Journal of Medicinal Plants
فصلنامه گياهان دارویی
J. Med. Plants
Medical Sciences
http://jmp.ir
1
admin
2717-204X
2717-2058
10.61186/jmp
14
8888
13
en
jalali
1393
12
1
gregorian
2015
3
1
14
53
online
1
fulltext
en
A Systematic Review on Main Chemical Constituents of <i>Papaver bracteatum</i>
A Systematic Review on Main Chemical Constituents of <i>Papaver bracteatum</i>
فارماكوگنوزی و فارماسيوتيكس
Pharmacognosy & Pharmaceutics
پژوهشی
Research
<div dir="ltr" style="text-align: justify;">Papaver bracteatum Lindly (Papaveraceae) is an endemic species of Iran which has economic importance in drug industries. The main alkaloid of the plant is thebaine which is used as a precursor of the semi-synthetic and synthetic compounds including codeine and naloxone, respectively. This systematic review focuses on main component of Papaver bracteatum and methods used to determine thebaine. All studies which assessed the potential effect of the whole plant or its extract on clinical or preclinical studies were reviewed. In addition, methods for determination of the main components, especially thebaine, which have been published from 1948 to March 2013, were included. Exclusion criteria were agricultural studies that did not assess. This study has listed alkaloids identified in P. bracteatum which reported since 1948 to 2013. Also, the biological activities of main compounds of Papaver bracteatum including thebaine, isothebaine, (-)-nuciferine have been reviewed. As thebaine has many medicinal and industrial values, determination methods of thebaine in P. bracteatum were summarized. The methods have being used for determination of thebaine include chromatographic (HPLC, GC and TLC) and non chromatographic methods. HPLC methods seem to be the best method from the angle of time consuming, cost and data accuracy and precision.</div>
<div style="text-align: justify;">Papaver bracteatum Lindly (Papaveraceae) is an endemic species of Iran which has economic importance in drug industries. The main alkaloid of the plant is thebaine which is used as a precursor of the semi-synthetic and synthetic compounds including codeine and naloxone, respectively. This systematic review focuses on main component of Papaver bracteatum and methods used to determine thebaine. All studies which assessed the potential effect of the whole plant or its extract on clinical or preclinical studies were reviewed. In addition, methods for determination of the main components, especially thebaine, which have been published from 1948 to March 2013, were included. Exclusion criteria were agricultural studies that did not assess. This study has listed alkaloids identified in P. bracteatum which reported since 1948 to 2013. Also, the biological activities of main compounds of Papaver bracteatum including thebaine, isothebaine, (-)-nuciferine have been reviewed. As thebaine has many medicinal and industrial values, determination methods of thebaine in P. bracteatum were summarized. The methods have being used for determination of thebaine include chromatographic (HPLC, GC and TLC) and non chromatographic methods. HPLC methods seem to be the best method from the angle of time consuming, cost and data accuracy and precision.</div>
,Papaver bracteatum, Chemical constituents, Systematic review, Thebaine
Papaver bracteatum, Chemical constituents, Systematic review, Thebaine
6
14
http://jmp.ir/browse.php?a_code=A-10-123-7&slc_lang=en&sid=1
M
Soleymankhani
M
Soleymankhani
100319475328460041747
100319475328460041747
No
Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran
Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran
F
Khalighi-Sigaroodi
F
Khalighi-Sigaroodi
khalighi@imp.ac.ir
100319475328460041748
100319475328460041748
Yes
Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran
Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran
R
Hajiaghaee
R
Hajiaghaee
100319475328460041749
100319475328460041749
No
Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran
Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran
H
Naghdi Badi
H
Naghdi Badi
100319475328460041750
100319475328460041750
No
Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran
Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran
A
Mehrafarin
A
Mehrafarin
100319475328460041751
100319475328460041751
No
Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran
Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran
M
Ghorbani Nohooji
M
Ghorbani Nohooji
100319475328460041752
100319475328460041752
No
Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran
Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran