en
jalali
1388
6
1
gregorian
2009
9
1
8
31
online
1
fulltext
fa
A Review on Medicinal Plants Used in Animal Models and Clinical Trials concerning Drug Addiction
A Review on Medicinal Plants Used in Animal Models and Clinical Trials concerning Drug Addiction
Addiction to drugs, such as heroin, cocaine and alcohol, exacts great human and financial costs on society. Various evidence-based pharmacological and psychosocial interventions are currently used in the treatment of drug addiction but they do not produce adequate therapeutic benefits in every patient. Further, barriers such as financial cost, lack of availability, or perceptions of existing treatments as unappealing may limit rates of treatment uptake. Thus developing new treatments may attract a larger number of drug addicts into treatment. The use of herbal medicines within a pluralistic treatment model fits well within a range of existing theoretical frameworks for treating drug dependence. Here, the effects of Hypericum perforatum, Valeriana officinalis, Passiflora incarnata, Rosmarinus officinalis, Papaver rhoea, Tabernanthe iboga, Ginkgo biloba, salvia miltiorrhiza, Pueraria lobata, Opuntia ficus-indica, Cynara scolymus, Panax ginseng, melatonin, ibogaine and its derivative 18-methoxycoronaridine and some other plants active constituents in animal models and clinical trials concerning drug dependence as well as alcohol intake and hangover are reviewed. At this stage, there remains insufficient evidence to support the use of medicinal plants or their active constituents as a primary intervention for pharmacotherapy of drug addiction. Further clinical trials are required to clarify the potential role of particular agents.
Addiction to drugs, such as heroin, cocaine and alcohol, exacts great human and financial costs on society. Various evidence-based pharmacological and psychosocial interventions are currently used in the treatment of drug addiction but they do not produce adequate therapeutic benefits in every patient. Further, barriers such as financial cost, lack of availability, or perceptions of existing treatments as unappealing may limit rates of treatment uptake. Thus developing new treatments may attract a larger number of drug addicts into treatment. The use of herbal medicines within a pluralistic treatment model fits well within a range of existing theoretical frameworks for treating drug dependence. Here, the effects of Hypericum perforatum, Valeriana officinalis, Passiflora incarnata, Rosmarinus officinalis, Papaver rhoea, Tabernanthe iboga, Ginkgo biloba, salvia miltiorrhiza, Pueraria lobata, Opuntia ficus-indica, Cynara scolymus, Panax ginseng, melatonin, ibogaine and its derivative 18-methoxycoronaridine and some other plants active constituents in animal models and clinical trials concerning drug dependence as well as alcohol intake and hangover are reviewed. At this stage, there remains insufficient evidence to support the use of medicinal plants or their active constituents as a primary intervention for pharmacotherapy of drug addiction. Further clinical trials are required to clarify the potential role of particular agents.
Medicinal plants, Drug addiction, Alcohol intake, Alcohol hangover
Medicinal plants, Drug addiction, Alcohol intake, Alcohol hangover
1
13
http://jmp.ir/browse.php?a_code=A-10-71-10&slc_lang=en&sid=1
2009/05/5
1388/2/15
2009/07/4
1388/4/13
S
Kianbakht
Department of Pharmacology and Applied Medicine, Institute of Medicinal Plants, ACECR
S
Kianbakht
skianbakht@yahoo.com
00319475328460038244
00319475328460038244
Yes
Department of Pharmacology and Applied Medicine, Institute of Medicinal Plants, ACECR
en
Antimicrobial Activity of Lactobacillus plantarum Strains Isolated from Fermented Olives Origin
Antimicrobial Activity of Lactobacillus plantarum Strains Isolated from Fermented Olives Origin
Background: Lactobacillus plantarum isolated from fermented olives has been extensively studied with the aim of its use in starter cultures for olive or other production fermentations, but little is known about its antimicrobial resistance and its probiotic effects. Objectives: The aim of this study was to determine the antimicrobial activity using different strains of L. plantarum isolated from fermented olives origin against Salmonella typhimurium. Methods: Three strains of L. plantarum were isolated from fermented green olives (Lp1,Lp2,Lp3).they were grown in MRS broth at 37o C. Overnight culture of S. typhimurium was added to MRS broth containing 108 CFU/mL of L. plantarum. Reduction of the viable cells was assayed on bismuth sulfit agar medium for 24h. Antimicrobial activities of L. plantarum cells against the test strain of Salmonella were also determined by measuring the diameter of growth inhibition zone in agar spot test. Results: All of the L. plantarum strains could inhibit growth of S. typhimurium. Also visible inhibition zones were observed around the spotted cells of L. plantarum strains in the spot tests. Conclusion: Results showed great inhibitory effect of the L. plantarum strains against Salmonella and were differed in their antimicrobial activities which could be due to the metabolite secreted by the L. plantarum strains specially type of bacteriocins.
Background: Lactobacillus plantarum isolated from fermented olives has been extensively studied with the aim of its use in starter cultures for olive or other production fermentations, but little is known about its antimicrobial resistance and its probiotic effects. Objectives: The aim of this study was to determine the antimicrobial activity using different strains of L. plantarum isolated from fermented olives origin against Salmonella typhimurium. Methods: Three strains of L. plantarum were isolated from fermented green olives (Lp1,Lp2,Lp3).they were grown in MRS broth at 37o C. Overnight culture of S. typhimurium was added to MRS broth containing 108 CFU/mL of L. plantarum. Reduction of the viable cells was assayed on bismuth sulfit agar medium for 24h. Antimicrobial activities of L. plantarum cells against the test strain of Salmonella were also determined by measuring the diameter of growth inhibition zone in agar spot test. Results: All of the L. plantarum strains could inhibit growth of S. typhimurium. Also visible inhibition zones were observed around the spotted cells of L. plantarum strains in the spot tests. Conclusion: Results showed great inhibitory effect of the L. plantarum strains against Salmonella and were differed in their antimicrobial activities which could be due to the metabolite secreted by the L. plantarum strains specially type of bacteriocins.
;lt,i;gt,Lactobacillus plantarum;lt,/i;gt,, Olives origin, Antimicrobial activity, Salmonella typhimurium
;lt,i;gt,Lactobacillus plantarum;lt,/i;gt,, Olives origin, Antimicrobial activity, Salmonella typhimurium
14
18
http://jmp.ir/browse.php?a_code=A-10-234-1&slc_lang=en&sid=1
2009/05/52009/05/11
1388/2/21
2009/07/42009/06/27
1388/4/6
MR
Fazeli
Department of Microbiology, Drag and Food Control Department, School of Pharmacy, Tehran University of Medical Sciences
MR
Fazeli
00319475328460038245
00319475328460038245
No
Department of Microbiology, Drag and Food Control Department, School of Pharmacy, Tehran University of Medical Sciences
E
Vaghari
Department of Microbiology, Drag and Food Control Department, School of Pharmacy, Tehran University of Medical Sciences
E
Vaghari
Vaghari_el@yahoo.com
00319475328460038246
00319475328460038246
Yes
Department of Microbiology, Drag and Food Control Department, School of Pharmacy, Tehran University of Medical Sciences
H
Jamalifar
Department of Microbiology, Drag and Food Control Department, School of Pharmacy, Tehran University of Medical Sciences
H
Jamalifar
00319475328460038247
00319475328460038247
No
Department of Microbiology, Drag and Food Control Department, School of Pharmacy, Tehran University of Medical Sciences
Z
Ebrahim
Department of Pharmacy, Tehran University of Medical Sciences
Ebrahim
00319475328460038248
00319475328460038248
No
Department of Pharmacy, Tehran University of Medical Sciences
N
Samadi
Department of Pharmacy, Drag and Food Control Department, School of Pharmacy, Tehran University of Medical Sciences
N
Samadi
00319475328460038249
00319475328460038249
No
Department of Pharmacy, Drag and Food Control Department, School of Pharmacy, Tehran University of Medical Sciences
en
Fingerprint Study of Thymus spp. by TLC
Fingerprint Study of Thymus spp. by TLC
Background: Thymus is a widely used medicinal plant in food and pharmaceutical industries. Among different species of Thymus, T. vulgaris is used more than other species in therapeutic dosage forms. Objective: This study was conducted to differentiate various Thymus species by TLC fingerprint. Methods: In order to identify and differentiate various species of Thymus, TLC fingerprints of essential oil, dichloromethane, ethylacetate and n-butanol extracts of four available species named T. vulgaris, T. pubescens, T. citriodorus and T. daenensis were obtained and compared with each other. Results: The results showed that the TLC chromatograms of essential oil and n-butanol extract can not be used as differential identification for the above-mentioned species while the ethylacetate and dichloromethane extracts are more reliable to be used for TLC fingerprints. TLC chromatogram of ethylacetate extract is specific for identification of T. pubescens and T. vulgaris while T. citriodorus and T. daenensis can be best identified by their TLC fingerprints obtained from dichloromethane extract. Conclusion: For best differentiation of various Thymus species, different extracts of the plants should be used.
Background: Thymus is a widely used medicinal plant in food and pharmaceutical industries. Among different species of Thymus, T. vulgaris is used more than other species in therapeutic dosage forms. Objective: This study was conducted to differentiate various Thymus species by TLC fingerprint. Methods: In order to identify and differentiate various species of Thymus, TLC fingerprints of essential oil, dichloromethane, ethylacetate and n-butanol extracts of four available species named T. vulgaris, T. pubescens, T. citriodorus and T. daenensis were obtained and compared with each other. Results: The results showed that the TLC chromatograms of essential oil and n-butanol extract can not be used as differential identification for the above-mentioned species while the ethylacetate and dichloromethane extracts are more reliable to be used for TLC fingerprints. TLC chromatogram of ethylacetate extract is specific for identification of T. pubescens and T. vulgaris while T. citriodorus and T. daenensis can be best identified by their TLC fingerprints obtained from dichloromethane extract. Conclusion: For best differentiation of various Thymus species, different extracts of the plants should be used.
