en <i>Malva sylvestris</i> L. Protects from Fluoride Nephrotoxicity in Rat فارماكولوژی و سم شناسی Pharmacology & Toxicology پژوهشی Research <p dir="ltr" style="margin-right: 7.1pt; text-align: justify;"><strong>Background:</strong><strong> </strong><em>Malva sylvestris </em>L. (<em>M. sylvestris</em>) has antioxidant property and is widely used in the traditional medicine to treat gastrointestinal, respiratory, skin and urological disorders.</p> <p dir="ltr" style="margin-right: 7.1pt; text-align: justify;"><strong>Objective:</strong><strong> </strong>In this study, the protective effect of <em>M. sylvestris</em> against sodium fluoride-induced nephrotoxicity in the rat was evaluated.</p> <p dir="ltr" style="margin-right: 7.1pt; text-align: justify;"><strong>Methods:</strong><strong> </strong>The <em>M. sylvestris</em> flower extract was prepared and injected intraperitoneally at the doses of 100, 200, 400 mg/kg/day to rat groups (10 in each group) for 1 week and subsequently 600 ppm sodium fluoride was added&nbsp; to the rats drinking water for 1 additional week. After these steps, the rat serum levels of urea, creatinine, reduced glutathione, catalase and malondialdehyde were determined. The histopathology of the rats&rsquo; kidney was also studied. In this study, vitamin C (10 mg/kg/day) was used as positive control.</p> <p dir="ltr" style="margin-right: 7.1pt; text-align: justify;"><strong>Results:</strong><strong> </strong>Sodium fluoride administration increased levels of BUN, creatinine, glutathione, catalase activity and decreased malondialdehyde levels indicating induction of nephrotoxicity in the rats. <em>M. sylvestris</em> extract pretreatment significantly decreased the BUN and creatinine levels (<em>P</em><0.05). Catalase activity and glutathione levels were significantly increased by <em>M. sylvestris</em> (<em>P</em><0.05). All three doses of the <em>M. sylvestris</em> decreased the malondialdehyde level, but it was significant only for the dose of 400 mg/kg/day (<em>P</em><0.05). The <em>Malva sylvestris</em> effects were comparable with those of vitamin C. Histopathological findings also showed protective effects of <em>M. sylvestris</em> against the renal damage induced by sodium fluoride.</p> <p dir="ltr" style="margin-right: 7.1pt; text-align: justify;"><strong>Conclusion:</strong><strong> </strong>The results suggest that <em>M. sylvestris</em> has protective effects against sodium fluoride-induced nephrotoxicity which maybe mediated by the antioxidant activity of the plant flavonoids.</p> <p dir="ltr" style="margin-right: 7.1pt; text-align: justify;"><strong>Background:</strong><strong> </strong><em>Malva sylvestris </em>L. (<em>M. sylvestris</em>) has antioxidant property and is widely used in the traditional medicine to treat gastrointestinal, respiratory, skin and urological disorders.</p> <p dir="ltr" style="margin-right: 7.1pt; text-align: justify;"><strong>Objective:</strong><strong> </strong>In this study, the protective effect of <em>M. sylvestris</em> against sodium fluoride-induced nephrotoxicity in the rat was evaluated.</p> <p dir="ltr" style="margin-right: 7.1pt; text-align: justify;"><strong>Methods:</strong><strong> </strong>The <em>M. sylvestris</em> flower extract was prepared and injected intraperitoneally at the doses of 100, 200, 400 mg/kg/day to rat groups (10 in each group) for 1 week and subsequently 600 ppm sodium fluoride was added&nbsp; to the rats drinking water for 1 additional week. After these steps, the rat serum levels of urea, creatinine, reduced glutathione, catalase and malondialdehyde were determined. The histopathology of the rats&rsquo; kidney was also studied. In this study, vitamin C (10 mg/kg/day) was used as positive control.</p> <p dir="ltr" style="margin-right: 7.1pt; text-align: justify;"><strong>Results:</strong><strong> </strong>Sodium fluoride administration increased levels of BUN, creatinine, glutathione, catalase activity and decreased malondialdehyde levels indicating induction of nephrotoxicity in the rats. <em>M. sylvestris</em> extract pretreatment significantly decreased the BUN and creatinine levels (<em>P</em><0.05). Catalase activity and glutathione levels were significantly increased by <em>M. sylvestris</em> (<em>P</em><0.05). All three doses of the <em>M. sylvestris</em> decreased the malondialdehyde level, but it was significant only for the dose of 400 mg/kg/day (<em>P</em><0.05). The <em>Malva sylvestris</em> effects were comparable with those of vitamin C. Histopathological findings also showed protective effects of <em>M. sylvestris</em> against the renal damage induced by sodium fluoride.</p> <p dir="ltr" style="margin-right: 7.1pt; text-align: justify;"><strong>Conclusion:</strong><strong> </strong>The results suggest that <em>M. sylvestris</em> has protective effects against sodium fluoride-induced nephrotoxicity which maybe mediated by the antioxidant activity of the plant flavonoids.</p> ,Malva sylvestris, Nephrotoxicity, Sodium fluoride, Rat Malva sylvestris, Nephrotoxicity, Sodium fluoride, Rat 21 32 http://jmp.ir/browse.php?a_code=A-10-71-24&slc_lang=en&sid=1 A Babai Zarch علی بابایی زارچ a_babaii@yahoo.com 100319475328460041379 100319475328460041379 No Department of Pharmacology, Faculty of Pharmacy, Yazd Shahid Sadoughi University of Medical Sciences, Yazd, Iran Department of Pharmacology, Faculty of Pharmacy, Yazd Shahid Sadoughi University of Medical Sciences, Yazd, Iran H Fallah Huseini حسن فلاح حسینی huseini_fallah@yahoo.com 100319475328460041380 100319475328460041380 No Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran S Kianbakht سعید کیان بخت skianbakht@yahoo.com 100319475328460041381 100319475328460041381 Yes Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran P Changaei پیام چنگایی pchangaei@gmail.com 100319475328460041382 100319475328460041382 No Department of Pharmacology, Faculty of Pharmacy, Yazd Shahid Sadoughi University of Medical Sciences, Yazd, Iran Department of Pharmacology, Faculty of Pharmacy, Yazd Shahid Sadoughi University of Medical Sciences, Yazd, Iran A Mirjalili اقدس میرجلیلی aghdasmirgalili@yahoo.com 100319475328460041383 100319475328460041383 No Department of Pharmacology, Faculty of Pharmacy, Yazd Shahid Sadoughi University of Medical Sciences, Yazd, Iran Department of Pharmacology, Faculty of Pharmacy, Yazd Shahid Sadoughi University of Medical Sciences, Yazd, Iran J Salehi جلیل صالحی Salehiran90@gmail.com 100319475328460041384 100319475328460041384 No Department of Pharmacology, Faculty of Pharmacy, Yazd Shahid Sadoughi University of Medical Sciences, Yazd, Iran Department of Pharmacology, Faculty of Pharmacy, Yazd Shahid Sadoughi University of Medical Sciences, Yazd, Iran