Naderi
Isfahan Cardiovascular Research Center. Isfahan University of Medical Sciences, Isfahan, Iran
Isfcarvasrc@hotmail.com
Y
Sedigheh
Asgary
Isfahan Cardiovascular Research Center. Isfahan University of Medical Sciences, Isfahan, Iran
N
Mohsen
Ani
Faculty of Pharmarcy, Isfahan University of Medical Sciences, Isfahan, Iran
N
Nazal
Sarrafzadegan
Department of Cardiology, Isfahan University of Medical Sciences, Isfahan, Iran
N
Mahmoodreza
Safary
Hamedan University of Medical Sciences, Hamedan, Iran
N
Accumulating evidence shows high plasma levels and preoxidation of LDL display the key role in atherogenesis. When LDL is oxidized, the affinity of LDL to its receptor is decreased and via scavenger receptor on macrophages is being taken off. The resultant accumulation of ox-LDL in macrophages leads to the appearance of foam cells and fatty streak formation in the subendothelial cells of arterial wall. In this study, antioxidant properties of eight natural volatile oils include: Geraniol, Thymol, Pulegone, P-cymol, Linalool, Limonene, Eugenol, Anethol and its effect on the affinity of native and oxidized-LDL to its receptor in bovine adrenal cells have been investigated in the presence of fluoresein isothiocyanate-labled-LDL. The results show that between volatile oils used in the study Eugenol and Thymol are the best compounds that were increased the affinity of native and oxidized LDL to its adrenal cells receptor. The effect of these compound on oxidized LDL is Thymol> Eugenol> Geraniol> Limonene> P-Cymol> Linalool> Anethol> Pulegone. And on native LDL is Eugenol> Thymol> Linalool> P-Cymol> Limonene> Geraniol> Pulegone> Anethol. These results indicate that, volatile oils especially Thymol and Eugenol have antioxidant properties and probably via its lipophylic effect and effect on the LDL particles changed the affinity of LDL for its receptor. However, deeper and more studies are warranted to use such compounds for clinical usages especially atherosclerosis and cholesterol reduction.
LDL, Receptor, Oxidation, Atherosclerosis, Volatile oils
http://jmp.ir/article-1-817-en.html
http://jmp.ir/article-1-817-en.pdf
Institute of Medicinal Plants, ACECR
Journal of Medicinal Plants
2717-204X
2717-2058
1
1
2002
3
1
Ginger (Zingiber officinale Roscoe)
19
28
FA
Masoud
Kavoli Haghighi
Institute of Medicinal Plants, Jehad-e-Daneshgahi, Tehran, Iran
Y
Tayebeh
Tooliat
Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
N
The article has been reviewed history, monograph, active chemical constituents, dosage forms, action mechanisms, clinical trial studies, side effects, drug Interaction, and precautions of ginger. The large review has been made by available manuscripts in internet, periodical magazines, and the newest published books. Ginger is a medicinal herb that used in treatment of some of diseases, including nausea, vomiting, rhomatoid artheritis and osteoarthritis. However, clinical studies supporting its value for treatment of diseases are lacking.
Zingiber officinale, Ginger, Alternative medicine, Osteoarthritis, Antivometic, Antica
http://jmp.ir/article-1-818-en.html
http://jmp.ir/article-1-818-en.pdf
Institute of Medicinal Plants, ACECR
Journal of Medicinal Plants
2717-204X
2717-2058
1
1
2002
3
1
Passionflower in the treatment of generalized anxiety disorder: a double-blind and randomized trial with oxazepam
29
38
FA
Mohsen
Vaziran
Roozbeh Psychiatric Hospital, Tehran University of Medical Sciences, Tehran, Iran
vazirian_mohsen@yahoo.com
Y
Azin
Khazaeli
Roozbeh Psychiatric Hospital, Tehran University of Medical Sciences, Iran
N
Hamidreza
Naghavi
Roozbeh Psychiatric Hospital, Tehran University of Medical Sciences, Iran
N
Shahin
Akhondzadeh
Institute of Medicinal Plants, Jehad-e-Daneshgahe, Tehran, Iran
N
Passionflower (Passiflora incarnata) is folk remedy for anxiety. A double-blind randomized trial compared the efficacy of Pascinora incarnata extract with oxazepam in the treatment of generalized anxiety disorder. The study was performed on 36 patients. They were outpatients and had been diagnosed with generalized anxiety disorder (GAD) using DSM-IV criteria. Patients were allocated in a random fashion 18 to Passiflora extract 45 drops/day plus placebo tablet and 18 to oxazepam 30 mg/day plus placebo drops for a 4-weck trial. Passiflore extract and oxazepam were effective in the treatment of generalized anxiety disorder. No significant difference was observed between the two protocols at the end of trial. Oxazepam showed a rapid onset of action. On the other hand, significantly more problems relating to impairment of job performance was encountered with subjects on oxazepam, We concluded that passiflora extract is an effective drug for the management of generalized anxiety disorer and the incidence of impairment of job performance with passiflora extract compared to oxazepam is an advantage.