;lt,i;gt,Thymus vulgaris;lt,/i;gt,, ;lt,i;gt,Thymus pubescens;lt,/i;gt,, ;lt,i;gt,Thymus citriodorus;lt,/i;gt,, ;lt,i;gt,Thymus daenensis;lt,/i;gt,, TLC fingerprint
;lt,i;gt,Thymus vulgaris;lt,/i;gt,, ;lt,i;gt,Thymus pubescens;lt,/i;gt,, ;lt,i;gt,Thymus citriodorus;lt,/i;gt,, ;lt,i;gt,Thymus daenensis;lt,/i;gt,, TLC fingerprint
19
24
http://jmp.ir/browse.php?a_code=A-10-241-1&slc_lang=en&sid=1
2009/05/52009/05/112009/04/21
1388/2/1
2009/07/42009/06/272009/05/27
1388/3/6
H
Hajimehdipoor
Food and Drug Control Laboratories and Food and Drug Laboratory Research Center, MOH & ME
H
Hajimehdipoor
00319475328460038250
00319475328460038250
No
Food and Drug Control Laboratories and Food and Drug Laboratory Research Center, MOH & ME
M
Khanavi
Department of Pharmacognosy, Tehran University of Medical Sciences
M
Khanavi
00319475328460038251
00319475328460038251
No
Department of Pharmacognosy, Tehran University of Medical Sciences
H
Zahedi
Food and Drug Control Laboratories and Food and Drug Laboratory Research Center, MOH & ME
H
Zahedi
00319475328460038252
00319475328460038252
No
Food and Drug Control Laboratories and Food and Drug Laboratory Research Center, MOH & ME
Z
Abedi
Food and Drug Control Laboratories and Food and Drug Laboratory Research Center, MOH & ME
Z
Abedi
00319475328460038253
00319475328460038253
No
Food and Drug Control Laboratories and Food and Drug Laboratory Research Center, MOH & ME
N
Kalantari Khandani
Food and Drug Control Laboratories and Food and Drug Laboratory Research Center, MOH & ME
N
Kalantari Khandani
00319475328460038254
00319475328460038254
No
Food and Drug Control Laboratories and Food and Drug Laboratory Research Center, MOH & ME
N
Adib
Food and Drug Control Laboratories and Food and Drug Laboratory Research Center, MOH & ME
N
Adib
00319475328460038255
00319475328460038255
No
Food and Drug Control Laboratories and Food and Drug Laboratory Research Center, MOH & ME
M
Pirali Hamedani
Department of Medicinal Chemistry and Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences
M
Pirali Hamedani
piraliha@sina.tums.ac.ir
00319475328460038256
00319475328460038256
Yes
Department of Medicinal Chemistry and Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences
en
Effect of Cumin Essential Oil on Postharvest Decay and Some Quality Factors of Strawberry
Effect of Cumin Essential Oil on Postharvest Decay and Some Quality Factors of Strawberry
Background: An essential oil is a liquid that is generally distilled from the leaves, stems, flowers or other elements of a plant. Objective: Cumin (Cuminum cyminum L.) Essential Oil (CEO) was analyzed to determine oil component. Antifungal effect of CEO was determined by in vitro technique. In second stage, effect of different concentrations of CEO by PDM on postharvest life of strawberry (Fragaria×ananassa Duch.) fruit, cultivar Selva, was studied. Methods: Antifungal effect of CEO was carried out with Paper Disk Method (PDM) and Solution Method (SM). In second stage Fruits were infected artificially by Botrytis cinerea spore, and then treated by different concentration of CEO. The rate of weight loss, fruit firmness, Total Soluble solids (TSS), titrable acidity, pH, ascorbic acid and color of fruits were determined at 0, 3, 6, 9, 12 and 15 days after the beginning of storage. The degree of infection on fruit was rated using a scale of 0 to 8, Fruit surface color was measured by Chromameter (CR 400, Minolta), TA by titration method, ascorbic acid content by iodometric method TSS content (Brix˚) by refractometer and pH by pH meter. Results: PDM was effective as antifungal. Storage life of the strawberry fruits was increased by the use of CEO significantly, by inhibition of fungal infection compared to controls. No significant fruit firmness, total soluble solids were observed in treated fruits compared to controls at all determination times. CEO treated fruit maintained higher L* at 3 and 6 day in compare with control. Titrable acidity, pH and ascorbic acid were significant in some stages. Conclusion: Results of present paper confirmed antifungal effect of CEO in both in vitro and on fruit postharvest. However, more studies are required to recommendation of CEO as a commercial and natural antifungal for increase postharvest on horticultural crops.
Background: An essential oil is a liquid that is generally distilled from the leaves, stems, flowers or other elements of a plant. Objective: Cumin (Cuminum cyminum L.) Essential Oil (CEO) was analyzed to determine oil component. Antifungal effect of CEO was determined by in vitro technique. In second stage, effect of different concentrations of CEO by PDM on postharvest life of strawberry (Fragaria×ananassa Duch.) fruit, cultivar Selva, was studied. Methods: Antifungal effect of CEO was carried out with Paper Disk Method (PDM) and Solution Method (SM). In second stage Fruits were infected artificially by Botrytis cinerea spore, and then treated by different concentration of CEO. The rate of weight loss, fruit firmness, Total Soluble solids (TSS), titrable acidity, pH, ascorbic acid and color of fruits were determined at 0, 3, 6, 9, 12 and 15 days after the beginning of storage. The degree of infection on fruit was rated using a scale of 0 to 8, Fruit surface color was measured by Chromameter (CR 400, Minolta), TA by titration method, ascorbic acid content by iodometric method TSS content (Brix˚) by refractometer and pH by pH meter. Results: PDM was effective as antifungal. Storage life of the strawberry fruits was increased by the use of CEO significantly, by inhibition of fungal infection compared to controls. No significant fruit firmness, total soluble solids were observed in treated fruits compared to controls at all determination times. CEO treated fruit maintained higher L* at 3 and 6 day in compare with control. Titrable acidity, pH and ascorbic acid were significant in some stages. Conclusion: Results of present paper confirmed antifungal effect of CEO in both in vitro and on fruit postharvest. However, more studies are required to recommendation of CEO as a commercial and natural antifungal for increase postharvest on horticultural crops.
Strawberry, Cumin, Antifungal, Postharvest, Essential oil
Strawberry, Cumin, Antifungal, Postharvest, Essential oil
25
43
http://jmp.ir/browse.php?a_code=A-10-235-1&slc_lang=en&sid=1
2009/05/52009/05/112009/04/212009/05/5
1388/2/15
2009/07/42009/06/272009/05/272009/08/10
1388/5/19
A
Asghari Marjanlo
Department of Horticultural Science, College of Agriculture and Natural Resources, University of Tehran
A
Asghari Marjanlo
00319475328460038257
00319475328460038257
No
Y
Mostofi
Department of Horticultural Science, College of Agriculture and Natural Resources, University of Tehran
Y
Mostofi
ymostofi@ut.ac.ir
00319475328460038258
00319475328460038258
Yes
Department of Horticultural Science, College of Agriculture and Natural Resources, University of Tehran
Sh
Shoeibi
Food and Drug Laboratory Research Center (FDLRC), Deputy for Food and Drug, MOH
Sh
Shoeibi
00319475328460038259
00319475328460038259
No
Food and Drug Laboratory Research Center (FDLRC), Deputy for Food and Drug, MOH
M
Fattahi
Department of Horticultural Science, College of Agriculture and Natural Resources, University of Tehran
M
Fattahi
00319475328460038260
00319475328460038260
No
Department of Horticultural Science, College of Agriculture and Natural Resources, University of Tehran
en
The Essential Oils of Tanacetum pinnatum Boiss. a Composite Herbs Growing Wild in Iran
The Essential Oils of Tanacetum pinnatum Boiss. a Composite Herbs Growing Wild in Iran
Background: The genus Tanacetum (Compositae) is represented by 26 species in the flora of Iran, 12 of them are endemic. One report on the analysis of essential oil of Tanacetum polycephalum Boiss. species has been published. Objective: Aim of this study is to determine the chemical composition of the hydrodistilled oil of Tanacetum pinnatum Boiss. of Iranian origin for the first time. Methods: The essential oil of T. pinnatum obtained by hydrodistillation and analyzed by GC and GC/MS. Results: The major constituents appeared to be camphor (23.2%), α-pinene (8.5%) and camphene (7.7%). Conclusion: In T. pinnatum we identified 25 components representing 98.7%. It was rich in regard to monoterpene hydrocarbons (78.9%). The sesquiterpene fraction was relatively small, representing 19.8%.
Background: The genus Tanacetum (Compositae) is represented by 26 species in the flora of Iran, 12 of them are endemic. One report on the analysis of essential oil of Tanacetum polycephalum Boiss. species has been published. Objective: Aim of this study is to determine the chemical composition of the hydrodistilled oil of Tanacetum pinnatum Boiss. of Iranian origin for the first time. Methods: The essential oil of T. pinnatum obtained by hydrodistillation and analyzed by GC and GC/MS. Results: The major constituents appeared to be camphor (23.2%), α-pinene (8.5%) and camphene (7.7%). Conclusion: In T. pinnatum we identified 25 components representing 98.7%. It was rich in regard to monoterpene hydrocarbons (78.9%). The sesquiterpene fraction was relatively small, representing 19.8%.
;lt,i;gt,Tanacetum pinnatum;lt,/i;gt,, Compositae, Essential oil, Camphor, α-pinene
;lt,i;gt,Tanacetum pinnatum;lt,/i;gt,, Compositae, Essential oil, Camphor, α-pinene
44
49
http://jmp.ir/browse.php?a_code=A-10-236-1&slc_lang=en&sid=1
2009/05/52009/05/112009/04/212009/05/52009/04/11
1388/1/22
2009/07/42009/06/272009/05/272009/08/102009/06/13
1388/3/23
A
Esmaeili
Department of Chemical Engineering, North Tehran Branch, Islamic Azad University
A
Esmaeili
akbaresmaeili@yahoo.com
00319475328460038261
00319475328460038261
Yes
Department of Chemical Engineering, North Tehran Branch, Islamic Azad University
H
Amiri
Department of Biology, Lorestan University, Khoramabad
H
Amiri
00319475328460038262
00319475328460038262
No
Department of Biology, Lorestan University, Khoramabad
Sh
Rezazadeh
Department of Pharmacognosy and Pharmaceutics, Institute of Medicinal Plants, ACECR
Sh
Rezazadeh
00319475328460038263
00319475328460038263
No
Department of Pharmacognosy and Pharmaceutics, Institute of Medicinal Plants, ACECR
en
The Ethnopharmacological Study on Antibacterial Activity of some Selected Plants Used in Iranian Traditional Medicine
The Ethnopharmacological Study on Antibacterial Activity of some Selected Plants Used in Iranian Traditional Medicine
Background: Iran is a land of great heritage of ancient medical scholars. Herbal medicines, as a basement of treatment of diseases have been clearly described in the medical texts of these scholars including Rhazes, Avicenna, and others. Numerous plants are introduced in these texts to treat those diseases likely to be infective ones. Few attempts have been made to evaluate ethnopharmacological aspects of these plants. Objective: In the present study selected specimens of plants described in ancient Iranian medical texts to treat infective conditions were evaluated for antibacterial activity. The hypothesis of this study was that the plants described in the ancient medical texts possess antibacterial properties. Methods: In this study, ten specimens of these plants were selected from various texts. Their scientific terminologies were prepared based on various respected sources. The antibacterial activity of hydroalcoholic extracts of these herbs, as well as their MICs and MBCs were evaluated according to standard techniques. Results: Results of this study showed that almost all of 10 specimens showed considerable antibacterial activity. The MIC and MBC of some herbs showed strong activity against gram positive and gram negative microorganisms. MICs and MBCs of Heracleum persicum and antibacterial activity of Zea mays are reported for the first time in this study. Conclusion: The antibacterial activity of the selected plants supports their old uses as anti-infective agents. The results of this survey also showed antibacterial activity of Arnebia euchroma (Royle) Johst. and Teucrium polium L. traditionally used as poultice for infective wounds. H. persicum traditionally used in Iran as spice can play a valuable role in preventing food poisoning. The data of this study supported the importance of ethnopharmacological approach and opened also the new doors to future researches in this field.
Background: Iran is a land of great heritage of ancient medical scholars. Herbal medicines, as a basement of treatment of diseases have been clearly described in the medical texts of these scholars including Rhazes, Avicenna, and others. Numerous plants are introduced in these texts to treat those diseases likely to be infective ones. Few attempts have been made to evaluate ethnopharmacological aspects of these plants. Objective: In the present study selected specimens of plants described in ancient Iranian medical texts to treat infective conditions were evaluated for antibacterial activity. The hypothesis of this study was that the plants described in the ancient medical texts possess antibacterial properties. Methods: In this study, ten specimens of these plants were selected from various texts. Their scientific terminologies were prepared based on various respected sources. The antibacterial activity of hydroalcoholic extracts of these herbs, as well as their MICs and MBCs were evaluated according to standard techniques. Results: Results of this study showed that almost all of 10 specimens showed considerable antibacterial activity. The MIC and MBC of some herbs showed strong activity against gram positive and gram negative microorganisms. MICs and MBCs of Heracleum persicum and antibacterial activity of Zea mays are reported for the first time in this study. Conclusion: The antibacterial activity of the selected plants supports their old uses as anti-infective agents. The results of this survey also showed antibacterial activity of Arnebia euchroma (Royle) Johst. and Teucrium polium L. traditionally used as poultice for infective wounds. H. persicum traditionally used in Iran as spice can play a valuable role in preventing food poisoning. The data of this study supported the importance of ethnopharmacological approach and opened also the new doors to future researches in this field.
Herbal Medicine, Ethnopharmacology, Anti- Infective Agents
Herbal Medicine, Ethnopharmacology, Anti- Infective Agents
50
57
http://jmp.ir/browse.php?a_code=A-10-205-2&slc_lang=en&sid=1
2009/05/52009/05/112009/04/212009/05/52009/04/112009/04/11
1388/1/22
2009/07/42009/06/272009/05/272009/08/102009/06/132009/05/24
1388/3/3
MM
Ahmadian-Attari
Department of Traditional Pharmacy, Faculty of Traditional Medicine and Islamic Era, Shahid Beheshti University of Medical Sciences
MM
Ahmadian-Attari
00319475328460038264
00319475328460038264
No
Department of Traditional Pharmacy, Faculty of Traditional Medicine and Islamic Era, Shahid Beheshti University of Medical Sciences
HR
Monsef Esfahani
Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences
HR
Monsef Esfahani
00319475328460038265
00319475328460038265
No
Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences
GR
Amin
Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences
GR
Amin
00319475328460038266
00319475328460038266
No
Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences
MR
Fazeli
Department of Pharmaceutical and Food Control, Faculty of Pharmacy, Tehran University of Medical Sciences
MR
Fazeli
00319475328460038267
00319475328460038267
No
Department of Pharmaceutical and Food Control, Faculty of Pharmacy, Tehran University of Medical Sciences
H
Jamalifar
Department of Pharmaceutical and Food Control, Faculty of Pharmacy, Tehran University of Medical Sciences
H
Jamalifar
00319475328460038268
00319475328460038268
No
Department of Pharmaceutical and Food Control, Faculty of Pharmacy, Tehran University of Medical Sciences
G
Kamalinia
Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences
G
Kamalinia
00319475328460038269
00319475328460038269
No
Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences
M
Khanlarbeik
Department of Pharmaceutical and Food Control, Faculty of Pharmacy, Tehran University of Medical Sciences
M
Khanlarbeik
00319475328460038270
00319475328460038270
No
Department of Pharmaceutical and Food Control, Faculty of Pharmacy, Tehran University of Medical Sciences
H
Ashtiani
Department of Pharmaceutical and Food Control, Faculty of Pharmacy, Tehran University of Medical Sciences
H
Ashtiani
00319475328460038271
00319475328460038271
No
Department of Pharmaceutical and Food Control, Faculty of Pharmacy, Tehran University of Medical Sciences
H
Farsam
Department of medicinal chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences
H
Farsam
Farsam@sina.tums.ac.ir
00319475328460038272
00319475328460038272
Yes
Department of medicinal chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences
en
Chemical Composition and Antimicrobial Activities of the Essential Oils from Flower and Leaves of Lagochilus kotschyanus Boiss. A New Species from Iran
Chemical Composition and Antimicrobial Activities of the Essential Oils from Flower and Leaves of Lagochilus kotschyanus Boiss. A New Species from Iran
Background: The genus lagochilus, family Lamiaceae consists of 44 species, 33 of which grow in central Asia. Only one report on the analysis of essential oil of Lagochilus species has been published. Objective: Aim of this study is to determine the chemical composition and antimicrobial activities of the hydrodistilled oil of flower and leaves of Lagochilus kotschyanus Boiss. of Iranian origin for the first time. Methods: The essential oils obtained by hydrodistillation from the flower and leaves of L. kotschyanus were analyzed by GC and GC/MS. The antimicrobial activities were determined by measuring the growth inhibitory zones (well diffusion assay). Results: The major constituents of the flower and leaf oils appeared to be myrcene (28.2% and 36.6%), α-pinene (25.9% and 29.8%) and β-caryophyllene (10.3% and 9.4%), respectively. Conclusion: In L. kotschyanus we identified 34 components representing 95.2% and 18 constituents representing 96.3% of the flower and leaf oils, respectively. Both oils were rich in regard to monoterpene hydrocarbons (72.7% and 79.7%) respectively. The sesquiterpene fraction was relatively small, representing 19.4% and 14.1%, respectively. Antibacterial activity was measured using the growth inhibitory zones. It was found that oil from leaves and flowers of L. kotschyanus, and especially that of flowers, exhibited interesting antibacterial activity.
Background: The genus lagochilus, family Lamiaceae consists of 44 species, 33 of which grow in central Asia. Only one report on the analysis of essential oil of Lagochilus species has been published. Objective: Aim of this study is to determine the chemical composition and antimicrobial activities of the hydrodistilled oil of flower and leaves of Lagochilus kotschyanus Boiss. of Iranian origin for the first time. Methods: The essential oils obtained by hydrodistillation from the flower and leaves of L. kotschyanus were analyzed by GC and GC/MS. The antimicrobial activities were determined by measuring the growth inhibitory zones (well diffusion assay). Results: The major constituents of the flower and leaf oils appeared to be myrcene (28.2% and 36.6%), α-pinene (25.9% and 29.8%) and β-caryophyllene (10.3% and 9.4%), respectively. Conclusion: In L. kotschyanus we identified 34 components representing 95.2% and 18 constituents representing 96.3% of the flower and leaf oils, respectively. Both oils were rich in regard to monoterpene hydrocarbons (72.7% and 79.7%) respectively. The sesquiterpene fraction was relatively small, representing 19.4% and 14.1%, respectively. Antibacterial activity was measured using the growth inhibitory zones. It was found that oil from leaves and flowers of L. kotschyanus, and especially that of flowers, exhibited interesting antibacterial activity.
