Journal of Medicinal Plants
فصلنامه گياهان دارویی
J. Med. Plants
Medical Sciences
http://jmp.ir
1
admin
2717-204X
2717-2058
10.61186/jmp
14
8888
13
en
jalali
1395
11
1
gregorian
2017
2
1
16
61
online
1
fulltext
en
<i>Malva sylvestris</i> L. Protects from Fluoride Nephrotoxicity in Rat
<i>Malva sylvestris</i> L. Protects from Fluoride Nephrotoxicity in Rat
فارماكولوژی و سم شناسی
Pharmacology & Toxicology
پژوهشی
Research
<p dir="ltr" style="margin-right: 7.1pt; text-align: justify;"><strong>Background:</strong><strong> </strong><em>Malva sylvestris </em>L. (<em>M. sylvestris</em>) has antioxidant property and is widely used in the traditional medicine to treat gastrointestinal, respiratory, skin and urological disorders.</p>
<p dir="ltr" style="margin-right: 7.1pt; text-align: justify;"><strong>Objective:</strong><strong> </strong>In this study, the protective effect of <em>M. sylvestris</em> against sodium fluoride-induced nephrotoxicity in the rat was evaluated.</p>
<p dir="ltr" style="margin-right: 7.1pt; text-align: justify;"><strong>Methods:</strong><strong> </strong>The <em>M. sylvestris</em> flower extract was prepared and injected intraperitoneally at the doses of 100, 200, 400 mg/kg/day to rat groups (10 in each group) for 1 week and subsequently 600 ppm sodium fluoride was added to the rats drinking water for 1 additional week. After these steps, the rat serum levels of urea, creatinine, reduced glutathione, catalase and malondialdehyde were determined. The histopathology of the rats’ kidney was also studied. In this study, vitamin C (10 mg/kg/day) was used as positive control.</p>
<p dir="ltr" style="margin-right: 7.1pt; text-align: justify;"><strong>Results:</strong><strong> </strong>Sodium fluoride administration increased levels of BUN, creatinine, glutathione, catalase activity and decreased malondialdehyde levels indicating induction of nephrotoxicity in the rats. <em>M. sylvestris</em> extract pretreatment significantly decreased the BUN and creatinine levels (<em>P</em><0.05). Catalase activity and glutathione levels were significantly increased by <em>M. sylvestris</em> (<em>P</em><0.05). All three doses of the <em>M. sylvestris</em> decreased the malondialdehyde level, but it was significant only for the dose of 400 mg/kg/day (<em>P</em><0.05). The <em>Malva sylvestris</em> effects were comparable with those of vitamin C. Histopathological findings also showed protective effects of <em>M. sylvestris</em> against the renal damage induced by sodium fluoride.</p>
<p dir="ltr" style="margin-right: 7.1pt; text-align: justify;"><strong>Conclusion:</strong><strong> </strong>The results suggest that <em>M. sylvestris</em> has protective effects against sodium fluoride-induced nephrotoxicity which maybe mediated by the antioxidant activity of the plant flavonoids.</p>
<p dir="ltr" style="margin-right: 7.1pt; text-align: justify;"><strong>Background:</strong><strong> </strong><em>Malva sylvestris </em>L. (<em>M. sylvestris</em>) has antioxidant property and is widely used in the traditional medicine to treat gastrointestinal, respiratory, skin and urological disorders.</p>
<p dir="ltr" style="margin-right: 7.1pt; text-align: justify;"><strong>Objective:</strong><strong> </strong>In this study, the protective effect of <em>M. sylvestris</em> against sodium fluoride-induced nephrotoxicity in the rat was evaluated.</p>
<p dir="ltr" style="margin-right: 7.1pt; text-align: justify;"><strong>Methods:</strong><strong> </strong>The <em>M. sylvestris</em> flower extract was prepared and injected intraperitoneally at the doses of 100, 200, 400 mg/kg/day to rat groups (10 in each group) for 1 week and subsequently 600 ppm sodium fluoride was added to the rats drinking water for 1 additional week. After these steps, the rat serum levels of urea, creatinine, reduced glutathione, catalase and malondialdehyde were determined. The histopathology of the rats’ kidney was also studied. In this study, vitamin C (10 mg/kg/day) was used as positive control.</p>
<p dir="ltr" style="margin-right: 7.1pt; text-align: justify;"><strong>Results:</strong><strong> </strong>Sodium fluoride administration increased levels of BUN, creatinine, glutathione, catalase activity and decreased malondialdehyde levels indicating induction of nephrotoxicity in the rats. <em>M. sylvestris</em> extract pretreatment significantly decreased the BUN and creatinine levels (<em>P</em><0.05). Catalase activity and glutathione levels were significantly increased by <em>M. sylvestris</em> (<em>P</em><0.05). All three doses of the <em>M. sylvestris</em> decreased the malondialdehyde level, but it was significant only for the dose of 400 mg/kg/day (<em>P</em><0.05). The <em>Malva sylvestris</em> effects were comparable with those of vitamin C. Histopathological findings also showed protective effects of <em>M. sylvestris</em> against the renal damage induced by sodium fluoride.</p>
<p dir="ltr" style="margin-right: 7.1pt; text-align: justify;"><strong>Conclusion:</strong><strong> </strong>The results suggest that <em>M. sylvestris</em> has protective effects against sodium fluoride-induced nephrotoxicity which maybe mediated by the antioxidant activity of the plant flavonoids.</p>
,Malva sylvestris, Nephrotoxicity, Sodium fluoride, Rat
Malva sylvestris, Nephrotoxicity, Sodium fluoride, Rat
21
32
http://jmp.ir/browse.php?a_code=A-10-71-24&slc_lang=en&sid=1
A
Babai Zarch
علی
بابایی زارچ
a_babaii@yahoo.com
100319475328460041379
100319475328460041379
No
Department of Pharmacology, Faculty of Pharmacy, Yazd Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Department of Pharmacology, Faculty of Pharmacy, Yazd Shahid Sadoughi University of Medical Sciences, Yazd, Iran
H
Fallah Huseini
حسن
فلاح حسینی
huseini_fallah@yahoo.com
100319475328460041380
100319475328460041380
No
Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran
Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran
S
Kianbakht
سعید
کیان بخت
skianbakht@yahoo.com
100319475328460041381
100319475328460041381
Yes
Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran
Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran
P
Changaei
پیام
چنگایی
pchangaei@gmail.com
100319475328460041382
100319475328460041382
No
Department of Pharmacology, Faculty of Pharmacy, Yazd Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Department of Pharmacology, Faculty of Pharmacy, Yazd Shahid Sadoughi University of Medical Sciences, Yazd, Iran
A
Mirjalili
اقدس
میرجلیلی
aghdasmirgalili@yahoo.com
100319475328460041383
100319475328460041383
No
Department of Pharmacology, Faculty of Pharmacy, Yazd Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Department of Pharmacology, Faculty of Pharmacy, Yazd Shahid Sadoughi University of Medical Sciences, Yazd, Iran
J
Salehi
جلیل
صالحی
Salehiran90@gmail.com
100319475328460041384
100319475328460041384
No
Department of Pharmacology, Faculty of Pharmacy, Yazd Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Department of Pharmacology, Faculty of Pharmacy, Yazd Shahid Sadoughi University of Medical Sciences, Yazd, Iran