Passionflower, GAD, Oxazepam
http://jmp.ir/article-1-819-en.html
http://jmp.ir/article-1-819-en.pdf
Institute of Medicinal Plants, ACECR
Journal of Medicinal Plants
2717-204X
2717-2058
1
1
2002
3
1
The composition of the essential oil of Artemisia annua L. growing wild in Iran
39
46
FA
Hossein
Lari yazdi
Eslamic AZAD University, Brodjerd, Iran
Y
Ramezanali
Khavarinejad
Tarbiat Moalem University, Tehran, Iran
N
Abdolhossein
Roustaian
Research and Sciences Institute, Azad-e-Eslami University, Tehran, Iran
N
The composition of essential oil of the leaves of Artemisia annua L. growing wild in Iran, were determined by the use of GC/MS. The leaf essential oils obtained by hydrodistilation. Predominantly comprised monoterpenids and the main constituents were α-Pinene (7.8713.28%), 1,8-Cineole (5.77-17.26%), Artemisia ketone (1.44-6.97%), Camphor (14.2629.05%) and Pinocarvone (3.64-8.04%). The principal sesquiterpenes were β-Caryphyllen (3.43-9.37%), Germacrene-D (3.07-6.26%) and β-Selinene (0.46-10.36%).
Artemisia annua, Essential oil, Monoterpene, Sesquiterpene
http://jmp.ir/article-1-820-en.html
http://jmp.ir/article-1-820-en.pdf
Institute of Medicinal Plants, ACECR
Journal of Medicinal Plants
2717-204X
2717-2058
1
1
2002
3
1
Grapefruit juice effects
47
62
FA
Bita
Mesgarpour
National Research Center of Medical Sciences, Tehran, Iran
mesgarpur@nrcms.org
Y
Hamidreza
Adhami
Researcher
N
Masoud
Amanlou
Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Iran
N
Grapefruit juice is used as a nutritional supplement for potassium loss. Grapefruit pectin can reduce cholesterol and promote regression of atherosclerosis. Other effects include induction of red cell aggregation, reduction of hematocrits and possible anti-cancer effects. One glass of grapefruit juice or half of a grapefruit can significantly increase the absorption as well as decrease the metabolism (inactivation) of many commonly used oral medications. The interaction between some drugs and grapefruit juice is called the "grapefruit juice effect". The result is that greater amounts of the affected drugs enter the bloodstream, and these drugs can have increased therapeutic effects or increased toxicity. The mechanism of the grapefruit juice effect is probably that one or more of the chemicals (most likely bioflavonoids and/or furanocoumarins) in grapefruit juice inhibit the cytochrome P450 isoenzymes, especially 3A4 isoenzyme. Hence, any drug normally metabolized by that enzyme may show increased effectiveness and/or toxicity when taken with grapefruit juice. This review discusses about clinical trials of drugs that their effects are potentiated by grapefruit juice include some antihistamines, benzodiazepines, calcium channel blockers. cholesterol lowering statins, immunosuppressants and others.
