en فارماكوگنوزی و فارماسيوتيكس Pharmacognosy & Pharmaceutics پژوهشی Research <p style="text-align:justify"><b><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">Background:</span></span></span></b><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black"> Denture stomatitis is a common inflammatory condition in denture wearers primarily associated with <i>Candida</i> species. Conventional antifungal therapies are often limited by adverse side effects, high cost, and emerging drug resistance. <b>Objective:</b> To evaluate and compare the clinical efficacy of two herbal formulations - a ginger mouthwash and a combination ginger and yarrow mouthwash - against standard Nystatin suspension in patients with Type II denture stomatitis. <b>Methods:</b> In this double-blind, randomized clinical trial, 59 patients with Type II denture stomatitis were allocated to three intervention groups: ginger mouthwash, ginger&ndash;yarrow mouthwash, or Nystatin oral suspension. Palatal erythema was photographically evaluated on days 0, 7, 14, and 21. Surface area of erythema was quantified using ImageJ software. Inter- and intra-group differences were analyzed via one-way ANOVA and repeated-measures ANOVA, with statistical significance set at P < 0.05. <b>Results:</b> All three treatment regimens demonstrated a statistically significant reduction in palatal erythema over the 21-day period (P < 0.001). However, the Nystatin group achieved a significantly greater reduction in erythema area compared to both herbal mouthwash groups on days 7 and 14 (P < 0.05). By day 21, the difference between Nystatin and the herbal interventions was marginally significant (P = 0.054). <b>Conclusion:</b> While ginger and ginger&ndash;yarrow mouthwashes significantly reduce palatal inflammation, Nystatin suspension demonstrates superior speed and efficacy in the treatment of Type II denture stomatitis.</span></span></span></p> Achillea millefolium, Candida albicans, Denture Stomatitis, Ginger, Yarrow, Zingiber officinale 40 53 http://jmp.ir/browse.php?a_code=A-10-7124-1&slc_lang=en&sid=1 Seyed Mohammad Zaman Mousavikaani mousavikaani.mz@yahoo.com 100319475328460050188 0009-0001-9082-2934 No Dentist, D.D.S. Tehran, Iran Shirin Lavaf lavaf.sh@yahoo.com 100319475328460050189 100319475328460050189 No Department of Prosthodontics, Faculty of Dentistry TeMS.C., Islamic Azad University, Tehran, Iran Arezoo Alaee arezoo.alaee@yahoo.com 100319475328460050190 100319475328460050190 Yes The School of Medical Education and Learning Technologies, Shahid Beheshti University of Medical Sciences, Tehran, Iran