Journal of Medicinal Plants
فصلنامه گياهان دارویی
J. Med. Plants
Medical Sciences
http://jmp.ir
1
admin
2717-204X
2717-2058
10.61186/jmp
14
8888
13
en
jalali
1394
11
1
gregorian
2016
2
1
15
57
online
1
fulltext
en
Optimal fabrication of nano menthol/PEG particles by electrospraying
Optimal fabrication of nano menthol/PEG particles by electrospraying
فارماكوگنوزی و فارماسيوتيكس
Pharmacognosy & Pharmaceutics
پژوهشی
Research
<p dir="ltr" style="text-align: justify;"><strong>Background:</strong> L-menthol [(1R,3R,4S)-(-)-menthol] is a flavoring that is the main component of mint herb essential oils, especially of the <em>Menthapiperita</em> and <em>Menthaarvensis</em>species. Menthol is used commercially in a variety of products for its antioxidant, antibacterial, anti-inflammatory, and cooling characteristics. Both natural and synthetic menthol is found in powder crystalline form. Its low solubility in aqueous systems makes precise formulation necessary in the final products.Of the methods available for fabrication of nanoparticles for use in pharmaceuticals, electrospraying is easy and requires only one step.</p>
<p dir="ltr" style="text-align: justify;"><strong>Objective:</strong> Electrospraying was used to fabricate menthol/PEG micro/nanoparticles. The experiments used menthol concentrations of 10%, 15% and 20% (wt) and PEG concentrations of 5%, 10% and 15% (wt).</p>
<p dir="ltr" style="text-align: justify;"><strong>Methods</strong>: The effect of menthol and PEG concentration on the morphology of the fabricated particles was investigated using scanning electron microscopy (SEM). Response surface methodology (RSM) was used to determine the best levels for each parameter under optimal conditions.</p>
<p dir="ltr" style="text-align: justify;"><strong>Results:</strong> SEM results revealed that an increase in PEG and menthol concentrations in solution, increased the particle diameters. RSM showed that particle diameter should be calculated as the square root of a function of the first order and cubic forms of menthol and PEG. Optimization results show that the optimal menthol concentration is 10.7% (wt) and PEG concentration is 7.31% (wt). The optimal modeled particle diameter of 1219 nm approached the real test particle diameters (1136 nm). The results indicate that the modeled conditions were appropriate for menthol/PEG electrospray particles.</p>
<p dir="ltr" style="text-align: justify;"><strong>Conclusion:</strong> The results showed that the maximum PEG concentration effects particle diameter because of its polymeric structure. At high menthol concentrations, the percentage of menthol in a droplet was greater than the PEG concentration and some menthol sublimated during drop formation. At low menthol concentrations, PEG covered the menthol and prevented sublimation, decreasing the effect of menthol concentration.</p>
<p><strong>Background:</strong> L-menthol [(1R,3R,4S)-(-)-menthol] is a flavoring that is the main component of mint herb essential oils, especially of the <em>Menthapiperita</em> and <em>Menthaarvensis</em>species. Menthol is used commercially in a variety of products for its antioxidant, antibacterial, anti-inflammatory, and cooling characteristics. Both natural and synthetic menthol is found in powder crystalline form. Its low solubility in aqueous systems makes precise formulation necessary in the final products.Of the methods available for fabrication of nanoparticles for use in pharmaceuticals, electrospraying is easy and requires only one step.</p>
<p><strong>Objective:</strong> Electrospraying was used to fabricate menthol/PEG micro/nanoparticles. The experiments used menthol concentrations of 10%, 15% and 20% (wt) and PEG concentrations of 5%, 10% and 15% (wt).</p>
<p><strong>Methods</strong>: The effect of menthol and PEG concentration on the morphology of the fabricated particles was investigated using scanning electron microscopy (SEM). Response surface methodology (RSM) was used to determine the best levels for each parameter under optimal conditions.</p>
<p><strong>Results:</strong> SEM results revealed that an increase in PEG and menthol concentrations in solution, increased the particle diameters. RSM showed that particle diameter should be calculated as the square root of a function of the first order and cubic forms of menthol and PEG. Optimization results show that the optimal menthol concentration is 10.7% (wt) and PEG concentration is 7.31% (wt). The optimal modeled particle diameter of 1219 nm approached the real test particle diameters (1136 nm). The results indicate that the modeled conditions were appropriate for menthol/PEG electrospray particles.</p>
<p><strong>Conclusion:</strong> The results showed that the maximum PEG concentration effects particle diameter because of its polymeric structure. At high menthol concentrations, the percentage of menthol in a droplet was greater than the PEG concentration and some menthol sublimated during drop formation. At low menthol concentrations, PEG covered the menthol and prevented sublimation, decreasing the effect of menthol concentration.</p>
Menthol, Electrospray, Micro/nanoparticles, Optimization
Menthol, Electrospray, Micro/nanoparticles, Optimization
82
88
http://jmp.ir/browse.php?a_code=A-10-218-4&slc_lang=en&sid=1
M
Aali-Kordkolaei
M
Aali-Kordkolaei
maral_akk@gmail.com
100319475328460041620
100319475328460041620
No
School of Chemical Engineering, College of Engineering, University of Tehran, Tehran, Iran
University of Tehran
R
Zarghami
R
Zarghami
R_zarghami@ut.ac.ir
100319475328460041621
100319475328460041621
No
School of Chemical Engineering, College of Engineering, University of Tehran, Tehran, Iran
School of Chemical Engineering, College of Engineering, University of Tehran, Tehran, Iran
S
Mirzakhanlouei
S
Mirzakhanlouei
khanluei.sassan@gmail.com
100319475328460041622
100319475328460041622
No
Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran
Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran
Sh
Rezazadeh
Sh
Rezazadeh
shrezazadeh@yahoo.com
100319475328460041623
100319475328460041623
No
Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran
Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran
R
Hajiaghaee
R
Hajiaghaee
rhajiaghaee@yahoo.com
100319475328460041624
100319475328460041624
No
Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran
Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran
R
Ghaffarzadegan
R
Ghaffarzadegan
Reza.ghafary@yahoo.com
100319475328460041625
100319475328460041625
Yes
Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran
Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran