Journal of Medicinal Plants
فصلنامه گياهان دارویی
J. Med. Plants
Medical Sciences
http://jmp.ir
1
admin
2717-204X
2717-2058
10.61186/jmp
14
8888
13
en
jalali
1395
5
1
gregorian
2016
8
1
15
59
online
1
fulltext
en
Phytochemical and Antioxidant Activities of <i>Berberis integerrima</i> and <i>Berberis vulgaris</i> and Pharmacological Effects of the more Active Species on Alloxan-Induced Diabetic Rats
Phytochemical and Antioxidant Activities of <i>Berberis integerrima</i> and <i>Berberis vulgaris</i> and Pharmacological Effects of the more Active Species on Alloxan-Induced Diabetic Rats
فارماكولوژی و سم شناسی
Pharmacology & Toxicology
پژوهشی
Research
<p dir="ltr" style="margin-right: 9pt; text-align: justify;"><strong>Background:</strong> Medicinal plants with biologically active components such as antioxidant and antidiabetic are useful sources of novel therapeutics. In Iran, traditionally believed that the aqueous extract of berberry fruit (<em>Berberis integerima</em> F.) improved health, especially in people with diabetes.</p>
<p dir="ltr" style="margin-right: 9pt; text-align: justify;"><strong>Objective:</strong> In this study, in vitro phytochemical and antioxidant activities of <em>B. integerrima</em> and <em>B</em><em>. vulgaris</em> fruit aqueous extracts (BIFA and BVFA) were compared. Effects of more active species on fasting blood sugar (FBS), serum lipid, and malondialdehyde (MDA) were evaluated in alloxan-induced diabetic rats.</p>
<p dir="ltr" style="margin-right: 9pt; text-align: justify;"><strong>Methods: </strong>The phytochemical potential and antioxidant activity of these extracts were quantified in terms of total phenolic content and total reducing power, respectively. BIFA (500 mg/kg) and glibenclamide (2 mg/kg) were administered orally to alloxan-induced diabetic rats and FBS, body weight, lipid profile, and serum MDA were monitored at 0, 7, 14, and 21 days after induction of diabetes.</p>
<p dir="ltr" style="margin-right: 9pt; text-align: justify;"><strong>Results:</strong> BIFA showed the highest phenolic content (6.816 ± 0.132 mg/g of dry extract) and antioxidant activity (0.134 ± 0.022 EC<sub>50 </sub>mg/mL). LD<sub>50</sub> of BIFA was found to be ˃2500 mg/kg. FBS, lipid profile, and serum MDA have been significantly reduced in BIFA-treated rats after 21 days versus diabetic control and glibenclamide-treated rats. Extract has significantly decreased FBS levels of rats from 138.1 ± 1.68 to 82.00 ± 4.02 mg/dL. Furthermore, body weight has significantly improved in treated groups.</p>
<p dir="ltr" style="margin-right: 9pt; text-align: justify;"><strong>Conclusion:</strong> The results indicate <em>B. integerrima</em> with high phytochemical and antioxidant activities, has the potential of suppressed hyperglycemia, hyperlipidemia and lipid peroxidation.</p>
<p dir="ltr" style="margin-right: 9pt; text-align: justify;"><strong>Background:</strong> Medicinal plants with biologically active components such as antioxidant and antidiabetic are useful sources of novel therapeutics. In Iran, traditionally believed that the aqueous extract of berberry fruit (<em>Berberis integerima</em> F.) improved health, especially in people with diabetes.</p>
<p dir="ltr" style="margin-right: 9pt; text-align: justify;"><strong>Objective:</strong> In this study, in vitro phytochemical and antioxidant activities of <em>B. integerrima</em> and <em>B</em><em>. vulgaris</em> fruit aqueous extracts (BIFA and BVFA) were compared. Effects of more active species on fasting blood sugar (FBS), serum lipid, and malondialdehyde (MDA) were evaluated in alloxan-induced diabetic rats.</p>
<p dir="ltr" style="margin-right: 9pt; text-align: justify;"><strong>Methods: </strong>The phytochemical potential and antioxidant activity of these extracts were quantified in terms of total phenolic content and total reducing power, respectively. BIFA (500 mg/kg) and glibenclamide (2 mg/kg) were administered orally to alloxan-induced diabetic rats and FBS, body weight, lipid profile, and serum MDA were monitored at 0, 7, 14, and 21 days after induction of diabetes.</p>
<p dir="ltr" style="margin-right: 9pt; text-align: justify;"><strong>Results:</strong> BIFA showed the highest phenolic content (6.816 ± 0.132 mg/g of dry extract) and antioxidant activity (0.134 ± 0.022 EC<sub>50 </sub>mg/mL). LD<sub>50</sub> of BIFA was found to be ˃2500 mg/kg. FBS, lipid profile, and serum MDA have been significantly reduced in BIFA-treated rats after 21 days versus diabetic control and glibenclamide-treated rats. Extract has significantly decreased FBS levels of rats from 138.1 ± 1.68 to 82.00 ± 4.02 mg/dL. Furthermore, body weight has significantly improved in treated groups.</p>
<p dir="ltr" style="margin-right: 9pt; text-align: justify;"><strong>Conclusion:</strong> The results indicate <em>B. integerrima</em> with high phytochemical and antioxidant activities, has the potential of suppressed hyperglycemia, hyperlipidemia and lipid peroxidation.</p>
Antioxidant activity, Fasting Blood Sugar, Glibenclamide, Hyperglycemia, Phytochemical
Antioxidant activity, Fasting Blood Sugar, Glibenclamide, Hyperglycemia, Phytochemical
111
121
http://jmp.ir/browse.php?a_code=A-10-958-4&slc_lang=en&sid=1
M
Bayani
M
Bayani
100319475328460041495
100319475328460041495
No
Faculty of Veterinary Medicine, Semnan University, Semnan, Iran
Faculty of Veterinary Medicine, Semnan University, Semnan, Iran
M
Ahmadi-hamedani
M
Ahmadi-hamedani
m.ahmadi@profs.semnan.ac.ir
100319475328460041496
100319475328460041496
Yes
Department of Clinical Sciences, Faculty of Veterinary Medicine, Semnan University, Semnan, Iran
Department of Clinical Sciences, Faculty of Veterinary Medicine, Semnan University, Semnan, Iran
A
Jebelli Javan
A
Jebelli Javan
100319475328460041497
100319475328460041497
No
Department of Food Hygiene, Faculty of Veterinary Medicine, Semnan University, Semnan, Iran
Department of Food Hygiene, Faculty of Veterinary Medicine, Semnan University, Semnan, Iran