Grapefruit juice, Cytochrome P450, Drug interactions
http://jmp.ir/article-1-821-en.html
http://jmp.ir/article-1-821-en.pdf
Institute of Medicinal Plants, ACECR
Journal of Medicinal Plants
2717-204X
2717-2058
1
1
2002
3
1
Passionflower in the treatment of opiates withdrawal: a double blind and randomized controled trial
63
68
FA
Department of Psychatric, Mazandaran University, Sari, Iran
sepideh@ravan.com
Y
Seyed Hamzeh
Hosseini
Department of Psychatric, Mazandaran University, Sari, Iran
N
Azin
Khazaeli
Roozbeh Psychatric Hospital, University of Medical Sciences, Tehran Iran
N
Mousa
Khani
Institute of Medicinal Plants, Jehad-e-Daneshgahi, Tehran, Iran
N
Shahin
Akhondzadeh
Institute of Medicinal Plants, Jehad-e-Daneshgahi, Tehran, Iran
N
Clonidine-base detoxification has been utilized as the main protocol for several years However, detoxification with clondine has its limitation, including lack of efficacy for mental symptoms. Accumulating evidence shows the efficacy of Passifloru incurnata extract in management of anxiety. In our continuing study of traditional medicines, which have neurotropic effects, the use of this plant reported an anxiolytic effect, which can be evaluated as an adjuvant agent in the detoxification of opiates by clonidine. We presented the results from a double-blind randomized controlled trial of clonidine plus passiflora extracts vs., clonidine plus placebo drop in the outpatient detoxification of 65 opiates addicts. A total of 65 opiates addicts were randomly assigned to treatment with passiflora extract plus clonidine tablet or clonidine tablet plus placebo drop during a 14 days, double-blind clinical trial. All patients met the DSM-IV criteria for opioid dependence. The fixed daily dose was 60 drops for passiflora extract and the maximum daily dose for clonidine was 0.8 mg. This trial medication was given three times per day in divided doses. The severity of the opiate withdrawal syndrom was measured in days 0.1.2.3.4.7 and 14 using SOWS (Short Opiate Withdrawal Scale). Both protocols were equally effective in treating the physical symptoms of withdrawal syndrom. However, passionflower plus clonidine group showed a significant superiority over the clonidine alone in the management of mental symptoms. These results suggested that passiflora extract may be an effective adjuvant agent in the management of opiate withdrawal. However, a larger study to confirm our results is warranted.
Clonidine, Detoxification. Opiate withdrawal. Passionflower
http://jmp.ir/article-1-822-en.html
http://jmp.ir/article-1-822-en.pdf
Institute of Medicinal Plants, ACECR
Journal of Medicinal Plants
2717-204X
2717-2058
1
1
2002
3
1
Antioxidant effect of the essential oil and extract of Matricaria chamomilla L. on isolated rat hepatocytes
69
76
FA
Sedigheh
Asgary
Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
Isfcarvasrc@hotmail.com
Y
Gholamali
Naderi
Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
N
Nasrollah
Bashardoost
Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
N
Zohreh
Etminan
Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
N
Free radicals are active molecules that are present every where and may be of internal or external origin. One of the most important destructive effects of free radicals is promoting lipid peroxidation resulting membrane destruction. This process causes the destruction of membrane and changing activities of intra membrane enzymics and other proteins and releasing radicals that is initially harmful to cells. In this study essential oil and extract of Matricuria chamonilla and pure essential oil (Azulone) are emphasised to be studied as antioxidants and free radical scavenger. Tershio Butyl Hydroperoxide (t-BIT) was used because of its capability to produce lipid peroxidation. Varied compounds were used in three concentrations. The produced malondialdehyde (MDA) was measured by the spectrophotometrie at 535 mm. Also, the enzymatic activities of LDH and AST were measured. Thenc enzymes are as markers for determining lipid peroxidation levels and decreasing their activity indicate the inhibitoty power of the treated compound. The highest level for inhibition of MDA production were respectively Matricaria chamomilla (essential oil) (58%)> azulene (35.4%) > Matricaria chamomilla (extract) (16%). There is a direct relationship between MDA level with enzymatic activities of LDH and AST. Results indicate the antioxidant effect of Matricaria chomomilla. Surely, it is required to wide spread in vivo study on these compounds to determine side effects and appropriate doses for the best efficacy and clinical usages.
Antioxidant, Matricaria chamomilla, Free radicals, Lipid peroxidation, Hepatocytes
http://jmp.ir/article-1-823-en.html
http://jmp.ir/article-1-823-en.pdf