@article{ author = {Hasanzadeh, E and Rezazadeh, SH and Shamsa, SF and Dolatabadi, R and Zarringhalam, J}, title = {Review on phytochemistry and Therapeutic properties of Fenugreek (Trigonella foenum-graceum)}, abstract ={Fenugreek is an annual plant from leguminosea endemic to east Mediterranean. It has been used in traditional medicine for a while. It has been used for its oxytocic, digestive, and metabolism enhancement properties. While is reach in alkaloids, steroids, and sapogenins and also has good medicinal properties, it became one af more important medicinal plants. Nicotinic acid, and Trigonelline which are effective in treatment of diabetes and hypercholestremia, are reach in this plant. Also diosgenin, another medicinally important compound, is produced by this plant in high concentration. Many studies have been done and revealing it’s beneficial in treatment diabetes and other metabolic disorders. In this review, we summaries some of this studies.}, Keywords = {Fenugreek, Trigonelline, Diosgenin, Diabetes, Therapeutic properties}, volume = {9}, Number = {34}, pages = {1-18}, publisher = {Institute of Medicinal Plants, ACECR}, url = {http://jmp.ir/article-1-280-en.html}, eprint = {http://jmp.ir/article-1-280-en.pdf}, journal = {Journal of Medicinal Plants}, issn = {2717-204X}, eissn = {2717-2058}, year = {2010} } @article{ author = {Ahmadian-Attari, MM and Kamalinia, G and Mosaddegh, M and Farsam, H}, title = {A Comparative Study on Uterus and Kidney Inflammation and their Treatments Described in the Book “Hidayat al-Muta’allimin fit-Tib” with Modern Medicine}, abstract ={“Hidayat al-Muta’allimin fit-Tib” (A Guide to Students of Medicine) is one of the oldest Persian medical books written in Persian by Akhawayni around 11th century in Bukhara. In this book, each disease is described as a separate monograph including signs and symptoms as well as treatment orders. Two of the well explained monographs are concerned to inflammation of uterus and kidney. The purpose of this study was to compare the signs, symptoms, and treatment procedures written in the above mentioned book with what written in modern medical texts for Pelvic Inflammatory Disease (PID) and kidney abscess. For this purpose, a comparative study on signs, symptoms, and treatment procedures of these diseases with modern medicine was done. According to this study, the inflammation of uterus in primary stage showed some similarities with PID and in final stage with tubo- ovarian abscess. The inflammation of kidney at its first stage had a lot of resemblance with pyelonephritis, in advanced stage with interarenal or perinephric abscess, and in final stage with renal failure. The treatment procedures in the old traditional medicine were originally based on herbal treatments that are completely different with modern antibiotic therapy. However, the anti-inflammatory and anti-infective herbal drugs used in this book are in support of the antimicrobial and anti-inflammatory data reported for the most of these herbs in scientific literatures. The results point out that the ancient Iranian physicians had a reasonable concept of the infective diseases. The herbs used by traditional physicians have ethnopharmacological potential for further research to develop new antibacterial and anti-inflammatory agents from these plants.}, Keywords = {PID, Renal Abscess, Renal Inflammation, Renal Scar, Uteritis, Phytotherapy}, volume = {9}, Number = {34}, pages = {18-37}, publisher = {Institute of Medicinal Plants, ACECR}, url = {http://jmp.ir/article-1-281-en.html}, eprint = {http://jmp.ir/article-1-281-en.pdf}, journal = {Journal of Medicinal Plants}, issn = {2717-204X}, eissn = {2717-2058}, year = {2010} } @article{ author = {Karimi, N and Naderi, R and Ebrahimi, M and Mofid, MR}, title = {Investigation of a Medicinal and Ornamental Plant Propagation, the Cereus peruvianus Mill. and Using Tissue Culture Technique}, abstract ={Background: The extracted juice and alkaloeids of the medicinal and ornamental cactus Cereus peruvianus are contain a lot of effective compounds which widely use in medicine and agricultural industries. Propagation of this plant using conventional method (seed, cutting, offset) is very slow and its mass production is possible by tissue culture technique. Objective: The aim of this study was the micropropagation possibility and recognition of some of its different aspects, and determination of suitable medium and hormonal composition at in-vitro conditions of cereus. Methods: The experimental design was compeletly randomized with 3 replication and each replicate was contained 5 sample. After surface disinfection the explants were cultured on MS basal medium containing %3 sucrose,8 g/l phytoagar and different treatment of plant growth regulators (IBA, NAA, Kinetin, BAP, 2,4-D, GA3, TDZ) and pH=5/8. After 45 days, some parameters such as effectivness of culture media in percent of regeneration from areole, production of friable callus and rooting in all treatments were recorded. Results: In this research The best growth of friable callus was obtained in MS medium supplemented with 0.07mg/l TDZ and 0.05 mg/l NAA and 4mg/l 2,4-D with 6mg/l kinetin for regeneration of areole and 4mg/l 2,4-D and 4mg/l kinetin for rooting was the most favorable medium. High regeneration potential was observed after 2.5-3 months of culture. Eight different media was selected for plantlet regeneration. There is a significant difference between regeneration of areole in cereus peruvianus var monstrosus and cereus peruvianus var tortuosus. Conclusion: As for to the importance of the extracted juice and alkaloeids of the cactus Cereus peruvianus Propagation of this plant using by conventional method is very slow and propagation it of areol in addition to economical is very fast.}, Keywords = {<,i>,Cereus peruvianus<,/i>,, <,i>,Varite monstrosus<,/i>, and <,i>,tortuosus<,/i>,, Callus, Micropropagation}, volume = {9}, Number = {34}, pages = {38-45}, publisher = {Institute of Medicinal Plants, ACECR}, url = {http://jmp.ir/article-1-282-en.html}, eprint = {http://jmp.ir/article-1-282-en.pdf}, journal = {Journal of Medicinal Plants}, issn = {2717-204X}, eissn = {2717-2058}, year = {2010} } @article{ author = {Naderi, GA and Khalili, M and Karimi, M and Soltani, M}, title = {The Effect of Oral and Intraperitoneal Administration of Acorus calamus L. Extract on Learning and Memory in Male Rats}, abstract ={Background: Learning and memory impairment during aging mind have a disturbance role in human life. Regarding to the defect mechanisms for prevention or treatment of memory loss, the new strategies were recommended for study on it. Objective: Importance of herbal medicine treatment encouraged us to examine the effect of a candidate plant Acorus calamus for improvement of learning and memory. Methods: Male rats were randomly divided to control and treatment groups. In treatment group the plant were applied to animals in oral (plant/ food ratio = % 6.25) for two weeks and in injected groups the plant extract were applied (i.p) to rat in 25, 50 and 100 mg/kg). Finally, all experimental animal groups were conducted to Y maze and shuttle box tests in order to obtain spatial recognition and acquisition – recalling data, respectively. Results: The step through latency (STL) time resulted from oral and 100 mg/kg injected dose groups show a significant difference with control animals. Also, alternation behavior (%) obtained from Y maze test data was marked than control rats. Conclusion: The present study show that oral and intraperitoneal administration of the extract in higher dose could have increase spatial recognition and recalling the data,}, Keywords = {<,i>,Acorus calamus<,/i>, L, Learning and memory, Rat}, volume = {9}, Number = {34}, pages = {46-56}, publisher = {Institute of Medicinal Plants, ACECR}, url = {http://jmp.ir/article-1-283-en.html}, eprint = {http://jmp.ir/article-1-283-en.pdf}, journal = {Journal of Medicinal Plants}, issn = {2717-204X}, eissn = {2717-2058}, year = {2010} } @article{ author = {Kazemizadeh, Z and Habibi, Z and Moradi, A}, title = {Isolation β-Stigmasterol from Teucrium hyrcanicum L., growing wild in Gilan Province}, abstract ={Background: The genus Teucrium (Lamiaceae) is comprised 340 species in widespread over the world. Remarkably, In the Flora Iranica this genus is represented by twelve species, three of which are endemic. The genus Teucrium are known for medicinal value, antibacterial, antioxidant, anti-inflamatory, antiseptic and antipyretic properties. Objective: Isolation of β-Stigmasterol from Teucrium hyrcanicum L. Methods: The aerial parts of Teucrium hyrcanicum were collected during the flowering stage from Rostamabad, Gilan Province, in July 2006 and then were extracted by chloroform and acetone (2:1) for 36 h. Crude extract was separated by adsorption chromatography over silica gel with elution by petroleum and ethylacetate. Final purification was performed by smaller chromatography. Results: A steroid named β - Stigmasterol were isolated and the structur of them were proved using spectral data consist of FTIR, UV, HRMS, also 1-DNMR (1HNMR, 13CNMR), 2-DNMR (HMQC, HMBC) and DEPT (90°,135°). Conclusion: β-Stigmasterol was characterized for the first time in Teucrium hyrcanicum.