TY - JOUR T1 - Cytotoxic Effects of Essential Oils and Extracts of some Mentha species on Vero, Hela and Hep2 Cell Lines TT - Cytotoxic Effects of Essential Oils and Extracts of some Mentha species on Vero, Hela and Hep2 Cell Lines JF - jmpir JO - jmpir VL - 9 IS - 35 UR - http://jmp.ir/article-1-270-fa.html Y1 - 2010 SP - 88 EP - 92 KW - < KW - i> KW - Mentha< KW - /i> KW - Cytotoxic effects KW - MTT KW - Vero KW - Hela KW - Hep2 cell line N2 - Background: Mentha species are widely used in traditional medicine mostly as anti-flatulence. Nowadays, their usage as flavor and preservative in food, cosmetic and pharmaceutical industries has been developed. Moreover, cytotoxic effects of some Mentha species have been reported. Objective: In this study, cytotoxic properties of Mentha piperita, M. spicata, M. aquatica, M. crispa, M. pulegium and M. longifolia have been investigated. Methods: Different concentrations of essential oils and total extracts of six Mentha species were tested by MTT assay against Vero, Hep2 and Hela cell lines. Results: The results showed that all samples were toxic against Vero, Hela and Hep2 cell lines (IC50 28.1-166.2 µg/ml). Conclusion: All examined Mentha species extracts and essential oils have cytotoxic effects but some of them could be considered as potent toxic agents. M3 ER -