;lt,i;gt,Lagochilus kotschyanus;lt,/i;gt,, Lamiaceae, Essential oil composition, Myrcene, α-pinene, β-caryophyllene, Antimicrobial activity
;lt,i;gt,Lagochilus kotschyanus;lt,/i;gt,, Lamiaceae, Essential oil composition, Myrcene, α-pinene, β-caryophyllene, Antimicrobial activity
58
63
http://jmp.ir/browse.php?a_code=A-10-194-2&slc_lang=en&sid=1
2009/05/52009/05/112009/04/212009/05/52009/04/112009/04/112009/05/25
1388/3/4
2009/07/42009/06/272009/05/272009/08/102009/06/132009/05/242009/08/24
1388/6/2
S
Taban
Department of Chemistry, Saveh Branch, Islamic Azad University Saveh
S
Taban
00319475328460038273
00319475328460038273
No
Department of Chemistry, Saveh Branch, Islamic Azad University Saveh
Sh
Masoudi
Department of Chemistry, Central Tehran Branch, Islamic Azad University
Sh
Masoudi
00319475328460038274
00319475328460038274
No
Department of Chemistry, Central Tehran Branch, Islamic Azad University
F
Chalabian
Department of Biology, Tehran North Campus, Islamic Azad University
F
Chalabian
00319475328460038275
00319475328460038275
No
Department of Biology, Tehran North Campus, Islamic Azad University
B
Delnavaz
Department of Chemistry, Saveh Branch, Islamic Azad University Saveh
B
Delnavaz
00319475328460038276
00319475328460038276
No
Department of Chemistry, Saveh Branch, Islamic Azad University Saveh
A
Rustaiyan
Department of Chemistry, Science and Research Campus, Islamic Azad University
A
Rustaiyan
arustaiyan@yahoo.it
00319475328460038277
00319475328460038277
Yes
Department of Chemistry, Science and Research Campus, Islamic Azad University
en
The Fruit Essential oil of Cuminum cyminum L. Reduced the Acquisition but not Expression of Ineffective dose of Morphine-Induced Conditioned Place Preference in Morphine- Sensitized Mice
The Fruit Essential oil of Cuminum cyminum L. Reduced the Acquisition but not Expression of Ineffective dose of Morphine-Induced Conditioned Place Preference in Morphine- Sensitized Mice
Background: Cuminum cyminum fruit essential oil (FEO) dose-dependently can attenuate the expression of morphine tolerance and dependence in morphine-dependent mice. Objective: In this study, the effects of Cuminum cyminum FEO on acquisition and expression of morphine-induced conditioned place preference (CPP) in morphine-sensitized mice were studied. Methods: Repeated subcutaneous (s.c.) administration of morphine (5 mg/kg), once daily for three and 5 days free of the opioid (sensitization period), increased conditioning response induced by ineffective doses of morphine (0.25, 0.5 and 0.75 mg/kg). Results: The results showed that intra-peritoneal (i.p.) injection of Cumin FEO (0.001, 0.01, 0.1, 0.5, 1 and 2% 5 ml/kg) or Tween-80 (0.5% 5 ml/kg), 60 min before administration of morphine or saline during sensitization period (acquisition), decreased the conditioning response induced by ineffective dose of morphine (0.5 mg/kg s.c.) at the doses of 1% (P<0.05) and 2% (P<0.001) while Cumin FEO (0.001-2% i.p.), just 60 min before the test on post-conditioning phase (expression experiments), did not alter the conditioning scores in morphine- and non-sensitized mice. Conclusion: Our findings showed that the Cuminum cyminum fruit essential oil reduces the acquisition but not expression of morphine-induced conditioned place preference in morphine-sensitized mice.
Background: Cuminum cyminum fruit essential oil (FEO) dose-dependently can attenuate the expression of morphine tolerance and dependence in morphine-dependent mice. Objective: In this study, the effects of Cuminum cyminum FEO on acquisition and expression of morphine-induced conditioned place preference (CPP) in morphine-sensitized mice were studied. Methods: Repeated subcutaneous (s.c.) administration of morphine (5 mg/kg), once daily for three and 5 days free of the opioid (sensitization period), increased conditioning response induced by ineffective doses of morphine (0.25, 0.5 and 0.75 mg/kg). Results: The results showed that intra-peritoneal (i.p.) injection of Cumin FEO (0.001, 0.01, 0.1, 0.5, 1 and 2% 5 ml/kg) or Tween-80 (0.5% 5 ml/kg), 60 min before administration of morphine or saline during sensitization period (acquisition), decreased the conditioning response induced by ineffective dose of morphine (0.5 mg/kg s.c.) at the doses of 1% (P<0.05) and 2% (P<0.001) while Cumin FEO (0.001-2% i.p.), just 60 min before the test on post-conditioning phase (expression experiments), did not alter the conditioning scores in morphine- and non-sensitized mice. Conclusion: Our findings showed that the Cuminum cyminum fruit essential oil reduces the acquisition but not expression of morphine-induced conditioned place preference in morphine-sensitized mice.
;lt,i;gt,Cuminum cyminum;lt,/i;gt,, Morphine, Conditioned place preference, Sensitization, Mice
;lt,i;gt,Cuminum cyminum;lt,/i;gt,, Morphine, Conditioned place preference, Sensitization, Mice
64
74
http://jmp.ir/browse.php?a_code=A-10-237-1&slc_lang=en&sid=1
2009/05/52009/05/112009/04/212009/05/52009/04/112009/04/112009/05/252009/05/24
1388/3/3
2009/07/42009/06/272009/05/272009/08/102009/06/132009/05/242009/08/242009/07/13
1388/4/22
A
Haghparast
Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran
A
Haghparast
Haghparast@yahoo.com
00319475328460038278
00319475328460038278
Yes
Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran
J
Zarringhalam
Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran
J
Zarringhalam
00319475328460038279
00319475328460038279
No
Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran
A
Khatibi
Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran
A
Khatibi
00319475328460038280
00319475328460038280
No
Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran
E
Dianati
Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran
E
Dianati
00319475328460038281
00319475328460038281
No
Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran
J
Shams
Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran
J
Shams
00319475328460038282
00319475328460038282
No
Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran
en
Antibacterial Activity Directed Fractionation of Woodfordia fruticosa Kurz. Leaves
Antibacterial Activity Directed Fractionation of Woodfordia fruticosa Kurz. Leaves
Background: Woodfordia fruticosa is used traditionally as antidysenteric compound for fodder animals. Stem and flower extracts are previously flourished for their antibacterial activity. Leaves are also equally important, which are preliminary screened for their bioactive components in present study. Objective: Evaluation of antibacterial activity of leaves of W. fruticosa and detection of their active compound. Methods: Different solvent i.e. petroleum ether, chloroform, diethyl ether and acetone extracts were studied against four bacterial strains using disc diffusion assay. Most potenz extract was chromatogram on preparative TLC. Further individual separated spots were back checked for their activity. Probable constituents of most active fraction were detected on GC-MS. Results: All four extracts exhibited antibacterial activity. The acetone extract showed highest inhibition against Bacillus subtilis NCIM 2921. The 80 μg and 120 μg of acetone extract exhibit comparable antimicrobial activity against the four different bacteria studied. Amongst the four different spots on TLC chromatogram three of them had activity against B. subtilis NCIM 2921. The most active fraction was collected by preparative TLC and used for GC-MS, which exhibited two peaks. Conclusion: Extracts of petroleum ether, chloroform, diethyl ether and acetone were found to be effective against all the srains studied. The fraction of acetone extract, which is more active, constitutes two different compounds, in which both or one of them is responsible for antibacterial activity.
Background: Woodfordia fruticosa is used traditionally as antidysenteric compound for fodder animals. Stem and flower extracts are previously flourished for their antibacterial activity. Leaves are also equally important, which are preliminary screened for their bioactive components in present study. Objective: Evaluation of antibacterial activity of leaves of W. fruticosa and detection of their active compound. Methods: Different solvent i.e. petroleum ether, chloroform, diethyl ether and acetone extracts were studied against four bacterial strains using disc diffusion assay. Most potenz extract was chromatogram on preparative TLC. Further individual separated spots were back checked for their activity. Probable constituents of most active fraction were detected on GC-MS. Results: All four extracts exhibited antibacterial activity. The acetone extract showed highest inhibition against Bacillus subtilis NCIM 2921. The 80 μg and 120 μg of acetone extract exhibit comparable antimicrobial activity against the four different bacteria studied. Amongst the four different spots on TLC chromatogram three of them had activity against B. subtilis NCIM 2921. The most active fraction was collected by preparative TLC and used for GC-MS, which exhibited two peaks. Conclusion: Extracts of petroleum ether, chloroform, diethyl ether and acetone were found to be effective against all the srains studied. The fraction of acetone extract, which is more active, constitutes two different compounds, in which both or one of them is responsible for antibacterial activity.
;lt,i;gt,Woodfordia fruticosa;lt,/i;gt,, Antibacterial activity, Solvent validation, Bioactive components
;lt,i;gt,Woodfordia fruticosa;lt,/i;gt,, Antibacterial activity, Solvent validation, Bioactive components
75
81
http://jmp.ir/browse.php?a_code=A-10-238-1&slc_lang=en&sid=1
2009/05/52009/05/112009/04/212009/05/52009/04/112009/04/112009/05/252009/05/242009/04/5
1388/1/16
2009/07/42009/06/272009/05/272009/08/102009/06/132009/05/242009/08/242009/07/132009/06/15
1388/3/25
AD
Chougale
Biochemistry Department, NACAS College, Pune University, Maharashtra-414001
AD
Chougale
00319475328460038283
00319475328460038283
No
Biochemistry Department, NACAS College, Pune University, Maharashtra-414001
MV
Padul
Biochemistry Department, NACAS College, Pune University, Maharashtra-414001
MV
Padul
manoharpadul@yahoo.co.in
00319475328460038284
00319475328460038284
Yes
Biochemistry Department, NACAS College, Pune University, Maharashtra-414001
Md
Saiful Arfeen
Biotechnology Department, NACAS College, Pune University, Maharashtra-414001
Md
Saiful Arfeen
00319475328460038285
00319475328460038285
No
Biotechnology Department, NACAS College, Pune University, Maharashtra-414001
SL
Kakad
Biochemistry Department, NACAS College, Pune University, Maharashtra-414001
SL
Kakad
00319475328460038286
00319475328460038286
No
Biochemistry Department, NACAS College, Pune University, Maharashtra-414001
en
Chemical Composition of the Essential Oil from Leaves and Flowering Aerial Parts of Psammogeton canescens (DC.) Vake from Iran
Chemical Composition of the Essential Oil from Leaves and Flowering Aerial Parts of Psammogeton canescens (DC.) Vake from Iran
Background: The genus Psammogeton Edyew. which belong to the umbelliferae family, is found in central areas of Asia. This genus consists of six species widespread in the sandy dunes of deserts. Among the four species present in Iran, Pssamogeton canescens (DC.) vatke is distributed in regions of Iran central. Objective: The aim of this study is to determine the chemical composition of essential oil of Psammogeton canescens. Methods: The essential oil was extracted by hydrodistillation of dried aerial part of plant and analysed by GC and GC/MS. Results: Thirty constituents representing 99.7% of total oil have been identified. The main constituents of the oil were found to be β-bisabolene (33.35%), Apiole (28.34 %), α-Pinene (11.86%) and Dill apiole (8.17%). Other representative compounds were identified as β-Pinene (2.68%), Myrcene (2.62%) and sylvestrene (2.42%). Conclusion: Amounting to 99.7% of the total oil, the sesquiterpene hydrocarbons and oxygenated sesquiterpene had the highest contribution (78.16%), these fractions dominated by β-bisabolene (33.35%), followed by Apiole (28.34%) and Dill apiole (8.17%). The diterpene was very poor it represented (0.49%), it is found to contain only a few percent of cembrene (0.49).
Background: The genus Psammogeton Edyew. which belong to the umbelliferae family, is found in central areas of Asia. This genus consists of six species widespread in the sandy dunes of deserts. Among the four species present in Iran, Pssamogeton canescens (DC.) vatke is distributed in regions of Iran central. Objective: The aim of this study is to determine the chemical composition of essential oil of Psammogeton canescens. Methods: The essential oil was extracted by hydrodistillation of dried aerial part of plant and analysed by GC and GC/MS. Results: Thirty constituents representing 99.7% of total oil have been identified. The main constituents of the oil were found to be β-bisabolene (33.35%), Apiole (28.34 %), α-Pinene (11.86%) and Dill apiole (8.17%). Other representative compounds were identified as β-Pinene (2.68%), Myrcene (2.62%) and sylvestrene (2.42%). Conclusion: Amounting to 99.7% of the total oil, the sesquiterpene hydrocarbons and oxygenated sesquiterpene had the highest contribution (78.16%), these fractions dominated by β-bisabolene (33.35%), followed by Apiole (28.34%) and Dill apiole (8.17%). The diterpene was very poor it represented (0.49%), it is found to contain only a few percent of cembrene (0.49).
;lt,i;gt,Psammogeton canescens;lt,/i;gt,, ;lt,i;gt,Umbelliferae;lt,/i;gt,, Essential oil, β-bisabolene, Apiole
;lt,i;gt,Psammogeton canescens;lt,/i;gt,, ;lt,i;gt,Umbelliferae;lt,/i;gt,, Essential oil, β-bisabolene, Apiole
82
86
http://jmp.ir/browse.php?a_code=A-10-239-1&slc_lang=en&sid=1
2009/05/52009/05/112009/04/212009/05/52009/04/112009/04/112009/05/252009/05/242009/04/52009/06/13
1388/3/23
2009/07/42009/06/272009/05/272009/08/102009/06/132009/05/242009/08/242009/07/132009/06/152009/08/26
1388/6/4
M
Rahimi-Nasrabadi
Department of Chemistry, Razi University, Kermanshah
M
Rahimi-Nasrabadi
rahiminasrabadi@gmail.com
00319475328460038287
00319475328460038287
Yes
Department of Chemistry, Razi University, Kermanshah
MB
Gholivand
Department of Chemistry, Razi University, Kermanshah
MB
Gholivand
00319475328460038288
00319475328460038288
No
Department of Chemistry, Razi University, Kermanshah
H
Batooli
Isfahan Research Center of Natural Sources and Agriculture, Kashan Station
H
Batooli
00319475328460038289
00319475328460038289
No
Isfahan Research Center of Natural Sources and Agriculture, Kashan Station
A
Vatanara
Department of Pharmaceutics, School of Pharmacy, Tehran University of Medical Sciences
A
Vatanara
00319475328460038290
00319475328460038290
No
Department of Pharmaceutics, School of Pharmacy, Tehran University of Medical Sciences
en
Effects of Danae racemosa on Spermatogenesis in Rat
Effects of Danae racemosa on Spermatogenesis in Rat
Background: Danae racemosa is used medicinally and as a culinary spice. Its constituents are stated to have antithrombotic, antihepatotoxic, antinociceptive and antioxidant. Objective: Enhanced oxidative stress and changes in antioxidant capacity are considered to play an important role in the pathogenesis of chronic diabetes mellitus. Methods: Wistar male rat (n=30) were allocated into three groups, control (n=10) and two test groups (each of ten). Animals in test groups were subdivided into groups of 2 that received fresh extract equivalent to 200 & 400 mg/Kg/Rat/day Danae racemosa extract. Fresh Danae racemosa extract was administered with gavages for 28 consecutive days. Animals were kept in standard condition. On twenty eighth day, the testes of rats in the all groups were removed and sperm was collected from epididymis and was prepared for analysis. Results: The percentage of sperm viability and motility in both test groups significantly increased (p<0.05), but the sperm concentration significantly increased only in the group that received the high dose of Danae racemosa extracted, (p<0.05). It was evident that there was no difference on sperm morphology and testis weight in test groups comparing to control group. Conclusion: In our study Danae racemosa extract has significantly affected the sperm number and percentage of viability and motility it seems that using 400 mg/Kg/Rat/day of Danae racemosa extract is effective in sperm health parameters.
Background: Danae racemosa is used medicinally and as a culinary spice. Its constituents are stated to have antithrombotic, antihepatotoxic, antinociceptive and antioxidant. Objective: Enhanced oxidative stress and changes in antioxidant capacity are considered to play an important role in the pathogenesis of chronic diabetes mellitus. Methods: Wistar male rat (n=30) were allocated into three groups, control (n=10) and two test groups (each of ten). Animals in test groups were subdivided into groups of 2 that received fresh extract equivalent to 200 & 400 mg/Kg/Rat/day Danae racemosa extract. Fresh Danae racemosa extract was administered with gavages for 28 consecutive days. Animals were kept in standard condition. On twenty eighth day, the testes of rats in the all groups were removed and sperm was collected from epididymis and was prepared for analysis. Results: The percentage of sperm viability and motility in both test groups significantly increased (p<0.05), but the sperm concentration significantly increased only in the group that received the high dose of Danae racemosa extracted, (p<0.05). It was evident that there was no difference on sperm morphology and testis weight in test groups comparing to control group. Conclusion: In our study Danae racemosa extract has significantly affected the sperm number and percentage of viability and motility it seems that using 400 mg/Kg/Rat/day of Danae racemosa extract is effective in sperm health parameters.
;lt,i;gt,Danae racemosa;lt,/i;gt,, Extract, Sperm, Rat
;lt,i;gt,Danae racemosa;lt,/i;gt,, Extract, Sperm, Rat
87
92
http://jmp.ir/browse.php?a_code=A-10-176-7&slc_lang=en&sid=1
2009/05/52009/05/112009/04/212009/05/52009/04/112009/04/112009/05/252009/05/242009/04/52009/06/132009/06/16
1388/3/26
2009/07/42009/06/272009/05/272009/08/102009/06/132009/05/242009/08/242009/07/132009/06/152009/08/262009/08/24
1388/6/2
A
Khaki
Department of Veterinary Pathology (YRC), Islamic Azad University Tabriz Branch
A
Khaki
arashkhaki@yahoo.com
00319475328460038291
00319475328460038291
Yes
Department of Veterinary Pathology (YRC), Islamic Azad University Tabriz Branch
F
Fathiazad
Department of Pharmacognosy Tabriz University of Medical Sciences
F
Fathiazad
00319475328460038292
00319475328460038292
No
Department of Pharmacognosy Tabriz University of Medical Sciences
HR
Ahmadi - Ashtiani
Department of Clinical Biochemistry, School of Medical Science, Tarbiat Modarres University, Tehran, Iran; Biochemistry & Nutrition Department of Zanjan Medical University
HR
Ahmadi - Ashtiani
00319475328460038293
00319475328460038293
No
Department of Clinical Biochemistry, School of Medical Science, Tarbiat Modarres University, Tehran, Iran; Biochemistry & Nutrition Department of Zanjan Medical University
H
Rastgar
Ministry of Health and Medical Education, Food & Drug Laboratory Research center
H
Rastgar
00319475328460038294
00319475328460038294
No
Ministry of Health and Medical Education, Food & Drug Laboratory Research center
Sh
Rezazadeh
Institute of Medicinal Plants, ACECR
Sh
Rezazadeh
00319475328460038295
00319475328460038295
No
Institute of Medicinal Plants, ACECR
en
Composition and Antibacterial Activity of the Volatile Oils from Different Parts of Achillea tenuifolia Lam. from Iran
Composition and Antibacterial Activity of the Volatile Oils from Different Parts of Achillea tenuifolia Lam. from Iran
Background: Achillea tenuifolia Lam. (Compositae) with small yellow flowers and several times pinnately divided leaves in worm shape is known for many years in the folk medicine. It has been used to reduce sweating and to stop bleeding. It helps regulation of the menstrual cycle and reduces heavy bleeding and pain. Materials and Methods: Plant material (flower, leaf and stem) was collected in Khalkhal – Ardabil road area, at an altitude of 1650 m in Northwest of Iran. Plant materials were air dried 150g of flower 150g of leaf and 200g of stem were subjected to 3h of hydrodistillation in a Clevenger-type apparatus, separately. The hydrodistilled essential oils were analyzed by GC and GC/MS methods. Antibacterial activities of the oils were evaluated by the disc diffusion method using Mueller-Hinton agar for bacteria. Results: The oil of flower was characterized by higher amount of limonene (23.2%) and α-cadinol (18.2%). Twenty one constituents representing (92.2%) of the leaf oil were identified of which limonene (25.2%), α- pinene (14.4%), caryophyllene oxide (6.5%), α- gurjunene (6.3%), bornyl acetate (5.5%) and δ-cadinene (4.4%) were major components. The main components of the stem oil were limonene (23.6%), α- pinene (13.4%) and spathulenol (6.4%). The oils showed inhibitory effects on Escherichia coli and Salmonella typhi. Conclusions: The main components of the oil of flower, leaf and stem were limonene, α-cadinol, α- pinene and spathulenol, but Borneol, bornyl acetate, camphor, α- and β-thujone, and 1, 8-cineol were found as the main components of essential oils of many other Achillea species. These variations may be attributed mainly to variation in their agroclimatic and geographical conditions. The results indicated that three oils were found to be active against bacteria, the oil from the flower was found to be more active than the oil from the leaf and stem.
Background: Achillea tenuifolia Lam. (Compositae) with small yellow flowers and several times pinnately divided leaves in worm shape is known for many years in the folk medicine. It has been used to reduce sweating and to stop bleeding. It helps regulation of the menstrual cycle and reduces heavy bleeding and pain. Materials and Methods: Plant material (flower, leaf and stem) was collected in Khalkhal – Ardabil road area, at an altitude of 1650 m in Northwest of Iran. Plant materials were air dried 150g of flower 150g of leaf and 200g of stem were subjected to 3h of hydrodistillation in a Clevenger-type apparatus, separately. The hydrodistilled essential oils were analyzed by GC and GC/MS methods. Antibacterial activities of the oils were evaluated by the disc diffusion method using Mueller-Hinton agar for bacteria. Results: The oil of flower was characterized by higher amount of limonene (23.2%) and α-cadinol (18.2%). Twenty one constituents representing (92.2%) of the leaf oil were identified of which limonene (25.2%), α- pinene (14.4%), caryophyllene oxide (6.5%), α- gurjunene (6.3%), bornyl acetate (5.5%) and δ-cadinene (4.4%) were major components. The main components of the stem oil were limonene (23.6%), α- pinene (13.4%) and spathulenol (6.4%). The oils showed inhibitory effects on Escherichia coli and Salmonella typhi. Conclusions: The main components of the oil of flower, leaf and stem were limonene, α-cadinol, α- pinene and spathulenol, but Borneol, bornyl acetate, camphor, α- and β-thujone, and 1, 8-cineol were found as the main components of essential oils of many other Achillea species. These variations may be attributed mainly to variation in their agroclimatic and geographical conditions. The results indicated that three oils were found to be active against bacteria, the oil from the flower was found to be more active than the oil from the leaf and stem.
;lt,i;gt,Achillea tenuifolia;lt,/i;gt,, Compositae, Essential oil composition, Limonene, α-cadinol
;lt,i;gt,Achillea tenuifolia;lt,/i;gt,, Compositae, Essential oil composition, Limonene, α-cadinol
93
98
http://jmp.ir/browse.php?a_code=A-10-193-2&slc_lang=en&sid=1
2009/05/52009/05/112009/04/212009/05/52009/04/112009/04/112009/05/252009/05/242009/04/52009/06/132009/06/162009/04/20
1388/1/31
2009/07/42009/06/272009/05/272009/08/102009/06/132009/05/242009/08/242009/07/132009/06/152009/08/262009/08/242009/06/15
1388/3/25
A
Shafaghat
Department of Chemistry, Islamic Azad University, Khalkhal Branch, Khalkhal
A
Shafaghat
shafaghata@yahoo.com
00319475328460038296
00319475328460038296
Yes
Department of Chemistry, Islamic Azad University, Khalkhal Branch, Khalkhal
en
The Effects of Fruit Maturity and 1-Methylcyclopropene (1-MCP) Treatment on α-farnesene Metabolism in Scald Resistant and Susceptible Cultivars of Apple Fruit
The Effects of Fruit Maturity and 1-Methylcyclopropene (1-MCP) Treatment on α-farnesene Metabolism in Scald Resistant and Susceptible Cultivars of Apple Fruit
Background: It was found that, climatic conditions and fruit ripeness are important factor for the occurrence and intensity of superficial scald. 1-MCP is an inhibitor of ethylene action in plants and inhibits many ripening related processes along with the production of ethylene and volatiles. Objective: Apples are often held for several months at low temperature either in air (RA) or in controlled atmosphere (CA) storage, therefore they are prone to the occurrence of a large number of physiological disorders. In this work an investigation was made in order to determine the effect of 1-methylcyclopropene (1.0 µl l-1) treatment on superficial scald development and α-farnesene metabolism on scald-resistant ‘Golden Delicious’ and scald-susceptible ‘Imperial Delicious ' apples. Methods: Fruits harvested on two dates and stored 24 weeks in refrigerated air storage (RA) at 0.5-1 °C. Peel tissue samples were taken at harvest after 6, 12 and 24 weeks. A reversed-phase high-performance liquid chromatographic procedure with UV detection at 232 nm and 269 nm has been used for the determination of α-farnesene and Ctols contents. Results: Scald symptoms were restricted to untreated control fruit of both harvests of Imperial as during storage period increased to 65 and 45%, respectively for the first and second harvest compared with no scald symptoms in those in Golden Delicious. At 1.0 µl l-1, 1-MCP completely eliminated superficial scald during storage period in Imperial apples. Large increases in peel tissue content of α-farnesene observed in untreated fruit of both harvest dates in Golden Delicious and Imperial cultivars. 1-MCP strongly decreased α-farnesene and conjugated trienols accumulation in treated fruit peel tissues at both maturity stages of two cultivars during storage. The results confirm the proposed role of Ctols in scald induction and indicate that α-farnesene production is strongly regulated by ethylene. Conclusion: In general, we conclude that only α-farnesene synthesis and its oxidation products (Ctols) levels in peel tissue could not be involved to the inherent nature of scald susceptibility or resistance in two cultivars tested.
Background: It was found that, climatic conditions and fruit ripeness are important factor for the occurrence and intensity of superficial scald. 1-MCP is an inhibitor of ethylene action in plants and inhibits many ripening related processes along with the production of ethylene and volatiles. Objective: Apples are often held for several months at low temperature either in air (RA) or in controlled atmosphere (CA) storage, therefore they are prone to the occurrence of a large number of physiological disorders. In this work an investigation was made in order to determine the effect of 1-methylcyclopropene (1.0 µl l-1) treatment on superficial scald development and α-farnesene metabolism on scald-resistant ‘Golden Delicious’ and scald-susceptible ‘Imperial Delicious ' apples. Methods: Fruits harvested on two dates and stored 24 weeks in refrigerated air storage (RA) at 0.5-1 °C. Peel tissue samples were taken at harvest after 6, 12 and 24 weeks. A reversed-phase high-performance liquid chromatographic procedure with UV detection at 232 nm and 269 nm has been used for the determination of α-farnesene and Ctols contents. Results: Scald symptoms were restricted to untreated control fruit of both harvests of Imperial as during storage period increased to 65 and 45%, respectively for the first and second harvest compared with no scald symptoms in those in Golden Delicious. At 1.0 µl l-1, 1-MCP completely eliminated superficial scald during storage period in Imperial apples. Large increases in peel tissue content of α-farnesene observed in untreated fruit of both harvest dates in Golden Delicious and Imperial cultivars. 1-MCP strongly decreased α-farnesene and conjugated trienols accumulation in treated fruit peel tissues at both maturity stages of two cultivars during storage. The results confirm the proposed role of Ctols in scald induction and indicate that α-farnesene production is strongly regulated by ethylene. Conclusion: In general, we conclude that only α-farnesene synthesis and its oxidation products (Ctols) levels in peel tissue could not be involved to the inherent nature of scald susceptibility or resistance in two cultivars tested.
Apple fruit, α-farnesene, Conjugated trienoles, Superficial scald, Cultivar difference
Apple fruit, α-farnesene, Conjugated trienoles, Superficial scald, Cultivar difference
99
109
http://jmp.ir/browse.php?a_code=A-10-241-2&slc_lang=en&sid=1
2009/05/52009/05/112009/04/212009/05/52009/04/112009/04/112009/05/252009/05/242009/04/52009/06/132009/06/162009/04/202009/03/11
1387/12/21
2009/07/42009/06/272009/05/272009/08/102009/06/132009/05/242009/08/242009/07/132009/06/152009/08/262009/08/242009/06/152009/06/3
1388/3/13
M
Shekarchi
Food and Drug Control Laboratories and Food and Drug Laboratory Research Center, MOH & ME
M
Shekarchi
00319475328460038297
00319475328460038297
No
Food and Drug Control Laboratories and Food and Drug Laboratory Research Center, MOH & ME
R
Naghshiband Hassani
Department of Horticultural Sciences, Faculty of Agriculture, University of Tabriz
R
Naghshiband Hassani
00319475328460038298
00319475328460038298
No
Department of Horticultural Sciences, Faculty of Agriculture, University of Tabriz
Y
Mostofi
Department of Horticultural Sciences, College of Agriculture and Natural Resources, University of Tehran
Y
Mostofi
00319475328460038299
00319475328460038299
No
Department of Horticultural Sciences, College of Agriculture and Natural Resources, University of Tehran
Z
Zamani
Department of Horticultural Sciences, College of Agriculture and Natural Resources, University of Tehran
Z
Zamani
00319475328460038300
00319475328460038300
No
Department of Horticultural Sciences, College of Agriculture and Natural Resources, University of Tehran
M
Pirali Hamedani
Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences and Medicinal Plants Research Center and Food and Drug Laboratory Research Center, MOH & ME
M
Pirali Hamedani
m.pirali@fdo.ir
00319475328460038301
00319475328460038301
Yes
Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences and Medicinal Plants Research Center and Food and Drug Laboratory Research Center, MOH & ME
en
Antidermatophyte Activity of the Essential oil of Hypericum perforatum of North of Iran
Antidermatophyte Activity of the Essential oil of Hypericum perforatum of North of Iran
Background: Dermatophytes are the main cause of human superficial mycosis that is still a public health problem especially in tropical countries such as Iran. Objective: The aim of this study was determining the antifungal effect of Hypercom perforatum essential oil. Methods: The minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) for the essential oil of the plant Hypericum perforatum against various dermatophytes were determined. The essential oil of Hypericum perforatum was obtained by hydro distillation of the dried plant. Clinical isolates of dermatophytes (Epidermophyton floccosum, Microsporum canis, Microsporum gypseum, T. mentagrophytes var. interdigital, T. mentagrophytes var. mentagrophytes., T. rubrum and Trichophyton tonsurans) were used for determining antifungal activity of this essential oil by in vitro tube dilution technique. Results: MIC90 and MFC90 values were remarkable. T. mentagrophytes var. interdigital showed a>1 log10 difference in viable count between treatment and control within the first hour, whereas E. floccosum did not. The essential oil of H. perforatum sufficiently inhibited and killed all tested dermatophytes in all different dilutions. The changes in growth curve of the treated dermatophytes were significant compared with the untreated dermatophytes. Conclusion: Terpinen-4-ol is the main component of the essential oil of H. perforatum, and perhaps could play the important role in antidermatophyte activity among the other components. It is suggested trying the in-vivo effects of Hypericum perforatum ointment or its other medicinal forms in the treatment and controlling of dermatophytes infections.
Background: Dermatophytes are the main cause of human superficial mycosis that is still a public health problem especially in tropical countries such as Iran. Objective: The aim of this study was determining the antifungal effect of Hypercom perforatum essential oil. Methods: The minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) for the essential oil of the plant Hypericum perforatum against various dermatophytes were determined. The essential oil of Hypericum perforatum was obtained by hydro distillation of the dried plant. Clinical isolates of dermatophytes (Epidermophyton floccosum, Microsporum canis, Microsporum gypseum, T. mentagrophytes var. interdigital, T. mentagrophytes var. mentagrophytes., T. rubrum and Trichophyton tonsurans) were used for determining antifungal activity of this essential oil by in vitro tube dilution technique. Results: MIC90 and MFC90 values were remarkable. T. mentagrophytes var. interdigital showed a>1 log10 difference in viable count between treatment and control within the first hour, whereas E. floccosum did not. The essential oil of H. perforatum sufficiently inhibited and killed all tested dermatophytes in all different dilutions. The changes in growth curve of the treated dermatophytes were significant compared with the untreated dermatophytes. Conclusion: Terpinen-4-ol is the main component of the essential oil of H. perforatum, and perhaps could play the important role in antidermatophyte activity among the other components. It is suggested trying the in-vivo effects of Hypericum perforatum ointment or its other medicinal forms in the treatment and controlling of dermatophytes infections.
;lt,i;gt,Hypericum perforatum;lt,/i;gt,, Antidermatophyte activity
;lt,i;gt,Hypericum perforatum;lt,/i;gt,, Antidermatophyte activity
110
117
http://jmp.ir/browse.php?a_code=A-10-200-2&slc_lang=en&sid=1
2009/05/52009/05/112009/04/212009/05/52009/04/112009/04/112009/05/252009/05/242009/04/52009/06/132009/06/162009/04/202009/03/112009/03/12
1387/12/22
2009/07/42009/06/272009/05/272009/08/102009/06/132009/05/242009/08/242009/07/132009/06/152009/08/262009/08/242009/06/152009/06/32009/06/6
1388/3/16
M
Larypoor
Department of veterinary Mycology, Faculty of veterinary, Science and research branch Azad Islamic university
M
Larypoor
00319475328460038302
00319475328460038302
No
Department of veterinary Mycology, Faculty of veterinary, Science and research branch Azad Islamic university
A
Akhavansepahy
Department of Microbiology, North Branch of Islamic Azad University
A
Akhavansepahy
00319475328460038303
00319475328460038303
No
Department of Microbiology, North Branch of Islamic Azad University
N
Rahimifard
Food and Drug Control Laboratories and Food and Drug Laboratory Research Center, MOH
N
Rahimifard
rahimif@fdo.ir
00319475328460038304
00319475328460038304
Yes
Food and Drug Control Laboratories and Food and Drug Laboratory Research Center, MOH
H
Rashedi
Department of Biotechnology, School of Engineering, College of Engineering, University of Tehran (UT),
H
Rashedi
00319475328460038305
00319475328460038305
No
Department of Biotechnology, School of Engineering, College of Engineering, University of Tehran (UT),
en
Effects of Ginger on Spermatogenesis in Streptozotocin-induced Diabetic Rat
Effects of Ginger on Spermatogenesis in Streptozotocin-induced Diabetic Rat
Background: Ginger rhizome (Zingiber officinale R., family: Zingiberaceae) is used medicinally and as a culinary spice. The medicinal use of ginger dates back to ancient China and India. Objective: Ginger and its constituents are stated to have antiemetic, antithrombotic, antihepatotoxic, anti-inflammatory, stimulant, cholagogue and antioxidant.Enhanced oxidative stress and changes in antioxidant capacity are considered to play an important role in the pathogenesis of chronic diabetes mellitus. Methods: Wistar male rat (n=40) were allocated into three groups, control group (n=10) and ginger (G) group that received 100mg/kg-perday (oral), (n=10), and Diabetic group that received 55 mg/kg (IP) streptozotocin (STZ) (n=20) which was subdivided to two groups of 10 STZ group and treatment group. Treatment group received 55mg/kg (IP) STZ plus ginger 100mg/kg-perday (G), daily for, 4 weeks, respectively however, the control group just received an equal volume of distilled water daily(IP). Diabetes was induced by a single (IP) injection of streptozotocin (55 mg/kg). Animals were kept in standard condition. In 28day after inducing diabetic 5cc blood were collected for TAC, MDA and sperm parameters and testis tissues of Rat in whole groups were removed then prepared for analyzes. Results: TAC, MDA and sperm parameters significantly decreased in diabetic group.treatment groub that has received Ginger 100 mg/kg (oral) show increasing in TAC and sperm parameters (p<0.05) in comparison to experimental groups (p<0.05). Conclusion: Since in our study 100 mg/kg (oral) ginger have significantly Preventive effect on sperm parameters, so it seems that using it can be effective for treatment in Diabetic Rat.
Background: Ginger rhizome (Zingiber officinale R., family: Zingiberaceae) is used medicinally and as a culinary spice. The medicinal use of ginger dates back to ancient China and India. Objective: Ginger and its constituents are stated to have antiemetic, antithrombotic, antihepatotoxic, anti-inflammatory, stimulant, cholagogue and antioxidant.Enhanced oxidative stress and changes in antioxidant capacity are considered to play an important role in the pathogenesis of chronic diabetes mellitus. Methods: Wistar male rat (n=40) were allocated into three groups, control group (n=10) and ginger (G) group that received 100mg/kg-perday (oral), (n=10), and Diabetic group that received 55 mg/kg (IP) streptozotocin (STZ) (n=20) which was subdivided to two groups of 10 STZ group and treatment group. Treatment group received 55mg/kg (IP) STZ plus ginger 100mg/kg-perday (G), daily for, 4 weeks, respectively however, the control group just received an equal volume of distilled water daily(IP). Diabetes was induced by a single (IP) injection of streptozotocin (55 mg/kg). Animals were kept in standard condition. In 28day after inducing diabetic 5cc blood were collected for TAC, MDA and sperm parameters and testis tissues of Rat in whole groups were removed then prepared for analyzes. Results: TAC, MDA and sperm parameters significantly decreased in diabetic group.treatment groub that has received Ginger 100 mg/kg (oral) show increasing in TAC and sperm parameters (p<0.05) in comparison to experimental groups (p<0.05). Conclusion: Since in our study 100 mg/kg (oral) ginger have significantly Preventive effect on sperm parameters, so it seems that using it can be effective for treatment in Diabetic Rat.
Diabetic, Ginger rhizome, Streptozotocin, Sperm, Rat
Diabetic, Ginger rhizome, Streptozotocin, Sperm, Rat
118
124
http://jmp.ir/browse.php?a_code=A-10-186-4&slc_lang=en&sid=1
2009/05/52009/05/112009/04/212009/05/52009/04/112009/04/112009/05/252009/05/242009/04/52009/06/132009/06/162009/04/202009/03/112009/03/122009/05/11
1388/2/21
2009/07/42009/06/272009/05/272009/08/102009/06/132009/05/242009/08/242009/07/132009/06/152009/08/262009/08/242009/06/152009/06/32009/06/62009/06/20
1388/3/30
M
Nassiri
Department of Veterinary Pathology, Islamic Azad University Urumia Branch
M
Nassiri
00319475328460038306
00319475328460038306
No
Department of Veterinary Pathology, Islamic Azad University Urumia Branch
A
Khaki
Department of Veterinary Pathology (YRC), Islamic Azad University Tabriz Branch
A
Khaki
00319475328460038307
00319475328460038307
No
Department of Veterinary Pathology (YRC), Islamic Azad University Tabriz Branch
HR
Ahmadi-Ashtiani
Department of Clinical Biochemistry, School of Medical Science, Tarbiat Modarres University, Tehran, Iran; Biochemistry & Nutrition Department of Zanjan Medical University
HR
Ahmadi-Ashtiani
00319475328460038308
00319475328460038308
No
Department of Clinical Biochemistry, School of Medical Science, Tarbiat Modarres University, Tehran, Iran; Biochemistry & Nutrition Department of Zanjan Medical University
Sh
Rezazadeh
Institute of Medicinal Plants, ACECR, Tehran
Sh
Rezazadeh
shrezazadeh@yahoo.com
00319475328460038309
00319475328460038309
Yes
Institute of Medicinal Plants, ACECR, Tehran
H
Rastgar
Ministry of Health and Medical Education, Food & Drug Laboratory Research center,
H
Rastgar
00319475328460038310
00319475328460038310
No
Ministry of Health and Medical Education, Food & Drug Laboratory Research center,
Sh
Gharachurlu
Department of Veterinary Pathology (YRC), Islamic Azad University Tabriz Branch
Sh
Gharachurlu
00319475328460038311
00319475328460038311
No
Department of Veterinary Pathology (YRC), Islamic Azad University Tabriz Branch
en
Studies on GC/MS Spectroscopic Analysis of some Bioactive Antimicrobial Compounds from Cinnamomum zeylanicum
Studies on GC/MS Spectroscopic Analysis of some Bioactive Antimicrobial Compounds from Cinnamomum zeylanicum
Background: Infectious diarrhoea is an emergent problem in both developing and developed countries for high rates of mortality in infants. In recent years, drug resistance to microbial pathogens has been commonly reported from all over the world. Medicinal plants represent a rich source of antimicrobial agents. Plants are used medicinally in different countries especially in India and are a source of many potent and powerful drugs. This study was aimed to explore the bioactive antimicrobial compounds present in Cinnamon zeylanicum, which is used as a spice in Indian foods. Objective: The aim of this study was to carry out Gas chromatography and Mass spectroscopy studies and to determine the antimicrobial activity of Cinnamon zeylanicum extract against some common microbial pathogens isolated from diarrhoeal patients. Methods: The extract was prepared by the method of maceration using methanol as extraction solvent. The antimicrobial activity was performed by disc diffusion method at the concentration 200, 100, 50, 25 and 10 mg/ml against E. coli, Salmonella typhi, Salmonella typhimurium, Shigella dysenterae, Shigella flexneri, Pseudomonas aeruginosa and Klebsiella pneumonia and the fungi Candida albicans, Candida tropicalis, Candida krusei which are isolated from the paediatric diarrhoeal samples. Gas chromatography and Mass spectroscopy studies were performed to identify the bioactive compounds. Results: The methanol extract was found very sensitive against all the isolated organisms. The preliminary phytochemical screening shows the presence of carbohydrate, glycosides, phenolic compounds, tannins, terpenes and proteins. The GC/MS study on the active principles shows the presence of 38 components. Conclusion: This study shows that the Cinnamon zeylanicum extract exhibit high antifungal activity as compared with antibacterial activity. The most identified compound by GC/MS to have antimicrobial property were monoterpenes, sesquiterpenes, aromatic aldehydes and ketones. Cinnamaldehyde was the major compound responsible for the antimicrobial activity.
Background: Infectious diarrhoea is an emergent problem in both developing and developed countries for high rates of mortality in infants. In recent years, drug resistance to microbial pathogens has been commonly reported from all over the world. Medicinal plants represent a rich source of antimicrobial agents. Plants are used medicinally in different countries especially in India and are a source of many potent and powerful drugs. This study was aimed to explore the bioactive antimicrobial compounds present in Cinnamon zeylanicum, which is used as a spice in Indian foods. Objective: The aim of this study was to carry out Gas chromatography and Mass spectroscopy studies and to determine the antimicrobial activity of Cinnamon zeylanicum extract against some common microbial pathogens isolated from diarrhoeal patients. Methods: The extract was prepared by the method of maceration using methanol as extraction solvent. The antimicrobial activity was performed by disc diffusion method at the concentration 200, 100, 50, 25 and 10 mg/ml against E. coli, Salmonella typhi, Salmonella typhimurium, Shigella dysenterae, Shigella flexneri, Pseudomonas aeruginosa and Klebsiella pneumonia and the fungi Candida albicans, Candida tropicalis, Candida krusei which are isolated from the paediatric diarrhoeal samples. Gas chromatography and Mass spectroscopy studies were performed to identify the bioactive compounds. Results: The methanol extract was found very sensitive against all the isolated organisms. The preliminary phytochemical screening shows the presence of carbohydrate, glycosides, phenolic compounds, tannins, terpenes and proteins. The GC/MS study on the active principles shows the presence of 38 components. Conclusion: This study shows that the Cinnamon zeylanicum extract exhibit high antifungal activity as compared with antibacterial activity. The most identified compound by GC/MS to have antimicrobial property were monoterpenes, sesquiterpenes, aromatic aldehydes and ketones. Cinnamaldehyde was the major compound responsible for the antimicrobial activity.
Antimicrobial activity, ;lt,i;gt,Cinnamomum zeylanicum;lt,/i;gt,, Gas chromatography/Mass Spectroscopic Studies
Antimicrobial activity, ;lt,i;gt,Cinnamomum zeylanicum;lt,/i;gt,, Gas chromatography/Mass Spectroscopic Studies
125
131
http://jmp.ir/browse.php?a_code=A-10-240-1&slc_lang=en&sid=1
2009/05/52009/05/112009/04/212009/05/52009/04/112009/04/112009/05/252009/05/242009/04/52009/06/132009/06/162009/04/202009/03/112009/03/122009/05/112009/03/10
1387/12/20
2009/07/42009/06/272009/05/272009/08/102009/06/132009/05/242009/08/242009/07/132009/06/152009/08/262009/08/242009/06/152009/06/32009/06/62009/06/202009/07/27
1388/5/5
B
Uma
Research scholar, Division of Microbiology, Rajah Muthiah Medial College and Hospital, Annamalainagar -608001
B
Uma
amu_sri2003@yaho.co.in
00319475328460038312
00319475328460038312
Yes
Research scholar, Division of Microbiology, Rajah Muthiah Medial College and Hospital, Annamalainagar -608001
K
Prabhakar
Professor, Division of Microbiology, Rajah Muthiah Medial College and Hospital, Annamalai nagar -608001
K
Prabhakar
00319475328460038313
00319475328460038313
No
Professor, Division of Microbiology, Rajah Muthiah Medial College and Hospital, Annamalai nagar -608001
S
Rajendran
Professor, Division of Microbiology, Rajah Muthiah Medial College and Hospital, Annamalai nagar -608001
S
Rajendran
00319475328460038314
00319475328460038314
No
Professor, Division of Microbiology, Rajah Muthiah Medial College and Hospital, Annamalai nagar -608001
Y
Lakshmi Sarayu
Head of the Department, Division of Microbiology, Rajah Muthiah Medial College and Hospital, Annamalainagar -608001, Tamilnadu
Y
Lakshmi Sarayu
00319475328460038315
00319475328460038315
No
Head of the Department, Division of Microbiology, Rajah Muthiah Medial College and Hospital, Annamalainagar -608001, Tamilnadu
en
Study on Chemical Composition of Essential oil and Anti-oxidant and Anti Microbial Properties of Artemisia haussknechtii
Study on Chemical Composition of Essential oil and Anti-oxidant and Anti Microbial Properties of Artemisia haussknechtii
Background: Artemisia species with common Persian name of Dermaneh are found all over Iran and are used for treatment in infectious diseases such as malaria, hepatitis and other diseases. Some Artemisia species are used in traditionally as tonic and anti-helmintic in north of Iran. Objective: The aim of this study was to investigate chemical composition of the essential oil of Artemisia haussknechtii. Also potential antioxidant and anti microbial activities of the essential oil and ethanolic extract were studied. Methods: The essential oil was prepared by hydrodistillation and analyzed by GC and GC/MS instruments. Antioxidant activity was evaluated by methods namely DPPH, free radical scavenging, FTC system and total phenolic compounds analyzing. The antimicrobial activities of the extract were individually tested against a panel of microorganisms using disc diffusion method and MIC (minimum inhibitory concentration) measurement. Results: Forty-eight components were identified constituting 98.35 of total oil. Camphor (12.4%), α-Terpineol (9.93%), Davana ether (6/24%), and Bornyl acetate (3.77%) were the major components. Good antioxidant activity of extract increasing with the increment of concentration of plant extract was revealed. Ethanolic extract of Artemisia haussknechtii inhibited both gram- positive and gram- negative bacteria. MIC of the extract against yeast was the lowest (2.5 µg/ml). Conclusion: A known anti-bacterial compound (camphor) was one of major components in the essential oil, ethanolic extract showed good anti-oxidant activity and also extract inhibited growth of both gram positive and gram negative bacteria and fungi. These findings supported some traditional use of this plant.
Background: Artemisia species with common Persian name of Dermaneh are found all over Iran and are used for treatment in infectious diseases such as malaria, hepatitis and other diseases. Some Artemisia species are used in traditionally as tonic and anti-helmintic in north of Iran. Objective: The aim of this study was to investigate chemical composition of the essential oil of Artemisia haussknechtii. Also potential antioxidant and anti microbial activities of the essential oil and ethanolic extract were studied. Methods: The essential oil was prepared by hydrodistillation and analyzed by GC and GC/MS instruments. Antioxidant activity was evaluated by methods namely DPPH, free radical scavenging, FTC system and total phenolic compounds analyzing. The antimicrobial activities of the extract were individually tested against a panel of microorganisms using disc diffusion method and MIC (minimum inhibitory concentration) measurement. Results: Forty-eight components were identified constituting 98.35 of total oil. Camphor (12.4%), α-Terpineol (9.93%), Davana ether (6/24%), and Bornyl acetate (3.77%) were the major components. Good antioxidant activity of extract increasing with the increment of concentration of plant extract was revealed. Ethanolic extract of Artemisia haussknechtii inhibited both gram- positive and gram- negative bacteria. MIC of the extract against yeast was the lowest (2.5 µg/ml). Conclusion: A known anti-bacterial compound (camphor) was one of major components in the essential oil, ethanolic extract showed good anti-oxidant activity and also extract inhibited growth of both gram positive and gram negative bacteria and fungi. These findings supported some traditional use of this plant.
;lt,i;gt,Artemisia haussknechtii;lt,/i;gt,, Essential oil, Anti-oxidant, Anti microbial
;lt,i;gt,Artemisia haussknechtii;lt,/i;gt,, Essential oil, Anti-oxidant, Anti microbial
132
141
http://jmp.ir/browse.php?a_code=A-10-192-2&slc_lang=en&sid=1
2009/05/52009/05/112009/04/212009/05/52009/04/112009/04/112009/05/252009/05/242009/04/52009/06/132009/06/162009/04/202009/03/112009/03/122009/05/112009/03/102009/05/5
1388/2/15
2009/07/42009/06/272009/05/272009/08/102009/06/132009/05/242009/08/242009/07/132009/06/152009/08/262009/08/242009/06/152009/06/32009/06/62009/06/202009/07/272009/09/14
1388/6/23
M
Khanahmadi
Department of Chemistry, Kermanshah Branch of ACECR
M
Khanahmadi
chem_khanahmadi@yahoo.com
00319475328460038316
00319475328460038316
Yes
Department of Chemistry, Kermanshah Branch of ACECR
Sh
Rezazadeh
Institute of Medicinal Plants (ACECR), Karaj
Sh
Rezazadeh
00319475328460038317
00319475328460038317
No
Institute of Medicinal Plants (ACECR), Karaj
F
Shahrezaei
Department of Chemistry, Kermanshah Branch of ACECR, Kermanshah
F
Shahrezaei
00319475328460038318
00319475328460038318
No
Department of Chemistry, Kermanshah Branch of ACECR, Kermanshah
M
Taran
Department of Biology, Faculty of Science, Razi University, Kermanshah
Taran
00319475328460038319
00319475328460038319
No
Department of Biology, Faculty of Science, Razi University, Kermanshah