}, Keywords = {<,i>,Teucrium hyrcanicum<,/i>,, Lamiaceae, <,i>,β<,/i>, - Stigmasterol}, volume = {9}, Number = {34}, pages = {67-73}, publisher = {Institute of Medicinal Plants, ACECR}, url = {http://jmp.ir/article-1-285-en.html}, eprint = {http://jmp.ir/article-1-285-en.pdf}, journal = {Journal of Medicinal Plants}, issn = {2717-204X}, eissn = {2717-2058}, year = {2010} } @article{ author = {Kiaei, E and Mazandarani, M and Ghaemi, E}, title = {Antibacterial Activity of 7 Species of Medicinal Plants on Bacteria Isolated from UTI Patients in Golestan Province}, abstract ={Background: Urinary tract infection (UTI) is extremely prevalent in the world. Despite treatment with antibiotics, recurrency is common in the patients and there is potential for developing antibiotic resistance. Objective: The aim of this study was to investigate the antibacterial activity of ethanolic extracts of 7 medicinal plants on pathogenic bacteria causing Urinary Tract Infection. Method: Plants were collected from their natural habitats in Golestan province (North of Iran). Antibacterial effects of ethanolic extracts were analyzed by disc diffusion method. Also the Minimum inhibitory concentration (MIC) of the extracts was determined by the microdilution Broth. Results: The results showed that Berberis vulgaris was the most effective extract with 29.4 mm diameter of inhibition zone on gram positive bacteria specially S. epidermidis. A. calcoaceticus, S. aereus, S. epidermidis, and S. saprophyticus were the most sensitive bacteria with maximum inhibition zone of 20.1, 26, 29.4, 28.5 mm, respectively. P. aeroginosa, C. freundii, K. pneumonia, and P. mirabilis were the most resistant bacteria in this research. Also extracts had better antibacterial effect in amount of 100 mg/ml. The lowest MIC values was measured in Berberis vulgaris with 0.09 mg/ml0 against S. epidermidis. Gram positive bacteria were more sensitive than gram negative bacteria. These plants in native’s traditional medicine have been used by rural people as antiseptic for the treatment of UTI. In addition, Our results showed that Berberis vulgaris and Hypericum perforatom were have strong antibacterial effects. Conclusion: In addition to Traditional uses of these plants in Golestan province for the treatment of UTI symptoms, invitro evaluation and clinical trials for their effects to treat UTI is suggested for future research.}, Keywords = {Antibacterial activity, Golestan province, Medicinal plant, Urinary Tract Infection}, volume = {9}, Number = {34}, pages = {74-83}, publisher = {Institute of Medicinal Plants, ACECR}, url = {http://jmp.ir/article-1-286-en.html}, eprint = {http://jmp.ir/article-1-286-en.pdf}, journal = {Journal of Medicinal Plants}, issn = {2717-204X}, eissn = {2717-2058}, year = {2010} } @article{ author = {Olfati, F and Azarbaijani, S and Hadizadeh, M and Sadeghi, T and Hajseiedjavadi, E}, title = {Effect of Powder of Stachys lvandulifolia Flowers on Primary Dysmenorrhea}, abstract ={Background: Because of importance and outbreak of dysmenorrhea and that’s effect on life of 50% populations in the world (women), this study was done. Objective: This study was performed to evaluate therapeutic effects of Stachys lvandulifolia on primary dysmenorrhea in 18 - 25 years old women. Methods: This research was a double - blind randomized clinical trial, that had been done on 50 women in 18 - 25 years old and 50 - 60 kg in weight that suffering from primary dysmenorrhea. Intensity of pain was evaluated by visual analog scale (VAS). Stachys lvandulifolia was given them as a traditional method. Such as 10g of powder of stachys flowers, three times a day, for 5 days (2 days before pain up to 3 days after pain). Then they were followed up for three cycles. Duration and intensity of pain and side effect of drugs was evaluated after utilization. Statistical analysis was performed using t-test, chi-square. Results: After Utilization, duration of pain was statistically significant (p=0/000). Conclusion: It can be concluded that the use of Stachys lvandulifolia on traditional method is effective in curing primary dysmenorrhea and it has no side effects resulting. In addition, it is effective on pattern of pain and increases tolerance.}, Keywords = {Primary dysmenorrhea, <,i>,Stachys lvandulifolia<,/i>,, Pain}, volume = {9}, Number = {34}, pages = {84-89}, publisher = {Institute of Medicinal Plants, ACECR}, url = {http://jmp.ir/article-1-287-en.html}, eprint = {http://jmp.ir/article-1-287-en.pdf}, journal = {Journal of Medicinal Plants}, issn = {2717-204X}, eissn = {2717-2058}, year = {2010} } @article{ author = {Haeri, MR and Shams-Ardakani, MR and Rahbani, M and Izaddust, M and Khanavi, M}, title = {Quantification of 4-hydroxyisoleucine content in treated and untreated Fenugreek seeds using GC}, abstract ={Background: There are some reports regarding antidiabetic activity of 4-hydroxyisoleucine, however its hypoglycemic property must be proven completely before presentating as a new drug. Preparing suitable amount of 4-hydroxyisoleucine is nesessary for supporting in vivo studies. Objective: The purpose of the present study was isolation of 4-hydroxyisoleucine, comparing 4-hydroxyisoleucine content in two samples of Fenugreek seeds collected form two distinct parts of Iran and finally the effect of germination and supplementation by isoleucine on 4-hydroxyisoleucine yield. Methods: 4-hydroxyisoleucine was successfully isolated passing seed amino acid extract through ion exchange and silica gel column and then crystallization on methanol. 4-hydroxyisoleucine content in various samples was assessed by GC. Results: Seeds from Northwestern of Iran had higher amount of 4-hydroxyisoleucine in comparison to Central Iran. Furthermore yields from germinating seeds were 2 folds higher than the dried seeds, and could be increased 6 fold by inclusion of isoleucine supplement in the irrigation water. Conclusion: simple procedures can be engaged for improving yields of 4-hydroxyisoleucine isolated from fenugreek up to six-fold by using of germinated seeds supplemented with isoleucine.}, Keywords = {4-hydroxyisoleucine, Fenugreek seed, GC}, volume = {9}, Number = {34}, pages = {90-94}, publisher = {Institute of Medicinal Plants, ACECR}, url = {http://jmp.ir/article-1-288-en.html}, eprint = {http://jmp.ir/article-1-288-en.pdf}, journal = {Journal of Medicinal Plants}, issn = {2717-204X}, eissn = {2717-2058}, year = {2010} } @article{ author = {Hosseinzadeh, H and Ramezani, M and Akhtar, Y and Ziaei, T}, title = {Effects Boswellia carterii Gum Resin Fractions on Intact Memory and Hyoscine-induced Learning Impairments in Rats Performing the Morris Water Maze Task}, abstract ={Background: In traditional medicine, a gum resin obtained from Boswellia carterii, has been used as an agent for enhancing memory and learning abilities. Objective: In the present research, the effect of fractions obtained from gum resin of Boswellia carterii was assessed on enhancement of memory in intact and on memory impairments induced in rats by hyoscine using the Morris water maze task. Methods: The ethyl acetate (0.1 mg/kg) and N-butanol (0.1 mg/kg) fractions were injected intraperitoneally to rats 1 h before training for 5 consecutive days. During the training period, four trials were carried out each day. On the 5th day of the experiment, the locomotor activity was assessed using open field test. The effect of ethyl acetate fractions was evaluated on memory impairment induced by hyoscine (0.5 mg/kg). Results: The ethyl acetate (0.1 mg/kg) and N-butanol (0.1 mg/kg) fractions showed significant effects in enhancing the memory ability in intact rats. This effect was much significant with ethyl acetate fraction (p<0.001). The ethyl acetate (0.1 mg/kg) fraction reduced the deficit effect of hyoscine on memory (p<0.001). The N-butanol and ethyl acetate fractions (0.1 g/kg) have no effect on locomotor activity. Conclusion: On the basis of these results, B. carterii gum resin improved intact memory and the hyoscine impaired acquisition/performance activity. This effect may be mediated via cholinergic system.}, Keywords = {<,i>,Boswellia carterii<,/i>,, Learning and memory, Morris water maze, Hyoscine}, volume = {9}, Number = {34}, pages = {95-101}, publisher = {Institute of Medicinal Plants, ACECR}, url = {http://jmp.ir/article-1-289-en.html}, eprint = {http://jmp.ir/article-1-289-en.pdf}, journal = {Journal of Medicinal Plants}, issn = {2717-204X}, eissn = {2717-2058}, year = {2010} } @article{ author = {Ghanavati, M and Houshmand, SL and Zainali, H and Abrahimpour, F}, title = {Chemical Composition of the Essential Oils of Matricaria recutita L. Belonging to Central and South Parts of Iran}, abstract ={Background: Chamomile (Matricaria recutita L.) is one of the important and ancient well-documented medicinal plants in the World. Origin of Chamomile plant species is determined in the Frontal Asia Gene Pool Centre, mainly Iran. Objective: The objectives of this research are to individuate the results of the Chemical Composition of the Chamomile Essential Oils that is originated from geographical various parts of center and south the Iranian country. Methods: In this research 9 chamomile flower samples belonging central parts and south of Iran (Tehran, Isfahan, Shiraz, Kerman belong central parts, Gachsaran, Baba Meydan, Noor Abad, Behbahan and Larestan belong south of Iran) collected during 2006 spring and analyzed qualitative-quantitative characteristics of Essential oil by GC/Ms method. Results: One population belonging to the South of Iran (The Zagros Mountains) was rich in α- Bisabolol (55-58%) but had low content of the essential oil. Samples from Baba Mydan and Noor abad were rich in α- Bisabololoxide (50-60%). Conclusion: This Chamomile biodiversity was created during long time process (evolution) in regard to evaluate the influence of eco-physiological conditions (biotic- and abiotic- factors) on the concrete place of chamomile population growth.}, Keywords = {<,i>,Matricaria recutita<,/i>, L, Biodiversity, Composition, Essential oil}, volume = {9}, Number = {34}, pages = {102-108}, publisher = {Institute of Medicinal Plants, ACECR}, url = {http://jmp.ir/article-1-290-en.html}, eprint = {http://jmp.ir/article-1-290-en.pdf}, journal = {Journal of Medicinal Plants}, issn = {2717-204X}, eissn = {2717-2058}, year = {2010} } @article{ author = {Moosavy, MH and Basti, AA and Misaghi, A and Jabbari-Khamaneh, H and Karim, G and ZahraeiSalehi, T}, title = {Survey The of Effect of Zataria multiflora Boiss. Essential Oil on the Growth of Salmonella typhimurium in a Commercial Barley Soup}, abstract ={Background: In spite of done improvements in slaughter hygiene and food production techniques, food safety is an important public health issue. Furthermore, the World Health Organization has recently called for a worldwide reduction in the consumption of salt in order to reduce the incidence of cardio-vascular disease. If the level of salt in processed foods is reduced, it is possible that other additives will be needed to maintain the safety of foods. Essential oils are probably one of the natural additives that can use as antibacterial additives. Objective: The aim of this study was evaluation of the effect of Zataria multiflora Boiss. essential oil on the growth of Salmonella typhimurium in commercial barley soup. Methods: At first, essential oil of Zataria multiflora Boiss. analyzed using GC/MS and the chemical components were identified. Antibacterial activity of Zataria multiflora Boiss. essential oil on the growth of Salmonella typhimurium in commercial barley soup evaluated by using different essential oil concentrations (0.0, 0.005, 0.015 and 0.03%) and two different temperatures (8 and 25°c) during 21 days. Results: Antibacterial activity of Zataria multiflora Boiss. essential oil on the growth of Salmonella typhimurium was statistically significant (p<0.001). The correlation coefficient of essential oil with log10 of the number of Salmonella typhimurium was -0.402. Conclusion: Zataria multiflora Boiss. essential oil probably can used as a proper preservative against some food borne pathogen bacteria in certain foods.}, Keywords = {Essential oil, <,i>,Zataria multiflora<,/i>, Boiss., <,i>,Salmonella typhimurium<,/i>,, Barley soup}, volume = {9}, Number = {34}, pages = {109-116}, publisher = {Institute of Medicinal Plants, ACECR}, url = {http://jmp.ir/article-1-291-en.html}, eprint = {http://jmp.ir/article-1-291-en.pdf}, journal = {Journal of Medicinal Plants}, issn = {2717-204X}, eissn = {2717-2058}, year = {2010} } @article{ author = {AkhavanAmjadi, M and Zahrani, Sh and Mojab, F and AlaviMajd, H}, title = {Efficacy of Foeniculum vulgare Mill Extract on Menstrual Bleeding over the Students of Shahid Beheshti University in Tehran 2005}, abstract ={Background: Menstrual bleeding is a reaction of periodic falling secretary endometrial for the reason that decreases production of estradiol and progesterone. In traditional medicine, Foeniculum vulgare Mill is used as a tonic, sedative, galactogogue drug and increases menstrual bleeding. Objective: This study aimed to determine efficacy of Foeniculum vulgare Mill extract on menstrual bleeding severity and duration over the students of Shahid Beheshti University in Tehran 2005. Methods: This study was done as a placebo-control, double blind, randomized clinical trial. Bleeding severity and duration was assessed at baseline and throughout two menstrual cycle of the investigation using validated questionnaires. Ninety women, completed the study (n=46 treatment group, n=44 placebo group). The medicines capsules containing 46mg of Foeniculum vulgare Mill extract in treatment group, and same shape placebo capsules in placebo group, administered as soon as onset of pain feeling or bleeding, five capsules a day and continued for at least three days. Results: The data analysis with repeated measurements showed that after treatment in none of groups, average of menstrual bleeding severity and duration in comparison with before the treatment did not increase and there was no significant difference between two groups. Conclution: This study suggested that Foeniculum vulgare extract and placebo do not increase menstrual bleeding severity and duration. Studies showed that Foeniculum vulgare essential oil has ability to inhibit uterus contractions and increase menstrual bleeding, but this study showed that the extract had no effect on menstrual bleeding.}, Keywords = {<,i>,Foeniculum vulgare<,/i>,, Menstrual bleeding severity, Duration}, volume = {9}, Number = {34}, pages = {117-123}, publisher = {Institute of Medicinal Plants, ACECR}, url = {http://jmp.ir/article-1-292-en.html}, eprint = {http://jmp.ir/article-1-292-en.pdf}, journal = {Journal of Medicinal Plants}, issn = {2717-204X}, eissn = {2717-2058}, year = {2010} } @article{ author = {Valadi, A and Nasri, S and Abbasi, N and Amin, GR}, title = {Antinociceptive and Anti-inflammatory Effects of Hydroalchoholic Extract of Anethum graveolens L. seed}, abstract ={Background: There are many reports about anti-inflammatory effect of Anethum graveolens L.(A.g) in Iranian traditional medicine. In current decade, based on using of neutriceuticales for healing, the use of herbal drugs became very common. Objective: In this study, regarding the mentioned purposes, we have evaluated anti-inflammatory and antinociceptive effects of Hydroalchoholic Extract of A.g seeds. Methods: In this research, male mice were used and in inflammatory test they were divided to 6 groups: control, dexamethasone (15 mg/kg), seed A.g. extract (100,200, 400,500mg/kg). All of the drugs were administered intraperitonally. The inflammation was caused by xylene-induced ear oedema. In order to evaluate the antinocicetive of Anethum graveolens L. seed, we used formalin test. Mice were divided to 6 groups: control, seed A.g. extract (100,200, 400, 500 mg/kg). All of drugs were administered intraperitonally. Results: The results indicated that A.g. extract has anti-inflammatory and antinociceptive effects. Conclusion: This study suggests A.g extract as a candidate for pain relieving for further studies.}, Keywords = {<,i>,Anethum graveolens<,/i>, L. seed, Inflammation, Nociception, Xylene-induced ear oedema, Formalin test}, volume = {9}, Number = {34}, pages = {124-130}, publisher = {Institute of Medicinal Plants, ACECR}, url = {http://jmp.ir/article-1-293-en.html}, eprint = {http://jmp.ir/article-1-293-en.pdf}, journal = {Journal of Medicinal Plants}, issn = {2717-204X}, eissn = {2717-2058}, year = {2010} } @article{ author = {Sadeghi, E and AkhondzadehBasti, A and Misaghi, A and ZahraiiSalehi, T and BohlouliOsgoii, S}, title = {Evaluation of effects of Cuminum cyminum and Probiotic on Staphylococcus aureus in Feta Cheese}, abstract ={Background: Cuminum cyminum is one of the Iranian traditional spices and it has antimicrobial effect on the pathogenic bacteria which are agents for some current food born intoxications. Probiotics have known as health and immune system booster. Objective: Evaluation of antimicrobial effect of mentioned plant essential oil in combination with lactobacillus acidophilus on Staphylococcus aureus in Feta cheese. Methods: The essential oil of this plant was obtained by hydrodistillation and analyzed by GC/MS. Effects of different concentrations of this essential oil and lactobacillus acidophilus on Staphylococcus aureus were determined by evaluation of the microorganism growth on the selective media in laboratory, and these were took place in Feta cheese. Results: Results indicated that 0.03 and 0.015 percent of this essential oil have had the highest inhibitory effect on the growth of Staphylococcus aureus and when the mentioned concentrations of the essential oil were used in combination with lactobacillus acidophilus, the counts of the pathogen were decreased significantly bellow its toxic dose in this kind of food product. Results indicated that each one of mentioned concentrations of the essential oil and lactobacillus acidophilus, was significant. The synergistic impact between mentioned concentrations of the essential oil and lactobacillus acidophilus was significant. Conclusion: The antimicrobial effect of Cuminum cyminum in 0.03 percent was higher than its lesser concentrations and with concern to the control group, the synergistic effect between the probiotic and the essential oil is necessary to achieve this inhibitory effect.}, Keywords = {<,i>,Cuminum cyminum<,/i>,, Probiotic, <,i>,Staphylococcus aureus<,/i>,, Cheese}, volume = {9}, Number = {34}, pages = {131-141}, publisher = {Institute of Medicinal Plants, ACECR}, url = {http://jmp.ir/article-1-294-en.html}, eprint = {http://jmp.ir/article-1-294-en.pdf}, journal = {Journal of Medicinal Plants}, issn = {2717-204X}, eissn = {2717-2058}, year = {2010} } @article{ author = {Teimoori, M and Montaserkouhsari, Sh and Ghafarzadegan, R and Hajiaghaee, R}, title = {Antidiabetic Effects of Juglans regia Leave’s Methanolic Extract on Alloxan-induced Male Wisrar Rats}, abstract ={Background: Juglans regia leaves have antioxidant effects and have been used in Iranian traditional medicines for its hypoglycaemic properties in the treatment of diabetes. Objective: This study is designed to evaluate the antidiabetic effects of Juglans regia leave’s methanolic extract (JRLME). Methods: Alloxan-induced diabetic male wistar rats have treated with JRLME at doses of 250 mg/kg and 500 mg/kg for three weeks and its effects investigated on various biochemical parameters such as postprandial blood glucose level (short term and long term treatment by JRLME), oral glucose tolerance, Total cholesterol (TC), Triglyceride (TG), LDL-cholesterol, HDL-cholesterol and VLDL levels, enzymatic activities of superoxide dismutase (SOD), glutathione peroxidase (GPX) and catalase (CAT) using commercial kits. Results: The obtained results showed a decrease (31%) in the blood glucose level within 3 to 8 hours and also a significant decrease (44%) at the end of three weeks of feeding JRLME. The JRLME also decreased markedly TG (14%) and TC (7.6%) levels in blood serum. In addition, antioxidant effect of JRLME was determined from elevated GPX, SOD and CAT activities by 22, 12 and 9%, respectively, as compared to diabetic control group (DC). However, the data about CAT activity was not significant as compared to diabetic control group (DC). Conclusion: We concluded that Juglans regia leaves have multifunctional ameliorating effects in diabetic metabolic conditions.}, Keywords = {<,i>,Juglans regia<,/i>,, Blood Glucose, Total cholesterol, Antioxidant}, volume = {9}, Number = {34}, pages = {142-149}, publisher = {Institute of Medicinal Plants, ACECR}, url = {http://jmp.ir/article-1-295-en.html}, eprint = {http://jmp.ir/article-1-295-en.pdf}, journal = {Journal of Medicinal Plants}, issn = {2717-204X}, eissn = {2717-2058}, year = {2010} } @article{ author = {Tavakolifar, B and Rezazadeh, Sh and NaghdiBadi, H and Akhondzadeh, S and Heidari, M and Aghamohamadi, E}, title = {The Study of Arnebia (Arnebia euchroma (Royle) I. M. Johnst) Solution Effectiveness on the Treatment of Acne vulgaris}, abstract ={Background: Acne vulgaris, a common skin disease, is a chronic inflammation of the pilocebaceous units these areas include the face, the upper part of the chest, and the back. Antibiotices that inhibit “propionibacterium acne” are the selective treatment for acne. Now, because of antibiotic resistant, treatment is less effective. Therefore finding the alternative cure is nessesary. Objectives: The goal of this study is the comparison of arnebia solution effect with placebo on the treatment of mild to moderate acne. Methods: This study has been designed as double blined clinical trial on 68 patients with mild to moderate acne. The patients were divided in two groups. Pregnant and milk-feeding women,childeren with the age less than 12 years and patients that received related drugs to acne have been excluded from this study .The groups were treated topically with arnebia and placebo solution two times per day for 8 weeks. The inflammatory and non inflammatory lesions and the side effects were assessed in both groups. Results: These finding show that the arnebia solution was decreased the inflammatory signs, significantly (p<0.001). In this period of time no adverse effect was seen. Conclusion: In conclusion the arnebia solution was effective in the treatment of mild to moderate acne.}, Keywords = {Arnebia, <,i>,Acne vulgaris<,/i>,, Medicinal plants}, volume = {9}, Number = {34}, pages = {150-155}, publisher = {Institute of Medicinal Plants, ACECR}, url = {http://jmp.ir/article-1-302-en.html}, eprint = {http://jmp.ir/article-1-302-en.pdf}, journal = {Journal of Medicinal Plants}, issn = {2717-204X}, eissn = {2717-2058}, year = {2010} } @article{ author = {AhmadiAshtiani, HR and Allameh, A and Hamidipour, N and Rastegar, H and Soleimani, M}, title = {Increasing Rate of Human Bone Marrow Mesenchymal Stem Cell Proliferation in the Presence of Silymarin}, abstract ={Background: Mesenchymal stem cells (MSCs), the non-hematopoietic progenitor cells found in various adult tissues are characterized by their ease of isolation and their rapid growth in vitro while maintaining their differentiation potential, allowing for extensive culture expansion to obtain large quantities suitable for therapeutic application. Silymarin has strong antioxidant and anti-inflammatory activities with positive effect on proliferation on some cell types. Objectives: The aim of this study was to find out the optimal condition of silymarin treatments on mesenchymal stem cell growth and multiplication. Methods: Human MSCs in third passage were divided into 12 groups treated by 50, 75, and 100 μg/ml of silymarin for 2, 7 and 14 days. Cell viability was assayed on day 2 using trypan blue exclusion test. The cell proliferation rate in presence of silymarin was determined using a day-response curve for each dose. Results: Viability was 89%, 93%, and 96% for cells treated with 50, 75, and 100µg/ml silymarin, respectively. Cell viability showed significant increase in all treated cells in comparison with the control group (83%). Based on the day- response curve, it was shown that the rate of cell proliferation in treated cells is significantly higher when exposed to silymarin for 2 - 7 days. However, from 7th day to 14th, silymarin exposure lowers hBMSCs proliferation rate compared to control group. Conclusion: Under optimal condition of silymarin exposure time, the rate of MSC proliferation can be stimulated.}, Keywords = {Silymarin, Human bone marrow mesenchymal stem cell, Proliferation, Viability}, volume = {9}, Number = {34}, pages = {156-164}, publisher = {Institute of Medicinal Plants, ACECR}, url = {http://jmp.ir/article-1-303-en.html}, eprint = {http://jmp.ir/article-1-303-en.pdf}, journal = {Journal of Medicinal Plants}, issn = {2717-204X}, eissn = {2717-2058}, year = {2010} } @article{ author = {Tekieh, E and Rezazadeh, Sh and Manaheji, H and Akbari, A and Zaringhalam, J}, title = {The Effects of Pretreatment with Achillea santolina and Stachys athorecalyx Extracts on CFA-induced acute inflammation in male rats}, abstract ={Background: Inflammatory symptoms, hyperalgesia and edema, as a physiologic responses for stimulus can mediate via different mediators such as cytokines. Medicinal plants are an important source of substances which are claimed to induce anti-inflammatory effects. Objective: Regarding to these and on account of the Interlukine-6 roles in hyperalgesia and edema induction, the aim of this study explained to investigation of the pre-treatment effects of Achillea santolina and Stachys athorecalyx extracts on inflammation which induced by CFA in male Wistar rats. Methods: Methanolic and defatted extractions were done on aerial parts of the both plants: Achillea santolina and Stachys athorecalyx. 50, 100 and 200 mg/kg doses of extracts were selected for treatment. Results: Results indicated that pre-treatment with defatted and methanolic extracts of S. athorecalyx significantly decrease CFA-induced hyperalgesia and edema dose-dependently. At same situation only methanolic extract of A. santolina was effective in inflammatory signs reduction. Conclusion: It can concluded that A. santolina and S. athorecalyx extracts can be effective candidate for pre-treatment of inflammation, but the effective substances of them are different and need to be more investiged.}, Keywords = {Hyperalgesia, Inflammation, <,i>,Achillea santolina<,/i>,, <,i>,Stachys athorecalyx<,/i>,, Extract, CFA}, volume = {9}, Number = {34}, pages = {165-176}, publisher = {Institute of Medicinal Plants, ACECR}, url = {http://jmp.ir/article-1-304-en.html}, eprint = {http://jmp.ir/article-1-304-en.pdf}, journal = {Journal of Medicinal Plants}, issn = {2717-204X}, eissn = {2717-2058}, year = {2010} } @article{ author = {Jamshidi, M and Ahmadi-Ashtiani, HR and Rezazadeh, Sh and Fathiazad, F and Mazandarani, M and Khaki, A}, title = {Study on Phenolics and Antioxidant Activity of some Selected Plant of Mazandaran Province}, abstract ={Background: Plants are rich in phenolics (phenolic acids, flavonoids and Tannins). The interest in phenolics has been increased by recent reports of their antioxidant activities. These antioxidant nutrients from food sources reduce the harmful effects of oxidative stress and offer health advantages. Objective: Total phenolics, flavonoids contents and antioxidant capacity of seven culinary plants of Mazandaran province were investigated and compared to Rosemary. Methods: Methanolic extracts of dried powdered aerial parts of plants were prepared. Total phenolic compounds in extracts were determined spectrophotometrically using the Folin–Ciocalteu reagent. Antioxidant activity assessed by using 2, 2-diphenyl-1-picrylhydrazyl (DPPH) method. Results: The total phenolic content of plants extracts ranged from 38.27 to 58.45 mgGAEg-1 (Gallic acid equivalent/g dried weight), flavonoid content ranged from 25.5 to 182.23 mgQUEg-1 (mg Quercetin equivalent/g dried weight) and IC50 ranges from 55.52 to 489.9 μgml-1. Among the 7 different plants, Marrubium vulgare contained a higher level of phenolics and high antioxidant capacity compared to Rosemary, while Mentha spicata had the lowest content of phenolics. Conclusion: The antioxidant capacity determined by the 2, 2-diphenyl-1-picrylhydrazyl (DPPH) method was lowest for of Mentha spicata. These results clearly showed the antioxidant activity could be correlated with the phenolic components content in the extracts.}, Keywords = {Antioxidant activity, Flavonoids, Phenolic content, DPPH}, volume = {9}, Number = {34}, pages = {177-182}, publisher = {Institute of Medicinal Plants, ACECR}, url = {http://jmp.ir/article-1-305-en.html}, eprint = {http://jmp.ir/article-1-305-en.pdf}, journal = {Journal of Medicinal Plants}, issn = {2717-204X}, eissn = {2717-2058}, year = {2010} }